KEGG   ENZYME: 2.1.1.239Help
Entry
EC 2.1.1.239                Enzyme                                 

Name
L-olivosyl-oleandolide 3-O-methyltransferase;
OleY
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + L-olivosyl-oleandolide = S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide [RN:R06456]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-olivosyl-oleandolide [CPD:C11991]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
L-oleandrosyl-oleandolide [CPD:C11992]
Comment
The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus. It can also act on other monoglycosylated macrolactones, including L-rhamnosyl-erythronolide B and L-mycarosyl-erythronolide B.
History
EC 2.1.1.239 created 2012
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01130  Biosynthesis of antibiotics
Orthology
K13320  L-olivosyl-oleandolide 3-O-methyltransferase
Reference
1  [PMID:11514520]
  Authors
Rodriguez L, Rodriguez D, Olano C, Brana AF, Mendez C, Salas JA.
  Title
Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus.
  Journal
J Bacteriol 183:5358-63 (2001)
DOI:10.1128/JB.183.18.5358-5363.2001
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.239
IUBMB Enzyme Nomenclature: 2.1.1.239
ExPASy - ENZYME nomenclature database: 2.1.1.239
BRENDA, the Enzyme Database: 2.1.1.239

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