KEGG   ENZYME: 2.1.1.243Help
Entry
EC 2.1.1.243                Enzyme                                 

Name
2-ketoarginine methyltransferase;
mrsA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5-carbamimidamido-2-oxopentanoate S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate [RN:R09939]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5-guanidino-2-oxopentanoate [CPD:C03771]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-guanidino-3-methyl-2-oxopentanoate [CPD:C20234]
Comment
The enzyme is involved in production of the rare amino acid 3-methylarginine, which is used by the epiphytic bacterium Pseudomonas syringae pv. syringae as an antibiotic against the related pathogenic species Pseudomonas syringae pv. glycinea.
History
EC 2.1.1.243 created 2012
Orthology
K16215  2-ketoarginine methyltransferase
Genes
PSB: Psyr_0118
BMAE: DM78_1594
BPS: BPSL1723
BPM: BURPS1710b_2150
BPL: BURPS1106A_2014
BPD: BURPS668_1994
BPR: GBP346_A2040
BPSE: BDL_243
BPSM: BBQ_1583
BPSU: BBN_1708
BPSD: BBX_2180
BPK: BBK_3207
BPSH: DR55_2815
BPSA: BBU_418
BPSO: X996_2438
BUT: X994_885
BOK: DM82_5333
BOC: BG90_5276
BGO: BM43_2864
AAV: Aave_3704
SBH: SBI_00619
STRM: M444_32675
 » show all
Taxonomy
Reference
1  [PMID:20190091]
  Authors
Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D
  Title
Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93.
  Journal
Appl Environ Microbiol 76:2500-8 (2010)
DOI:10.1128/AEM.00666-09
  Sequence
[psb:Psyr_0118]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.243
IUBMB Enzyme Nomenclature: 2.1.1.243
ExPASy - ENZYME nomenclature database: 2.1.1.243
BRENDA, the Enzyme Database: 2.1.1.243

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