KEGG   ENZYME: 2.1.1.245Help
Entry
EC 2.1.1.245                Enzyme                                 

Name
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase;
cdhD (gene name);
cdhE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin [RN:R10385]
Reaction(KEGG)
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrosarcinapterin [CPD:C18802]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrosarcinapterin [CPD:C18799]
Comment
Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin) and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate.
History
EC 2.1.1.245 created 2012
Orthology
K00194  acetyl-CoA decarbonylase/synthase complex subunit delta
K00197  acetyl-CoA decarbonylase/synthase complex subunit gamma
Genes
GUR: Gura_0480
DAK: DaAHT2_0824
DSF: UWK_03161
DOL: Dole_3183
DML: Dmul_30830(cdhD) Dmul_30860(cdhE)
DAL: Dalk_0679 Dalk_0682
DAT: HRM2_16650(cdhE) HRM2_16690(cdhD)
DTO: TOL2_C11800(cdhE) TOL2_C11830(cdhD)
SAT: SYN_00351
DAO: Desac_1965 Desac_1968
CACE: CACET_c10290(acsD) CACET_c10300(acsC)
PDC: CDIF630_00841(acsD) CDIF630_00842(acsC)
PTH: PTH_1001(CdhE) PTH_1003(CdhD)
DED: DHBDCA_p226(acsC) DHBDCA_p227(acsD)
DEC: DCF50_p286(acsC) DCF50_p287(acsD)
AWO: Awo_c10710(acsD) Awo_c10720(acsC)
TKI: TKV_c19840(acsC) TKV_c19850(acsD)
CHY: CHY_1223(acsC) CHY_1226(acsD)
TAE: TepiRe1_0610(acsD) TepiRe1_0611(acsC)
TPZ: Tph_c15140(acsD) Tph_c15160(acsC)
DET: DET0665(acsC-1) DET0667(acsD-1) DET0699(acsC-2) DET0701(acsD-2)
DEH: cbdbA651(acsC) cbdbA654(acsD)
DEV: DhcVS_603(cdhE) DhcVS_605(cdhD)
DMC: btf_621(acsC) btf_623(acsD)
DMD: dcmb_667(acsC) dcmb_669(acsD)
DMG: GY50_0590(cdhE) GY50_0592(cdhD)
DUC: UCH007_05830(acsC) UCH007_05850(acsD)
DFO: Dform_00888(cdhE|acsC) Dform_00913(cdhD|acsD) Dform_00915(cdhE|acsC)
KST: KSMBR1_1320(acsD) KSMBR1_1323(acsC_1)
CTHI: THC_1763
MMP: MMP0980(cdh) MMP0981(cdhD)
MMG: MTBMA_c02910(cdhD) MTBMA_c02920(cdhE)
MWO: MWSIV6_0253(cdhD) MWSIV6_0254(cdhE)
METE: tca_01659(acsD) tca_01660(acsC_2)
METH: MBMB1_1560(cdhE) MBMB1_1561(cdhD)
MFC: BRM9_0796(cdhE) BRM9_0797(cdhD)
MFI: DSM1535_0758(cdhE) DSM1535_0759(cdhD)
MCUB: MCBB_1816(cdhE) MCBB_1817(cdhD)
MKA: MK0722(cdhD) MK0723(cdhE)
MEAR: Mpt1_c14390(cdhE)
MAC: MA_1011(cdhE) MA_1012(cdhD) MA_3864(cdhD) MA_3865(cdhE)
MCJ: MCON_1325(cdhE) MCON_1326(cdhD)
MBG: BN140_2373(acsC) BN140_2374(acsD)
RCI: LRC461(cdhD) LRC463(cdhE)
BARC: AOA65_0450(cdhE1) AOA65_0451(cdhD)
BARB: AOA66_1431(cdhD) AOA66_1432(cdhE1)
LOKI: Lokiarch_02230(cdhD_1) Lokiarch_02240(cdhD_2) Lokiarch_43060(cdhD_3) Lokiarch_43070(cdhD_4)
 » show all
Taxonomy
Reference
1  [PMID:8550451]
  Authors
Maupin-Furlow J, Ferry JG
  Title
Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina  thermophila.
  Journal
J Bacteriol 178:340-6 (1996)
DOI:10.1128/JB.178.2.340-346.1996
  Sequence
Reference
2  [PMID:8626532]
  Authors
Grahame DA, DeMoll E.
  Title
Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri.
  Journal
J Biol Chem 271:8352-8 (1996)
DOI:10.1074/jbc.271.14.8352
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.245
IUBMB Enzyme Nomenclature: 2.1.1.245
ExPASy - ENZYME nomenclature database: 2.1.1.245
BRENDA, the Enzyme Database: 2.1.1.245

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