KEGG   ENZYME: 2.1.1.250Help
Entry
EC 2.1.1.250                Enzyme                                 

Name
trimethylamine---corrinoid protein Co-methyltransferase;
mttB (gene name);
trimethylamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] = a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine [RN:R10016]
Reaction(KEGG)
R10016;
(other) R09124
Show
Substrate
trimethylamine [CPD:C00565];
[Co(I) trimethylamine-specific corrinoid protein]
Product
[methyl-Co(III) trimethylamine-specific corrinoid protein];
dimethylamine [CPD:C00543]
Comment
The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine [2]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
History
EC 2.1.1.250 created 2012
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K14083  trimethylamine---corrinoid protein Co-methyltransferase
Genes
GAI: IMCC3135_27710
TSN: W908_00365 W908_00465 W908_00520 W908_00960 W908_08075
AZA: AZKH_p0144
DAK: DaAHT2_2485 DaAHT2_2487 DaAHT2_2574
DOL: Dole_1111
DML: Dmul_15240(mttB1) Dmul_16770(mttB2)
DAL: Dalk_4373
DAT: HRM2_00490(mttB1) HRM2_01250(mttB2) HRM2_07480(mttB3) HRM2_09120(mttB4) HRM2_15910(mttB5) HRM2_15930(mttB6) HRM2_44090(mttB7) HRM2_44130(mttB8) HRM2_44190(mttB9) HRM2_44210(mttB10) HRM2_45990(mttB711)
DTO: TOL2_C12300(mttB) TOL2_C12310
MLO: mll1230 mll1516 mll1654 mll5409 mlr1212 mlr8280
SFD: USDA257_c05310(mttB1) USDA257_c42530(mttB2) USDA257_c45720(mttB3)
RSP: RSP_2813(mttB) RSP_4008
PAMN: pAMV3p0238
DSH: Dshi_1586(mttb) Dshi_2817
PGA: PGA1_c08570 PGA1_c14630(mttB1) PGA1_c16500(mttB2) PGA1_c25550(mttB3)
PGL: PGA2_c08310 PGA2_c14540(mttB1) PGA2_c16330(mttB2)
OAT: OAN307_c14400(mttB1) OAN307_c22520(mttB3) OAN307_c25200(mttB2)
RSU: NHU_02107
RHC: RGUI_0134
CACE: CACET_c34470(mttB)
AWO: Awo_c05430(mttB3) Awo_c05440(mttB4) Awo_c05470(mttB5) Awo_c07540(mttB10) Awo_c27930(mttB21) Awo_c27940(mttB22)
MARC: AR505_0772
MAC: MA_0528(mttB) MA_0932(mttB)
MBAR: MSBR2_1920
MBAK: MSBR3_1951
MMA: MM_1688(mttB) MM_1689(mttB) MM_2048(mttB) MM_2049(mttB)
MHOR: MSHOH_3689
MBU: Mbur_2308 Mbur_2313(mttB)
MMET: MCMEM_1860
MPY: Mpsy_1687(mttB) Mpsy_1688(mttB2)
HHSR: HSR6_1744 HSR6_1804(mttB)
TPE: Tpen_1467
LOKI: Lokiarch_24540(mttB)
 » show all
Taxonomy
Reference
1  [PMID:9006042]
  Authors
Ferguson DJ Jr, Krzycki JA
  Title
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.
  Journal
J Bacteriol 179:846-52 (1997)
DOI:10.1128/JB.179.3.846-852.1997
  Sequence
Reference
2  [PMID:15450490]
  Authors
Krzycki JA
  Title
Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
  Journal
Curr Opin Chem Biol 8:484-91 (2004)
DOI:10.1016/j.cbpa.2004.08.012
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.250
IUBMB Enzyme Nomenclature: 2.1.1.250
ExPASy - ENZYME nomenclature database: 2.1.1.250
BRENDA, the Enzyme Database: 2.1.1.250

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