KEGG   ENZYME: 2.1.1.255Help
Entry
EC 2.1.1.255                Enzyme                                 

Name
geranyl diphosphate 2-C-methyltransferase;
SCO7701;
GPP methyltransferase;
GPPMT;
2-methyl-GPP synthase;
MGPPS;
geranyl pyrophosphate methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate [RN:R09940]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
geranyl diphosphate [CPD:C00341]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-methylgeranyl diphosphate [CPD:C20235]
Comment
This enzyme, along with EC 4.2.3.118, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour.
History
EC 2.1.1.255 created 2012
Orthology
K16217  geranyl diphosphate 2-C-methyltransferase
Genes
MMI: MMAR_1565
MMAE: MMARE11_14780
MLI: MULP_01696
NBR: O3I_013630 O3I_015975
NNO: NONO_c25600
NSR: NS506_02329 NS506_05723
NTP: CRH09_13805
RFA: A3L23_04940 A3L23_04941
SCO: SCO7701(SCBAC12C8.02)
SMA: SAVERM_983(gmt)
SGR: SGR_1268
SCB: SCAB_5031
SFA: Sfla_5666
SBH: SBI_08956
SVE: SVEN_7112
STRP: F750_0932
SALU: DC74_7953
SALL: SAZ_41060
STRM: M444_04655
SMAL: SMALA_1170
SLAU: SLA_6492
SALF: SMD44_08712(gppmt)
SALJ: SMD11_0059(gppmt) SMD11_0840(gppmt)
SFK: KY5_0685
KSK: KSE_70220
NDA: Ndas_2619
NAL: B005_4058(gdpmt)
SEN: SACE_3721
AMD: AMED_3241
AMN: RAM_16485
AMM: AMES_3206
AMZ: B737_3206
AOI: AORI_4063
SESP: BN6_41360
KAL: KALB_4604
ASE: ACPL_2024
ACTS: ACWT_1902
CAI: Caci_4613
SNA: Snas_1990
 » show all
Taxonomy
Reference
1  [PMID:18563898]
  Authors
Wang CM, Cane DE
  Title
Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.
  Journal
J Am Chem Soc 130:8908-9 (2008)
DOI:10.1021/ja803639g
  Sequence
[sco:SCO7701]
Reference
2  [PMID:21393856]
  Authors
Ariyawutthiphan O, Ose T, Tsuda M, Gao Y, Yao M, Minami A, Oikawa H, Tanaka I
  Title
Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 67:417-20 (2011)
DOI:10.1107/S1744309110051523
Reference
3  [PMID:18492804]
  Authors
Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H
  Title
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
  Journal
Proc Natl Acad Sci U S A 105:7422-7 (2008)
DOI:10.1073/pnas.0802312105
  Sequence
[sen:SACE_3721] [ag:BAI77524]
Reference
4  [PMID:21174459]
  Authors
Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT
  Title
Biosynthesis of 2-methylisoborneol in cyanobacteria.
  Journal
Environ Sci Technol 45:992-8 (2011)
DOI:10.1021/es102992p
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.255
IUBMB Enzyme Nomenclature: 2.1.1.255
ExPASy - ENZYME nomenclature database: 2.1.1.255
BRENDA, the Enzyme Database: 2.1.1.255

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