KEGG   ENZYME: 2.1.1.256Help
Entry
EC 2.1.1.256                Enzyme                                 

Name
tRNA (guanine6-N2)-methyltransferase;
methyltransferase Trm14;
m2G6 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanine6 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanine6 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N2-methylguanine6 in tRNA
Comment
The enzyme specifically methylates guanine6 at N2 in tRNA.
History
EC 2.1.1.256 created 2012
Orthology
K16318  tRNA (guanine6-N2)-methyltransferase
Genes
HAO: PCC7418_2648
STA: STHERM_c21710
FLI: Fleli_3175
TTK: TST_0098
MJA: MJ_0438
MFE: Mefer_0982
MVU: Metvu_0180
MFS: MFS40622_1705
MIF: Metin_1016
MJH: JH146_1351
MFV: Mfer_0655
MKA: MK0969
AFU: AF_2178
FPL: Ferp_1541
GAH: GAH_00519
ABI: Aboo_0151
PHO: PH0644(PH0644)
PAB: PAB0923
PFU: PF1002
PFI: PFC_04240
PYN: PNA2_1264
PYS: Py04_1110
TKO: TK1863
TON: TON_1671
TGA: TGAM_0202
TSI: TSIB_1962
THE: GQS_06995
THA: TAM4_1322
THM: CL1_1031
TLT: OCC_10594
THS: TES1_1851
TNU: BD01_1790
TEU: TEU_02565
PPAC: PAP_00370
NPH: NP_0864A(trm14)
NMO: Nmlp_3856(trm14)
APE: APE_0557
ACJ: ACAM_0426
SMR: Smar_0628
IHO: Igni_0818
IIS: EYM_05845
IAG: Igag_1278
HBU: Hbut_1654
PAI: PAE3215
PIS: Pisl_0408
PCL: Pcal_1100
PAS: Pars_1254
PYR: P186_1525
POG: Pogu_0968
TNE: Tneu_1720
TUZ: TUZN_0760
TTN: TTX_1069
VDI: Vdis_0007
VMO: VMUT_0894
NCV: NCAV_1216
NEQ: NEQ522
KCR: Kcr_0662
BARC: AOA65_1404
 » show all
Taxonomy
Reference
1  [PMID:21693558]
  Authors
Menezes S, Gaston KW, Krivos KL, Apolinario EE, Reich NO, Sowers KR, Limbach PA, Perona JJ
  Title
Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14.
  Journal
Nucleic Acids Res 39:7641-55 (2011)
DOI:10.1093/nar/gkr475
  Sequence
[mja:MJ_0438]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.256
IUBMB Enzyme Nomenclature: 2.1.1.256
ExPASy - ENZYME nomenclature database: 2.1.1.256
BRENDA, the Enzyme Database: 2.1.1.256

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