KEGG   ENZYME: 2.1.1.258Help
Entry
EC 2.1.1.258                Enzyme                                 

Name
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase;
acsE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate [RN:R02289]
Reaction(KEGG)
R02289;
(other) R10243
Show
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrofolate [CPD:C00101]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrofolate [CPD:C00440]
Comment
Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin) and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.
History
EC 2.1.1.258 created 2012
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K15023  5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase
Genes
DAK: DaAHT2_1991
DSF: UWK_01140
DOL: Dole_3182
DML: Dmul_30880(metH) Dmul_32250
DAL: Dalk_0683
DAT: HRM2_16640(metH3)
DTO: TOL2_C05310 TOL2_C11790(metH)
DAO: Desac_1969
DTI: Desti_0229
SFU: Sfum_2563
DBR: Deba_0238
CLJ: CLJU_c37560(meTr)
CSQ: CSCA_4550
CACE: CACET_c10310(acsE)
AMT: Amet_2027
RUM: CK1_12640
ROB: CK5_28650
PDC: CDIF630_00843(acsE)
DSY: DSY1647
DHD: Dhaf_2792
DAE: Dtox_1276
PTH: PTH_1004(MetH)
DAU: Daud_0876
ELM: ELI_3604
AWO: Awo_c10730(acsE)
CTHM: CFE_1661
TKI: TKV_c19830(acsE)
CHY: CHY_1227(acsE)
MTA: Moth_1197
ADG: Adeg_0341
TPZ: Tph_c15130(acsE)
TOC: Toce_0812
KST: KSMBR1_1319(acsE)
PBU: L21SP3_00049(acsE)
CTHI: THC_1765
 » show all
Taxonomy
Reference
1  [PMID:7928975]
  Authors
Roberts DL, Zhao S, Doukov T, Ragsdale SW
  Title
The reductive acetyl coenzyme A pathway: sequence and heterologous expression of  active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum.
  Journal
J Bacteriol 176:6127-30 (1994)
DOI:10.1128/JB.176.19.6127-6130.1994
  Sequence
[mta:Moth_1197]
Reference
2  [PMID:10997901]
  Authors
Doukov T, Seravalli J, Stezowski JJ, Ragsdale SW
  Title
Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
  Journal
Structure 8:817-30 (2000)
DOI:10.1016/S0969-2126(00)00172-6
  Sequence
[mta:Moth_1197]
Reference
3  [PMID:17172470]
  Authors
Doukov TI, Hemmi H, Drennan CL, Ragsdale SW
  Title
Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in  activation of methyl transfer by methyltransferases.
  Journal
J Biol Chem 282:6609-18 (2007)
DOI:10.1074/jbc.M609828200
  Sequence
[mta:Moth_1197]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.258
IUBMB Enzyme Nomenclature: 2.1.1.258
ExPASy - ENZYME nomenclature database: 2.1.1.258
BRENDA, the Enzyme Database: 2.1.1.258

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