KEGG   ENZYME: 2.1.1.261Help
Entry
EC 2.1.1.261                Enzyme                                 

Name
4-dimethylallyltryptophan N-methyltransferase;
fgaMT (gene name);
easF (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine [RN:R10166]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4-dimethylallyl-L-tryptophan [CPD:C04290]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4-dimethylallyl-L-abrine [CPD:C20410]
Comment
The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.
History
EC 2.1.1.261 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K18884  4-dimethylallyltryptophan N-methyltransferase
Genes
MAW: MAC_06987
MAJ: MAA_06738
PLJ: VFPFJ_09684
GLZ: GLAREA_05928
AFM: AFUA_2G18060
ABE: ARB_04647
TVE: TRV_01861
Taxonomy
Reference
1  [PMID:18678866]
  Authors
Rigbers O, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.
  Journal
J Biol Chem 283:26859-68 (2008)
DOI:10.1074/jbc.M804979200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.261
IUBMB Enzyme Nomenclature: 2.1.1.261
ExPASy - ENZYME nomenclature database: 2.1.1.261
BRENDA, the Enzyme Database: 2.1.1.261

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