| Entry |
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| Name |
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN: R04033]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
phenylethanolamine [CPD: C02735]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N-methylphenylethanolamine [CPD: C03711]
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| Comment |
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
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| History |
EC 2.1.1.28 created 1972
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| Pathway |
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| Orthology |
| K00553 | phenylethanolamine N-methyltransferase |
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| Genes |
» show all
 |
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| Reference |
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| Authors |
AXELROD J. |
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| Title |
Purification and properties of phenylethanolamine-N-methyl transferase. |
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| Journal |
J Biol Chem 237:1657-60 (1962) |
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| Reference |
|
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| Authors |
Connett RJ, Kirshner N. |
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| Title |
Purification and properties of bovine phenylethanolamine N-methyltransferase. |
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| Journal |
J Biol Chem 245:329-34 (1970) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.28 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.28 |
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