Entry |
|
Name |
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
|
Reaction(IUBMB) |
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN: R04033]
|
Reaction(KEGG) |
|
Substrate |
S-adenosyl-L-methionine [CPD: C00019];
phenylethanolamine [CPD: C02735]
|
Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N-methylphenylethanolamine [CPD: C03711]
|
Comment |
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
|
History |
EC 2.1.1.28 created 1972
|
Pathway |
|
Orthology |
K00553 | phenylethanolamine N-methyltransferase |
|
Genes |
» show all
|
Reference |
|
Authors |
AXELROD J. |
Title |
Purification and properties of phenylethanolamine-N-methyl transferase. |
Journal |
J Biol Chem 237:1657-60 (1962) |
Reference |
|
Authors |
Connett RJ, Kirshner N. |
Title |
Purification and properties of bovine phenylethanolamine N-methyltransferase. |
Journal |
J Biol Chem 245:329-34 (1970) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.1.1.28 |
ExPASy - ENZYME nomenclature database: | 2.1.1.28 |
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