KEGG   ENZYME: 2.1.1.28Help
Entry
EC 2.1.1.28                 Enzyme                                 

Name
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033]
Reaction(KEGG)
R04033;
(other) R02533
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711]
Comment
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
History
EC 2.1.1.28 created 1972
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00553  phenylethanolamine N-methyltransferase
Genes
HSA: 5409(PNMT)
PTR: 454634(PNMT)
PPS: 100978896(PNMT)
GGO: 101140487(PNMT)
PON: 100450669(PNMT)
NLE: 100603046(PNMT)
MCC: 697444(PNMT)
MCF: 102144850(PNMT)
CSAB: 103243536(PNMT)
RRO: 104674852(PNMT)
RBB: 108527783(PNMT)
CJC: 100405480(PNMT)
SBQ: 101032723(PNMT)
MMU: 18948(Pnmt)
RNO: 24661(Pnmt)
CGE: 100768410(Pnmt)
NGI: 103743823(Pnmt)
HGL: 101706187(Pnmt)
CCAN: 109694115(Pnmt)
OCU: 100355890(PNMT)
TUP: 102501155(PNMT)
CFA: 491023(PNMT)
AML: 100480535(PNMT)
UMR: 103662175(PNMT)
ORO: 101365469(PNMT)
FCA: 101101350(PNMT)
PTG: 102961408(PNMT)
AJU: 106980500(PNMT)
BTA: 281413(PNMT)
BOM: 102267416(PNMT)
BIU: 109574122(PNMT)
PHD: 102319588(PNMT)
CHX: 102175988(PNMT)
OAS: 101103826(PNMT)
SSC: 100144479(PNMT)
CFR: 102520076(PNMT)
CDK: 105099042(PNMT)
BACU: 103001658(PNMT)
LVE: 103074918(PNMT)
OOR: 101283122(PNMT)
ECB: 100033859(PNMT)
EPZ: 103550153(PNMT)
EAI: 106826394(PNMT)
MYB: 102249392(PNMT)
MYD: 102758984(PNMT)
HAI: 109380659(PNMT)
RSS: 109455808(PNMT)
LAV: 100655935(PNMT)
TMU: 101355696
MDO: 100017260(PNMT)
SHR: 100928301(PNMT)
OAA: 100079586(PNMT)
GGA: 100858738(PNMT)
MGP: 104914599(PNMT) 104916482
CJO: 107325268(PNMT)
TGU: 100228437(PNMT)
GFR: 102031976(PNMT)
FAB: 101806263(PNMT)
PHI: 102110801(PNMT)
PMAJ: 107215073(PNMT)
CCAE: 111944131
FPG: 101914742(PNMT)
CLV: 102096197(PNMT)
AAM: 106486172(PNMT)
ASN: 102370069(PNMT)
AMJ: 102558831(PNMT)
PSS: 102456862(PNMT)
CMY: 102946470(PNMT)
CPIC: 101947293(PNMT)
ACS: 100565710(pnmt)
PVT: 110082064(PNMT)
PBI: 103057808(PNMT)
GJA: 107114737(PNMT)
XLA: 108700775(pnmt.L) 108702360(pnmt.S)
XTR: 100492236(pnmt)
NPR: 108792760(PNMT)
DRE: 100332609
SRX: 107716495(pnmt)
SANH: 107676565
SGH: 107571312
CCAR: 109092887
IPU: 108273631
AMEX: 103022410
TRU: 101068284(pnmt)
NCC: 104943468(pnmt) 104960380
MZE: 101478707(pnmt)
OLA: 101172030(pnmt)
XMA: 102217979(pnmt)
PRET: 103481424(pnmt)
NFU: 107387578(pnmt)
KMR: 108247644(pnmt)
CSEM: 103381482(pnmt)
LCF: 108901731(pnmt)
SDU: 111220132(pnmt)
HCQ: 109513412(pnmt)
BPEC: 110154403(pnmt)
MALB: 109962872(pnmt)
SASA: 106579371(pnmt)
OTW: 112223306(pnmt)
ELS: 105006836(pnmt)
SFM: 108919132(pnmt)
LCM: 102365914(PNMT)
CMK: 103183857(pnmt)
 » show all
Taxonomy
Reference
1  [PMID:13863458]
  Authors
AXELROD J.
  Title
Purification and properties of phenylethanolamine-N-methyl transferase.
  Journal
J Biol Chem 237:1657-60 (1962)
Reference
2  [PMID:5412063]
  Authors
Connett RJ, Kirshner N.
  Title
Purification and properties of bovine phenylethanolamine N-methyltransferase.
  Journal
J Biol Chem 245:329-34 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.28
IUBMB Enzyme Nomenclature: 2.1.1.28
ExPASy - ENZYME nomenclature database: 2.1.1.28
BRENDA, the Enzyme Database: 2.1.1.28
CAS: 9037-68-7

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