KEGG ENZYME: 2.1.1.28

ENZYME: 2.1.1.28

Entry

EC 2.1.1.28 Enzyme

Name

phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033]

Reaction(KEGG)

R04033;
(other) R02533

Substrate

S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711]

Comment

Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

History

EC 2.1.1.28 created 1972

Pathway

ec00350

Tyrosine metabolism

ec01100

Metabolic pathways

Orthology

K00553

phenylethanolamine N-methyltransferase

Genes

HSA:	5409(PNMT)

PTR:	454634(PNMT)

PPS:	100978896(PNMT)

GGO:	101140487(PNMT)

PON:	100450669(PNMT)

NLE:	100603046(PNMT)

MCC:	697444(PNMT)

MCF:	102144850(PNMT)

CSAB:

103243536(PNMT)

RRO:	104674852(PNMT)

RBB:	108527783(PNMT)

CJC:	100405480(PNMT)

SBQ:	101032723(PNMT)

MMU:	18948(Pnmt)

MCAL:

110306272(Pnmt)

MPAH:

110332744(Pnmt)

RNO:	24661(Pnmt)

MUN:	110562946(Pnmt)

CGE:	100768410(Pnmt)

NGI:	103743823(Pnmt)

HGL:	101706187(Pnmt)

CCAN:

109694115(Pnmt)

OCU:	100355890(PNMT)

TUP:	102501155(PNMT)

VVP:	112918118(PNMT)

AML:	100480535(PNMT)

UMR:	103662175(PNMT)

UAH:	113265179(PNMT)

ORO:	101365469(PNMT)

ELK:

111151828

FCA:	101101350(PNMT)

PTG:	102961408(PNMT)

PPAD:

109247421(PNMT)

AJU:	106980500(PNMT)

BTA:	281413(PNMT)

BOM:	102267416(PNMT)

BIU:	109574122(PNMT)

BBUB:

102410415(PNMT)

CHX:	102175988(PNMT)

OAS:	101103826(PNMT)

SSC:	100144479(PNMT)

CFR:	102520076(PNMT)

CDK:	105099042(PNMT)

BACU:

103001658(PNMT)

LVE:	103074918(PNMT)

OOR:	101283122(PNMT)

DLE:	111166487(PNMT)

PCAD:

102991209(PNMT)

ECB:	100033859(PNMT)

EPZ:	103550153(PNMT)

EAI:	106826394(PNMT)

MYB:	102249392(PNMT)

MYD:	102758984(PNMT)

MNA:	107528967(PNMT)

HAI:	109380659(PNMT)

DRO:	112316421(PNMT)

PALE:

102883108 102885798

RAY:	107520713(PNMT)

MJV:	108390001(PNMT)

LAV:	100655935(PNMT)

TMU:

101355696

MDO:	100017260(PNMT)

SHR:	100928301(PNMT)

PCW:	110215827(PNMT)

OAA:	100079586(PNMT)

GGA:	100858738(PNMT)

MGP:	104914599(PNMT) 104916482

CJO:	107325268(PNMT)

NMEL:

110388710(PNMT)

APLA:

113840035(PNMT)

TGU:	100228437(PNMT)

LSR:	110471932(PNMT)

GFR:	102031976(PNMT)

PHI:	102110801(PNMT)

CCAE:

111944131

ETL:	114071804(PNMT)

NNI:	104017695(PNMT)

ASN:	102370069(PNMT)

AMJ:	102558831(PNMT)

CMY:	102946470(PNMT)

CPIC:

101947293(PNMT)

ACS:	100565710(pnmt)

PVT:	110082064(PNMT)

PBI:	103057808(PNMT)

PMUR:

107303015(PNMT)

TSR:	106538850(PNMT)

PMUA:

114582804(PNMT)

GJA:	107114737(PNMT)

XLA:	108700775(pnmt.L) 108702360(pnmt.S)

XTR:	100492236(pnmt)

NPR:	108792760(PNMT)

DRE:

100332609

SRX:	107716495(pnmt)

SANH:

SGH:

CCAR:

IPU:

PHYP:

113535195(pnmt)

AMEX:

103022410

EEE:	113576882(pnmt)

TRU:	101068284(pnmt)

LCO:	104922126 104933416

NCC:	104943468(pnmt) 104960380

MZE:	101478707(pnmt)

ONL:	100704948(pnmt)

OLA:	101172030(pnmt)

XMA:	102217979(pnmt)

XCO:	114151774(pnmt)

PRET:

103481424(pnmt)

CVG:	107089993(pnmt)

NFU:	107387578(pnmt)

KMR:

108247644

ALIM:

106516992(pnmt)

AOCE:

111566735(pnmt)

CSEM:

103381482(pnmt)

POV:	109626801(pnmt)

LCF:	108901731(pnmt)

SDU:	111220132(pnmt)

SLAL:

111657100(pnmt)

HCQ:	109513412(pnmt)

BPEC:

110154403(pnmt)

MALB:

109962872(pnmt)

SASA:

106579371(pnmt)

OTW:	112223306(pnmt)

SALP:

111977642(pnmt)

ELS:	105006836(pnmt)

SFM:	108919132(pnmt)

PKI:	111856096(pnmt)

LCM:	102365914(PNMT)

CMK:	103183857(pnmt)

RTP:	109930472(pnmt)

BFO:	118404812 118408157 118411785 118425090 118427144 118428020

ISC:	IscW_ISCW020997

MYI:	110456502 110459317 110459319

BLEP:

AL038_03540

» show all

Reference

1 [PMID:13863458]

Authors

AXELROD J.

Title

Purification and properties of phenylethanolamine-N-methyl transferase.

Journal

J Biol Chem 237:1657-60 (1962)

Reference

2 [PMID:5412063]

Authors

Connett RJ, Kirshner N.

Title

Purification and properties of bovine phenylethanolamine N-methyltransferase.

Journal

J Biol Chem 245:329-34 (1970)

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.28

IUBMB Enzyme Nomenclature:

2.1.1.28

ExPASy - ENZYME nomenclature database:

2.1.1.28

BRENDA, the Enzyme Database:

2.1.1.28

CAS:

9037-68-7

DBGET integrated database retrieval system