KEGG   ENZYME: 2.1.1.299Help
Entry
EC 2.1.1.299                Enzyme                                 

Name
protein N-terminal monomethyltransferase;
NRMT2 (gene name);
METTL11B (gene name);
N-terminal monomethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N-terminal-(A,P,S)PK-[protein]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Comment
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.
History
EC 2.1.1.299 created 2014
Orthology
K19579  protein N-terminal monomethyltransferase
Genes
HSA: 149281(METTL11B)
PTR: 469577(METTL11B)
PPS: 100987718(METTL11B)
GGO: 101152939(METTL11B)
PON: 100444887
NLE: 100586787(METTL11B)
MCC: 705503(METTL11B)
MCF: 102119511(METTL11B)
CSAB: 103230610(METTL11B)
RRO: 104669430(METTL11B)
RBB: 108527263(METTL11B)
CJC: 100411855(METTL11B)
SBQ: 101045661(METTL11B)
MMU: 240879(Mettl11b)
MCAL: 110303799(Mettl11b)
MPAH: 110322511(Mettl11b)
RNO: 289167(Mettl11b)
MUN: 110549919(Mettl11b)
CGE: 100752444(Mettl11b)
NGI: 103727098(Mettl11b)
HGL: 101718425(Mettl11b) 101722032
CCAN: 109691209(Mettl11b)
OCU: 100346292(METTL11B)
TUP: 102475213(METTL11B)
CFA: 490351(METTL11B)
VVP: 112923452(METTL11B)
AML: 100466656(METTL11B)
UMR: 103667791(METTL11B)
UAH: 113262619(METTL11B)
ORO: 101386407(METTL11B)
FCA: 101084764(METTL11B)
PTG: 102967658(METTL11B)
AJU: 106966229(METTL11B)
BTA: 521303(METTL11B)
BOM: 102274395(METTL11B)
BIU: 109570672(METTL11B)
BBUB: 102415209(METTL11B)
PHD: 102320091(METTL11B)
CHX: 102172563(METTL11B)
OAS: 101103252(METTL11B) 114117224
SSC: 100157210(METTL11B)
CFR: 102523187(METTL11B)
CDK: 105092751(METTL11B)
BACU: 103016571(METTL11B)
LVE: 103073590(METTL11B)
OOR: 101289399(METTL11B)
DLE: 111167368(METTL11B)
ECB: 100059169(METTL11B)
EPZ: 103550805(METTL11B)
EAI: 106833811(METTL11B)
MYB: 102255085(METTL11B)
MYD: 102754821(METTL11B)
MNA: 107543739(METTL11B)
HAI: 109385450(METTL11B)
RSS: 109437261(METTL11B)
DRO: 112321237(METTL11B)
PALE: 102885906(METTL11B)
LAV: 100661734(METTL11B)
TMU: 101361457
MDO: 100019985(METTL11B)
SHR: 100922386(METTL11B)
PCW: 110196979(METTL11B)
OAA: 100084060(METTL11B)
GGA: 429066(METTL11B)
MGP: 104909323(METTL11B)
CJO: 107317298(METTL11B)
APLA: 101799335(METTL11B)
ACYG: 106041617(METTL11B)
TGU: 100223826(METTL11B)
LSR: 110478926(METTL11B)
SCAN: 103823381(METTL11B)
GFR: 102040508(METTL11B)
FAB: 101821734(METTL11B)
PHI: 102112950(METTL11B)
PMAJ: 107208356(METTL11B)
CCAE: 111932492(METTL11B)
CCW: 104695457(METTL11B)
ETL: 114063562(METTL11B)
FPG: 101921234(METTL11B)
FCH: 102057343(METTL11B)
CLV: 102084074(METTL11B)
EGZ: 104132065(METTL11B)
NNI: 104010396(METTL11B)
ACUN: 113483115(METTL11B)
AAM: 106493883(METTL11B)
ASN: 102370453(METTL11B)
AMJ: 102575018(METTL11B)
PSS: 102446567(METTL11B)
CMY: 102935596(METTL11B)
CPIC: 101944603(METTL11B)
ACS: 100555292(mettl11b)
PVT: 110090583(METTL11B)
PBI: 103057111(METTL11B)
GJA: 107106117(METTL11B)
XLA: 108713669(mettl11b.L) 108715745(mettl11b.S)
XTR: 100485318(mettl11b)
NPR: 108793700(METTL11B)
DRE: 568419(mettl11b)
SGH: 107553430 107580753 107599113(mettl11b)
IPU: 108257661(mettl11b)
PHYP: 113546860(mettl11b)
AMEX: 103038020(mettl11b)
EEE: 113581064(mettl11b)
TRU: 101074892(mettl11b)
LCO: 104936067(mettl11b)
NCC: 104952141(mettl11b)
MZE: 101485145(mettl11b)
OLA: 101166618(mettl11b)
XMA: 102226777(mettl11b)
XCO: 114141417(mettl11b)
PRET: 103463194(mettl11b)
NFU: 107374283(mettl11b)
KMR: 108247575(mettl11b)
CSEM: 103399314(mettl11b)
LCF: 108883491(mettl11b)
SDU: 111227492(mettl11b)
HCQ: 109523463(mettl11b)
BPEC: 110174554(mettl11b)
MALB: 109965197(mettl11b)
SASA: 106560537(mettl11b) 106584007
OTW: 112251384(mettl11b)
SALP: 111972097 111975411(mettl11b)
ELS: 105011974(mettl11b)
SFM: 108935366(mettl11b)
PKI: 111840065(mettl11b)
LCM: 102347657(METTL11B)
CMK: 103179979(mettl11b)
 » show all
Taxonomy
Reference
1  [PMID:24090352]
  Authors
Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE
  Title
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.
  Journal
Biochem J 456:453-62 (2013)
DOI:10.1042/BJ20131163
  Sequence
[hsa:149281]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.299
IUBMB Enzyme Nomenclature: 2.1.1.299
ExPASy - ENZYME nomenclature database: 2.1.1.299
BRENDA, the Enzyme Database: 2.1.1.299

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