KEGG   ENZYME: 2.1.1.355
Entry
EC 2.1.1.355                Enzyme                                 

Name
[histone H3]-lysine9 N-trimethyltransferase;
KMT1A (gene name);
KMT1B (gene name);
KMT1C (gene name);
KMT1D (gene name);
KMT1F (gene name);
MT8 (gene name);
SUV39H1 (gene name);
G9A (gene name);
EHMT1 (gene name);
PRDM2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-trimethyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
Reaction(KEGG)
(other) R03875 R04866 R04867
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
Comment
This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, and EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase.
History
EC 2.1.1.355 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.355, modified 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11419  [histone H3]-lysine9 N-trimethyltransferase SUV39H
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT
K11432  [histone H3]-lysine9 N-trimethyltransferase PRDM2
K18494  [histone H3]-lysine9 N-trimethyltransferase SETDB2
Genes
HSA: 10919(EHMT2) 6839(SUV39H1) 7799(PRDM2) 79723(SUV39H2) 79813(EHMT1) 83852(SETDB2)
PTR: 107971148(SUV39H1) 452719(SETDB2) 462572(EHMT2) 464891(EHMT1) 466014(SUV39H2) 469125(PRDM2)
PPS: 100968253(EHMT1) 100971376(PRDM2) 100977497(SUV39H1) 100982469(SUV39H2) 100986951(SETDB2) 100991724(EHMT2)
GGO: 101125370(PRDM2) 101126338(SUV39H2) 101139808(EHMT2) 101141713(SETDB2) 101146540(SUV39H1) 101151843(EHMT1)
PON: 100172621(SUV39H1) 100436926(SUV39H2) 100436958(PRDM2) 100437576(SETDB2) 100449422(EHMT1) 100460372(EHMT2)
NLE: 100582767(PRDM2) 100584465(EHMT1) 100591032(SUV39H2) 100593118 100598636(SUV39H1) 100606578(EHMT2)
MCC: 697378(SUV39H2) 706277(SETDB2) 711040(SUV39H1) 715824(EHMT2) 716295(PRDM2) 721470(EHMT1)
MCF: 101926557(PRDM2) 102123944 102124788(SETDB2) 102125769(EHMT1) 102134179(SUV39H1) 102136014(SUV39H2) 102139754(EHMT2)
CSAB: 103214423(SETDB2) 103221737(EHMT2) 103225565(PRDM2) 103231938(SUV39H1) 103237926(SUV39H2) 103239544(EHMT1)
CATY: 105573130(SUV39H1) 105573427(EHMT2) 105580648(EHMT1) 105583853(SUV39H2) 105587753(SETDB2) 105593644(PRDM2) 105598847
PANU: 101002260(SUV39H2) 101003206 101004243(PRDM2) 101007672(SUV39H1) 101023004(SETDB2)
RRO: 104660660(SUV39H1) 104662745(SETDB2) 104664471(SUV39H2) 104669606(EHMT1) 104674046(PRDM2) 104678126(EHMT2)
RBB: 108517467(SUV39H1) 108519969 108520267(EHMT2) 108530731(SETDB2) 108531071(SUV39H2) 108542880(EHMT1)
TFN: 117062164 117063240(SETDB2) 117078273(SUV39H1) 117082672(SUV39H2) 117086972(EHMT2) 117093284(PRDM2) 117099071(EHMT1)
PTEH: 111523081(SETDB2) 111523903(EHMT2) 111528202 111529262(PRDM2) 111535700(SUV39H1) 111550038(SUV39H2) 111553022(EHMT1)
CJC: 100385110(PRDM2) 100394788(SETDB2) 100398057(EHMT1) 100401369(SUV39H1) 100401513(SUV39H2) 100408867(EHMT2)
SBQ: 101040475(SUV39H2) 101043411(SETDB2) 101046305(EHMT2) 101052197(SUV39H1) 101054202(PRDM2) 101054241(EHMT1) 104652487
MMUR: 105856353(SUV39H2) 105856376(SUV39H1) 105858186(EHMT2) 105870432(PRDM2) 105871464 105882234(EHMT1)
MMU: 107303348(Gm45935) 110147(Ehmt2) 110593(Prdm2) 20937(Suv39h1) 239122(Setdb2) 64707(Suv39h2) 77683(Ehmt1)
MCAL: 110284133(Ehmt2) 110287176(Suv39h1) 110289296(Suv39h2) 110293588(Prdm2) 110309030(Setdb2) 110312405(Ehmt1)
MPAH: 110313347(Suv39h1) 110317691(Ehmt1) 110322886(Prdm2) 110325326(Setdb2) 110333642(Suv39h2) 110335935(Ehmt2)
RNO: 100361710(Setdb2) 302553(Suv39h1l1) 313678(Prdm2) 361798(Ehmt2) 362078(Ehmt1) 364785(Suv39h2)
MCOC: 116068177(Suv39h1) 116075347(Ehmt2) 116082667(Suv39h2) 116084077(Setdb2) 116089787(Ehmt1) 116096984(Prdm2)
MUN: 110554698(Suv39h2) 110556467(Prdm2) 110560108(Ehmt2) 110561991(Suv39h1)
CGE: 100754544(Ehmt1) 100755145(Suv39h2) 100764568(Suv39h1) 100769417(Ehmt2) 100774155(Setdb2) 103158597(Prdm2)
PLEU: 114686373 114692754(Ehmt1) 114693839(Setdb2) 114700854(Prdm2) 114701015 114701306(Suv39h1) 114705861(Ehmt2) 114710826(Suv39h2)
NGI: 103724422(Ehmt2) 103732609(Ehmt1) 103735184(Suv39h2) 103741644(Suv39h1) 103752332(Prdm2)
HGL: 101696702(Setdb2) 101697232(Ehmt2) 101699104(Ehmt1) 101699822(Prdm2) 101701917(Suv39h2) 101706867(Suv39h1)
CPOC: 100716644(Prdm2) 100717131 100728513(Suv39h2) 100728628(Ehmt2) 100731248(Suv39h1) 100735478(Ehmt1)
CCAN: 109688969(Ehmt1) 109689573(Ehmt2) 109691104(Setdb2) 109691500(Suv39h2) 109701207(Suv39h1) 109702677(Prdm2)
OCU: 100342335(PHF11) 100348361(EHMT1) 100350859 100354725(SUV39H1) 100355131(EHMT2) 100358024(SUV39H2) 103352508(PRDM2)
OPI: 101516403(SUV39H2) 101519409(EHMT2) 101522414(EHMT1) 101529760 101533434(PRDM2) 101533574(SUV39H1)
TUP: 102468719(SUV39H1) 102472765 102479735(EHMT2) 102498729(EHMT1) 102499550(PRDM2) 102503290(SETDB2)
CFA: 100688431(PRDM2) 474851(EHMT2) 477995(SUV39H2) 485441(SETDB2) 491224(EHMT1) 491868(SUV39H1)
VVP: 112907242(SUV39H1) 112911417(EHMT1) 112913622(EHMT2) 112929764(PRDM2) 112933120(SUV39H2) 112933943(SETDB2)
VLG: 121472597(EHMT1) 121482956(SUV39H1) 121497217(SUV39H2) 121497868(PRDM2) 121500746(EHMT2)
AML: 100466861(EHMT1) 100468794(EHMT2) 100469547(SUV39H2) 100472595(SUV39H1) 100476962 100481446(PRDM2)
UMR: 103664189(SUV39H2) 103666633(PRDM2) 103666849 103669105(SUV39H1) 103675323(EHMT1) 103677615(SETDB2) 103682289(EHMT2)
UAH: 113241391(SUV39H2) 113243735(EHMT2) 113248390 113248430 113251315 113265922(SUV39H1) 113270485(PRDM2)
ORO: 101364966(PRDM2) 101374258(SUV39H2) 101375740(EHMT1) 101376988(EHMT2) 101381146(SUV39H1) 101381937(SETDB2)
MPUF: 101672446(EHMT1) 101675209(SUV39H1) 101680049(SETDB2) 101684472(PRDM2) 101693123(EHMT2) 101693651(SUV39H2)
EJU: 114201776(EHMT1) 114209727(SETDB2) 114210177 114213314(PRDM2) 114216775(SUV39H1) 114217278(SUV39H2) 114222217(EHMT2)
MLX: 118009449(SETDB2) 118010050(SUV39H1) 118017468(EHMT1) 118019988(PRDM2) 118021560(SUV39H2) 118027316(EHMT2)
FCA: 101082169(PRDM2) 101083571(SUV39H1) 101087111(EHMT1) 101091940(EHMT2) 101099218(SUV39H2)
PYU: 121012940(SETDB2) 121014778(SUV39H2) 121017381(PRDM2) 121020251(EHMT1) 121022333(EHMT2) 121025917(SUV39H1)
PBG: 122473257(SUV39H2) 122474697(EHMT1) 122477943(SUV39H1) 122478262(EHMT2) 122479953(PRDM2) 122482025
PTG: 102950897(SUV39H1) 102954489(EHMT1) 102962904(SETDB2) 102963752(SUV39H2) 102966552 102967892(PRDM2) 102968259(EHMT2)
PPAD: 109248069(SUV39H1) 109260239(EHMT1) 109260503(EHMT2) 109265964 109273698(SUV39H2) 109274376(PRDM2)
AJU: 106970864(SUV39H1) 106971016(SUV39H2) 106972687 106983481(EHMT2) 106988167(PRDM2) 106989056(EHMT1)
HHV: 120221011(SUV39H1) 120221909(EHMT2) 120222801(EHMT1) 120229745(PRDM2) 120236934(SUV39H2) 120245213
BTA: 509382(SETDB2) 514062(EHMT2) 523047(SUV39H1) 528606(EHMT1) 536936(SUV39H2) 789222(PRDM2)
BOM: 102264756(SUV39H2) 102271111(EHMT1) 102271191(SUV39H1) 102279999(EHMT2) 102281203(PRDM2) 102287560(SETDB2)
BIU: 109565691(EHMT1) 109566720(SETDB2) 109567973(SUV39H2) 109570372(PRDM2) 109576929(EHMT2)
BBUB: 102392662(SETDB2) 102395323(EHMT1) 102396138(PRDM2) 102401546(SUV39H1) 102405188(EHMT2) 102415169(SUV39H2)
CHX: 102171636(PRDM2) 102174919(SUV39H1) 102176621(SUV39H2) 102178316(EHMT2) 102186776(SETDB2) 102189411(EHMT1)
OAS: 101110031(SUV39H1) 101115739(EHMT2) 101116064(SETDB2) 101116417(SUV39H2) 101123545(EHMT1) 105601941(PRDM2)
ODA: 120851867(EHMT1) 120869586(SUV39H2) 120870570(EHMT2) 120880549(PRDM2) 120882096(SUV39H1) 120883048(SETDB2)
CCAD: 122429704(EHMT2) 122434492(SUV39H1) 122442444(EHMT1) 122447612 122448086(SUV39H2) 122452565(PRDM2) 122453800
SSC: 100124382(EHMT2) 100157885(SETDB2) 100518559(PRDM2) 110258080(EHMT1) 664651(SUV39H2) 767626(SUV39H1)
CFR: 102514882(PRDM2) 102514903 102518579(EHMT2) 102521199(SUV39H2) 102521526(EHMT1)
CBAI: 105066151(SETDB2) 105070953(PRDM2) 105072449(SUV39H2) 105073403(EHMT1) 105074044(EHMT2) 105079433(SUV39H1)
CDK: 105087443(EHMT2) 105101932 105102102(EHMT1) 105103308(SUV39H1) 105104521(SUV39H2) 105107110(PRDM2)
BACU: 102999710(SUV39H2) 103005831(SUV39H1) 103017152(SETDB2) 103017744(EHMT1) 103018553(EHMT2) 103020862(PRDM2)
LVE: 103068757(SETDB2) 103072310(EHMT2) 103073919(SUV39H1) 103079038(EHMT1) 103083070(PRDM2) 103084616(SUV39H2)
OOR: 101269551(PRDM2) 101272833(EHMT1) 101279239(SUV39H2) 101282385(EHMT2) 101289196(SUV39H1)
DLE: 111169525(SUV39H1) 111170699(EHMT2) 111175303 111176964(EHMT1) 111178089(SUV39H2) 111187234(PRDM2)
PCAD: 102974835(PRDM2) 102978732(EHMT1) 102988226(SUV39H2) 102988363(SUV39H1) 102990347(SETDB2) 102993056(EHMT2)
PSIU: 116742984 116747305(SUV39H1) 116748760(SUV39H2) 116755232(EHMT1) 116758756(PRDM2) 116762596(EHMT2)
ECB: 100054973(PRDM2) 100056120(SETDB2) 100058869(EHMT1) 100059118(EHMT2) 100062108(SUV39H1) 100068891(SUV39H2)
EPZ: 103544360 103544897(SUV39H1) 103554163(EHMT1) 103556824(SUV39H2) 103563300(EHMT2) 103563428(SETDB2) 103564688(PRDM2)
EAI: 106822324(EHMT2) 106822761(EHMT1) 106827436(SUV39H1) 106828015(PRDM2) 106829693(SETDB2) 106840452(SUV39H2)
MYB: 102243180(SUV39H1) 102245485(EHMT1) 102248401(SETDB2) 102249747(PRDM2) 102260054(SUV39H2) 102263672(EHMT2)
MYD: 102756540(EHMT1) 102757145(SUV39H2) 102760935(PRDM2) 102763954(SUV39H1) 102765299(SETDB2) 102773857(EHMT2)
MMYO: 118650813(SETDB2) 118653933(SUV39H1) 118655270(EHMT1) 118655474(SUV39H2) 118675978(PRDM2) 118679573(EHMT2)
MLF: 102416827(EHMT2) 102417028(PRDM2) 102417065(EHMT1) 102425465(SUV39H1) 102432659(SUV39H2) 102439374(SETDB2)
MNA: 107531408(SETDB2) 107531564 107534821(SUV39H2) 107536199(EHMT1) 107538997(EHMT2) 107541392(SUV39H1)
PKL: 118705352(EHMT2) 118707004(EHMT1) 118724641(PRDM2) 118730016(SETDB2) 118731722(SUV39H2) 118731771(SUV39H1)
HAI: 109373117(EHMT2) 109374812(SUV39H1) 109381271(PRDM2) 109382055(EHMT1) 109387125(SETDB2) 109393823(SUV39H2)
DRO: 112299124(PRDM2) 112302258(EHMT2) 112306260(EHMT1) 112313171 112320455(SUV39H2) 112322458(SUV39H1)
SHON: 118980361(EHMT1) 118981134(SETDB2) 118986328(PRDM2) 118987556(EHMT2) 118997120(SUV39H2) 118998320(SUV39H1)
AJM: 119036154(EHMT1) 119046306(SUV39H2) 119053719(EHMT2) 119056191(PHF11) 119056213 119059808(SUV39H1) 119064074(PRDM2)
PDIC: 114492683(SUV39H2) 114493954(EHMT2) 114497456(PRDM2) 114503245(EHMT1) 114504865(SUV39H1) 114508743(SETDB2)
MMF: 118621070(EHMT2) 118622825(SETDB2) 118627031(PRDM2) 118629406(EHMT1) 118636303(SUV39H1) 118643229(SUV39H2)
RFQ: 117019247(SUV39H2) 117020464(EHMT2) 117021802(SETDB2) 117026590(PRDM2) 117027799(SUV39H1) 117031680(EHMT1)
PALE: 102879374(EHMT2) 102879589(PRDM2) 102891996 102893102(EHMT1) 102894853(SUV39H1) 102898400(SUV39H2)
PGIG: 120583855 120585797(PRDM2) 120587091(SUV39H1) 120599828(EHMT1) 120614623(SUV39H2) 120618905(EHMT2)
PVP: 105291688(SUV39H2) 105294353(PRDM2) 105298547(EHMT1) 105298868 105305296(EHMT2) 105310010(SUV39H1)
RAY: 107498490(EHMT2) 107503067(EHMT1) 107504834(SUV39H2) 107510017(SETDB2) 107513143(PRDM2) 107515026(SUV39H1)
MJV: 108397103(SUV39H2) 108397963(PRDM2) 108400840(EHMT2) 108403560(SETDB2) 108408400(SUV39H1)
TOD: 119230503(EHMT1) 119236551(PRDM2) 119244708(SUV39H2) 119246174(SUV39H1) 119252227(EHMT2) 119258894(SETDB2)
LAV: 100653780(SUV39H1) 100658021(PRDM2) 100659207(EHMT2) 100670438 100674328(SUV39H2)
MDO: 100010516(PRDM2) 100014806(SUV39H2) 100018670(SUV39H1) 100023838(EHMT1) 100025360(EHMT2) 100028710(SETDB2)
GAS: 123237182(EHMT1) 123240320(PRDM2) 123241246(SETDB2) 123246359(EHMT2) 123249577(SUV39H2) 123254217(SUV39H1)
SHR: 100922258(SUV39H1) 100931147(EHMT2) 100932927(EHMT1) 100933751(SUV39H2) 100934863 111719909(PRDM2)
PCW: 110198885(PRDM2) 110199440(EHMT2) 110201087(SUV39H1) 110205249(EHMT1) 110213411(SETDB2) 110217388(SUV39H2)
OAA: 100078328(EHMT1) 100082943(EHMT2) 100083315(SETDB2) 100084051(SUV39H1) 100085175(SUV39H2) 100681503(PRDM2)
GGA: 112529925 112529927(SUV39H1) 417250(EHMT1) 418866(SETDB2) 419478(PRDM2) 426314(SUV39H2)
PCOC: 116226677(SUV39H2) 116234163(EHMT1) 116240919(SUV39H1) 116242576(PRDM2) 116244100
CJO: 107307203(SUV39H1) 107308162 107319605(SUV39H2) 107321652(EHMT1) 107323354(PRDM2)
NMEL: 110391539(SUV39H1) 110392282(SUV39H2) 110406734(EHMT1) 110408674(PRDM2)
APLA: 101790074 101795723(PRDM2) 101796000(SUV39H2) 101805087(EHMT1)
ACYG: 106037080(EHMT1) 106040216(PRDM2) 106040219 106046190(SUV39H2)
TGU: 100217666(EHMT1) 100222565 100225827(SUV39H2) 100231131
LSR: 110469585 110470972(SUV39H2) 110476787(PRDM2) 110476956(EHMT1) 110481760(SUV39H1)
SCAN: 103813741(SUV39H2) 103819172(EHMT1) 103820835 103827401
PMOA: 120504860(EHMT2) 120505766 120507404(EHMT1) 120508289(SUV39H1) 120509265(SUV39H2) 120510997(PRDM2)
OTC: 121336951(EHMT1) 121337331 121339649(SUV39H1) 121340539(SUV39H2) 121343880(PRDM2)
PRUF: 121351466(SUV39H1) 121353285(SETDB2) 121357548(EHMT1) 121358406(PRDM2) 121362326(SUV39H2)
GFR: 102031848(SUV39H2) 102036198(EHMT1) 106631968(PRDM2)
FAB: 101806838(EHMT1) 101812782(PRDM2) 101812936(PHF11) 101814584 101816158(SUV39H2)
PHI: 102099526(EHMT1) 102104074(SETDB2) 102110616(SUV39H1) 102111894(PRDM2) 102114300(SUV39H2)
PMAJ: 107204624(SUV39H2) 107211503 107212039(EHMT1) 107213672(PRDM2)
CCAE: 111923103(SUV39H2) 111935294 111936927(EHMT1) 111938730(PRDM2)
CCW: 104688230(EHMT1) 104689965 104693366(PRDM2) 104694491(SUV39H2)
ETL: 114065121(PRDM2) 114067139(EHMT1) 114067551(SUV39H2)
FPG: 101912815(SUV39H2) 101914490(PRDM2) 101916063(EHMT1) 101917763(SETDB2) 106112052
FCH: 102055395 102057247(EHMT1) 102059458(SUV39H2) 102059903 106631029(PRDM2)
CLV: 102085960(EHMT1) 102088543 102092575(PRDM2) 102098917(SUV39H2)
EGZ: 104124045(EHMT1) 104132393(SUV39H2) 104133098(PRDM2)
NNI: 104009017 104009090 104014630(SUV39H2) 104022219(EHMT1)
ACUN: 113486655(EHMT1) 113487883(PRDM2) 113489768(SUV39H2)
TALA: 104356304(SETDB2) 104358970(SUV39H2) 104366265(EHMT1) 104368416(PRDM2)
PADL: 103915032(SUV39H2) 103918059(PRDM2) 103918930(EHMT1)
AAM: 106482427(PRDM2) 106482431 106485143(SUV39H2) 106493032(EHMT1)
AROW: 112963025(EHMT1) 112970039(PRDM2) 112970710 112978060(SUV39H2)
NPD: 112942367(SUV39H2) 112955805(EHMT1) 112959302 112959576(PRDM2)
DNE: 112980527(PRDM2) 112988137 112991335(EHMT1) 112994764(SUV39H2)
ASN: 102371718(PRDM2) 102374916(EHMT1) 102375358(SUV39H2) 102378805(SUV39H1) 102380189 102381770(EHMT2)
AMJ: 102558468(SUV39H1) 102561958(PRDM2) 102563656(SUV39H2) 102564850(EHMT1) 102574756(EHMT2) 102576351(SETDB2)
CPOO: 109306531 109313837(EHMT1) 109314387(PRDM2) 109315785(SUV39H2)
GGN: 109292195(SUV39H2) 109292861(EHMT1) 109293777(PRDM2) 109302245
PSS: 102444308 102449381 102450225(EHMT1) 102450951 102454204(SUV39H2) 102462370(SUV39H1)
CMY: 102932781 102933671(EHMT1) 102937045(SUV39H2) 102937831(SUV39H1) 102942942(PRDM2)
CPIC: 101939547(PRDM2) 101942163(EHMT1) 101945875(SUV39H2) 101947321(EHMT2) 101950365 101951503(SUV39H1)
TST: 117867970(PRDM2) 117874798(SUV39H2) 117881025 117889342(EHMT1)
CABI: 116815182 116816188(EHMT1) 116818898(SUV39H1) 116821893(PRDM2) 116829773(SETDB2) 116836408(SUV39H2)
MRV: 120386712(EHMT1) 120387701(PRDM2) 120388525(SUV39H1) 120392432(EHMT2) 120395171(SUV39H2) 120403759
ACS: 100552443(setdb2) 100553897(suv39h1) 100556375(ehmt2) 100565730(ehmt1) 100567365(prdm2)
PVT: 110072610 110081193(SUV39H1) 110088696(EHMT2) 110089799(EHMT1)
SUND: 121921274(EHMT2) 121921808(SETDB2) 121922732(SUV39H1) 121936454(EHMT1) 121936691(PRDM2)
PBI: 103049261(EHMT2) 103052540(SUV39H1) 103053645 103057390(EHMT1) 103060604(PRDM2) 103067345
PMUR: 107291380(PRDM2) 107295037(EHMT2) 107300048(SUV39H1)
TSR: 106546114(SUV39H1) 106553032(PRDM2)
PGUT: 117667837(EHMT2) 117669682(PRDM2) 117670273(EHMT1) 117671092(SETDB2) 117675420(SUV39H1)
VKO: 123017991(EHMT2) 123023976(SUV39H1) 123028253(EHMT1) 123030900 123034699(PRDM2)
PMUA: 114588136(SUV39H1) 114589035(EHMT1) 114592073(EHMT2) 114593254(SETDB2) 114602405(PRDM2)
ZVI: 118081033(EHMT2) 118082803 118083831(EHMT1) 118086377(PRDM2) 118097686(SUV39H1)
GJA: 107105480(EHMT2) 107106223(PRDM2) 107112843(SUV39H1) 107118801(EHMT1)
XLA: 100037174(suv39h2.L) 108696585(prdm2.L) 108698163(ehmt1.L) 108698559(ehmt2.L) 108699889(ehmt1.S) 108700299(suv39h1.S) 108713053(suv39h2.S) 398711(setdb2.S) 431943(suv39h1.L) 494709(prdm2.S)
XTR: 100124713(ehmt1) 100124743(setdb2) 100170624(prdm2) 100484992(ehmt2) 116408207 549262(suv39h2)
NPR: 108783946(PRDM2) 108786543(EHMT2) 108788266(SUV39H1) 108794066(SUV39H2) 108797823(SETDB2)
DRE: 100003615(prdm2a) 100005761(ehmt1a) 326906(suv39h1b) 335153(setdb2) 402830(ehmt1b) 445198(suv39h1a) 569250(ehmt2) 797296(prdm2b)
NCC: 104944159(ehmt1) 104951536(prdm2) 104953540(suv39h1) 104955184 104964983(ehmt2)
ELY: 117250033(setdb2) 117252502(ehmt1a) 117256851(prdm2b) 117258208 117258367(prdm2a) 117264216(ehmt2) 117269706(ehmt1b)
PLEP: 121944074(ehmt1a) 121946768(prdm2a) 121947007 121957927(ehmt2) 121957965(prdm2b) 121963043
SLUC: 116034715(ehmt1b) 116040743(prdm2a) 116047257(ehmt2) 116050659(ehmt1a) 116050881 116051293(prdm2b) 116064668(setdb2)
ECRA: 117943501(prdm2b) 117944728(ehmt1a) 117947313(prdm2a) 117948101 117956281(ehmt2) 117959394(ehmt1b)
GAT: 120817503(setdb2) 120826184(ehmt2) 120829224 120829287(prdm2a) 120830284(ehmt1a) 120831490(ehmt1b) 120834707(prdm2b)
PPUG: 119212621(setdb2) 119219094(ehmt2) 119222142 119222294 119223718 119225062(ehmt1a) 119226286(ehmt1b) 119229900(prdm2b)
CUD: 121506434(setdb2) 121506728(prdm2b) 121510414(ehmt1a) 121517416(prdm2a) 121518164 121523685(ehmt2) 121525182(ehmt1b)
ONL: 100691163 100693758(suv39h1) 100697429(prdm2) 100697605(ehmt2) 100700166(ehmt1) 102080474 102081996(creg1)
OAU: 116309719(prdm2a) 116311434 116317088 116318920(ehmt2) 116319606(ehmt1b) 116325005(setdb2) 116334173(prdm2b) 116336331(ehmt1a)
OML: 112140032 112141389 112145067(prdm2b) 112156758(setdb2) 112159425(prdm2a) 112162481(ehmt2) 112163195(ehmt1b)
XMA: 102218201(suv39h1) 102218386 102219854(ehmt1) 102225394 102225694(prdm2) 102232589(ehmt2)
GAF: 122819180(ehmt1b) 122820970 122827065(setdb2) 122827704(ehmt1a) 122834038(prdm2b) 122835996(prdm2a) 122837012 122843390(ehmt2)
CVG: 107083748(ehmt1) 107086188(ehmt2) 107088877 107089331(prdm2) 107090999(suv39h1) 107099179
CTUL: 119771641(ehmt1a) 119772770(prdm2b) 119778038(ehmt2) 119785162(ehmt1b) 119786878 119791609(setdb2) 119797063(prdm2a)
KMR: 108228258(setdb2) 108231376(prdm2b) 108231967 108236789(prdm2a) 108243867(ehmt2) 108249279(ehmt1b) 108251110(ehmt1a)
CSEM: 103384853(suv39h1) 103384937 103385671(prdm2) 103389803(setdb2) 103394057(ehmt2) 103397363
SSEN: 122758215 122765311(setdb2) 122768289(prdm2b) 122769887 122777264(prdm2a) 122777668 122786699(ehmt2)
HHIP: 117761533(prdm2b) 117764108(prdm2a) 117765148(suv39h1a) 117767818(ehmt1a) 117770075(ehmt2) 117771793(ehmt1b) 117772857(setdb2)
XGL: 120786732(ehmt2) 120797954(setdb2) 120803707(prdm2a) 120804350 120805368(ehmt1a) 120806320(ehmt1b) 120807380(prdm2b)
BPEC: 110154648(ehmt1) 110156027(suv39h1) 110158800 110166512 110168576(prdm2) 110173288(ehmt2)
SFM: 108918498(prdm2) 108922673(ehmt1) 108924930 108934780(suv39h1) 108935584(ehmt2) 108937739
AANG: 118206310(ehmt1a) 118207876(prdm2a) 118208326(suv39h1a) 118211125(prdm2b) 118212814(ehmt1b) 118223458(setdb2) 118234483(ehmt2)
LOC: 102685370(suv39h1) 102690499(setdb2) 102690974(prdm2) 102691045
LCM: 102351913 102359250(PRDM2) 102360554(SUV39H2) 102361297(EHMT1) 102363588(SETDB2)
RTP: 109911717(setdb2) 109919887(ehmt2) 109921345(suv39h2) 109926709(ehmt1) 109937263(prdm2)
CIN: 100186548
DME: Dmel_CG2995(G9a) Dmel_CG43664(Su(var)3-9)
DER: 6555648
DSE: 6615843
DSI: Dsimw501_GD16494(Dsim_GD16494)
DSR: 110180428
DGR: 6565756
DVI: 6633588
ACOZ: 120947352
AAG: 5573963
AME: 413388
ALAB: 122716460
BIM: 100740627
CCAL: 108623497
ACEP: 105619940
DAM: 107035556
LDC: 111508362
BMOR: 101743644
PPOT: 106107761
PXU: 106117388
HAW: 110370326
TNL: 113498295
HHAL: 106685924
NLU: 111060381
PVM: 113827542
CSCU: 111614908
TSP: Tsp_05330
EPA: 110242114
ADF: 107356587
AMIL: 114953395
PDAM: 113686615
SPIS: 111341162
DGT: 114521829
ATH: AT2G22740(SUVH6) AT2G33290(SUVH2) AT2G35160(SUVH5) AT4G13460(SUVH9) AT5G13960(SUVH4)
LJA: Lj1g3v3904410.1(Lj1g3v3904410.1) Lj2g3v1989010.1(Lj2g3v1989010.1)
NCOL: 116265645
DOSA: Os01t0927000-01(Os01g0927000) Os07t0435900-01(Os07g0435900) Os08t0565700-01(Os08g0565700) Os09t0362900-01(Os09g0362900)
OLU: OSTLU_25709(SDG3507)
NCR: NCU04402(dim-5)
NTE: NEUTE1DRAFT121214(NEUTE1DRAFT_121214)
MGR: MGG_06852
SSCK: SPSK_07647
NHE: NECHADRAFT_94199(SDG2104)
MAW: MAC_09094
MAJ: MAA_00272
CMT: CCM_00746
BFU: BCIN_11g02360(BcDIM5)
MBE: MBM_05751
ANI: AN1170.2
ANG: ANI_1_1828074(An08g03380)
ABE: ARB_02816
TVE: TRV_01916
PTE: PTT_11395
ZTR: MYCGRDRAFT_107709(SDG2411)
SPO: SPBC428.08c(clr4)
CNE: CNH00720
CNB: CNBL0680
TASA: A1Q1_02905
LBC: LACBIDRAFT_296206(SDG16210) LACBIDRAFT_300409(SDG16205)
ABP: AGABI1DRAFT108076(AGABI1DRAFT_108076) AGABI1DRAFT129982(AGABI1DRAFT_129982)
ABV: AGABI2DRAFT146074(AGABI2DRAFT_146074) AGABI2DRAFT180791(AGABI2DRAFT_180791)
 » show all
Reference
1  [PMID:11094092]
  Authors
O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T
  Title
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase  gene that displays testis-specific expression.
  Journal
Mol Cell Biol 20:9423-33 (2000)
DOI:10.1128/mcb.20.24.9423-9433.2000
  Sequence
[mmu:20937 64707]
Reference
2  [PMID:11867540]
  Authors
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G
  Title
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
  Journal
EMBO J 21:1121-31 (2002)
DOI:10.1093/emboj/21.5.1121
  Sequence
Reference
3  [PMID:12130538]
  Authors
Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y
  Title
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
  Journal
Genes Dev 16:1779-91 (2002)
DOI:10.1101/gad.989402
  Sequence
[mmu:110147]
Reference
4  [PMID:11959841]
  Authors
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd
  Title
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase  that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
  Journal
Genes Dev 16:919-32 (2002)
DOI:10.1101/gad.973302
  Sequence
[hsa:9869]
Reference
5  [PMID:14633678]
  Authors
Kim KC, Geng L, Huang S
  Title
Inactivation of a histone methyltransferase by mutations in human cancers.
  Journal
Cancer Res 63:7619-23 (2003)
  Sequence
[hsa:7799]
Reference
6  [PMID:20084102]
  Authors
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M
  Title
Structural biology of human H3K9 methyltransferases.
  Journal
PLoS One 5:e8570 (2010)
DOI:10.1371/journal.pone.0008570
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.355
IUBMB Enzyme Nomenclature: 2.1.1.355
ExPASy - ENZYME nomenclature database: 2.1.1.355
BRENDA, the Enzyme Database: 2.1.1.355

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