KEGG   ENZYME: 2.1.1.49Help
Entry
EC 2.1.1.49                 Enzyme                                 

Name
amine N-methyltransferase;
nicotine N-methyltransferase;
tryptamine N-methyltransferase;
arylamine N-methyltransferase;
tryptamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:amine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine [RN:R02808]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
amine [CPD:C00706]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylated amine [CPD:C02436]
Comment
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.
History
EC 2.1.1.49 created 1976, modified 1990 (EC 2.1.1.81 created 1989, incorporated 1990)
Pathway
ec00380  Tryptophan metabolism
Orthology
K00562  methyltransferase
Genes
HSA: 11185(INMT)
PTR: 463912(INMT)
PPS: 100986665(INMT)
GGO: 101143120(INMT)
PON: 100171421(INMT)
NLE: 100603670(INMT)
MCC: 694969(INMT)
MCF: 102139220(INMT)
CSAB: 103226272(INMT)
RRO: 104663737(INMT)
RBB: 108532381(INMT)
CJC: 100387750(INMT)
SBQ: 101035075(INMT)
MMU: 21743(Inmt)
RNO: 368066(Inmt)
CGE: 100773805(Inmt)
NGI: 103729450(Inmt)
HGL: 101710622(Inmt) 106008943
OCU: 100008695(INMT) 100338404
TUP: 102502473(INMT)
ORO: 105758206(INMT)
BTA: 527922(INMT)
BOM: 102270640(INMT)
BIU: 109557473(INMT)
PHD: 102341357
CHX: 102186084
SSC: 100512997(INMT)
CFR: 102503927(INMT)
CDK: 105095849(INMT) 105106408
BACU: 103019292
LVE: 103070876
OOR: 101284322(INMT)
ECB: 100055070
EPZ: 103541247(INMT)
EAI: 106830978 106831065(INMT)
LAV: 100671921(INMT)
TMU: 101350596
ACS: 100553677
XTR: 548447 594924(inmt)
MYI: 110462853
ADF: 107342266
 » show all
Taxonomy
Reference
1  [PMID:3949799]
  Authors
Ansher SS, Jakoby WB.
  Title
Amine N-methyltransferases from rabbit liver.
  Journal
J Biol Chem 261:3996-4001 (1986)
Reference
2  [PMID:3377829]
  Authors
Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB.
  Title
Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
  Journal
Biochem Pharmacol 37:1673-7 (1988)
DOI:10.1016/0006-2952(88)90426-1
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.49
IUBMB Enzyme Nomenclature: 2.1.1.49
ExPASy - ENZYME nomenclature database: 2.1.1.49
BRENDA, the Enzyme Database: 2.1.1.49
CAS: 51377-47-0 111694-10-1

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