KEGG   ENZYME: 2.1.1.49
Entry
EC 2.1.1.49                 Enzyme                                 

Name
amine N-methyltransferase;
nicotine N-methyltransferase;
tryptamine N-methyltransferase;
arylamine N-methyltransferase;
tryptamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:amine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine [RN:R02808]
Reaction(KEGG)
R02808 > R02174 R02910;
(other) R08537
Substrate
S-adenosyl-L-methionine [CPD:C00019];
amine [CPD:C00706]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylated amine [CPD:C02436]
Comment
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.
History
EC 2.1.1.49 created 1976, modified 1990 (EC 2.1.1.81 created 1989, incorporated 1990)
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00562  methyltransferase
Genes
HSA: 11185(INMT)
PTR: 463912(INMT)
PPS: 100986665(INMT)
GGO: 101143120(INMT)
PON: 100171421(INMT)
NLE: 100603670(INMT)
MCC: 694969(INMT)
MCF: 102139220(INMT)
CSAB: 103226272(INMT)
RRO: 104663737(INMT)
RBB: 108532381(INMT)
CJC: 100387750(INMT)
SBQ: 101035075(INMT)
MMU: 21743(Inmt)
MCAL: 110296762(Inmt)
MPAH: 110317265(Inmt)
RNO: 368066(Inmt)
MUN: 110555148(Inmt)
CGE: 100773805(Inmt)
NGI: 103729450(Inmt)
HGL: 101710622(Inmt) 106008943
OCU: 100008695(INMT) 100338404
TUP: 102502473(INMT)
ORO: 105758206(INMT)
BTA: 527922(INMT)
BOM: 102270640(INMT)
BIU: 109557473(INMT)
BBUB: 102411712(INMT)
CHX: 102186084
OAS: 101123289
SSC: 100512997(INMT)
BACU: 103019292
LVE: 103070876
OOR: 101284322(INMT)
DLE: 111180005(INMT)
PCAD: 102980842(INMT)
ECB: 100055070
EPZ: 103541247(INMT)
EAI: 106830978 106831065(INMT)
MNA: 107544372(INMT)
MJV: 108403655(INMT)
LAV: 100671921(INMT)
TMU: 101350596
OAA: 100081148(INMT)
ACS: 100553677
XTR: 100491548 496676(nnmt) 548447 594924(inmt)
SKO: 100367711
CBR: CBG21119
MYI: 110462853
ADF: 107342266
AMIL: 114946916
PDAM: 113682356
 » show all
Reference
1  [PMID:3949799]
  Authors
Ansher SS, Jakoby WB.
  Title
Amine N-methyltransferases from rabbit liver.
  Journal
J Biol Chem 261:3996-4001 (1986)
Reference
2  [PMID:3377829]
  Authors
Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB.
  Title
Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
  Journal
Biochem Pharmacol 37:1673-7 (1988)
DOI:10.1016/0006-2952(88)90426-1
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.49
IUBMB Enzyme Nomenclature: 2.1.1.49
ExPASy - ENZYME nomenclature database: 2.1.1.49
BRENDA, the Enzyme Database: 2.1.1.49
CAS: 51377-47-0 111694-10-1

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