KEGG   ENZYME: 2.1.1.5Help
Entry
EC 2.1.1.5                  Enzyme                                 

Name
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
trimethylammonioacetate:L-homocysteine S-methyltransferase
Reaction(IUBMB)
betaine + L-homocysteine = dimethylglycine + L-methionine [RN:R02821]
Reaction(KEGG)
Substrate
betaine [CPD:C00719];
L-homocysteine [CPD:C00155]
Product
dimethylglycine [CPD:C01026];
L-methionine [CPD:C00073]
History
EC 2.1.1.5 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K00544  betaine-homocysteine S-methyltransferase
Genes
HSA: 635(BHMT)
PTR: 461786(BHMT)
PPS: 100985336(BHMT)
GGO: 101138811(BHMT)
PON: 100174207(BHMT)
NLE: 100588814(BHMT)
MCC: 714363(BHMT)
MCF: 102117049(BHMT)
CSAB: 103223581(BHMT)
RRO: 104662970(BHMT)
RBB: 108528900(BHMT)
CJC: 100393375(BHMT)
SBQ: 101049322(BHMT)
MMU: 12116(Bhmt)
RNO: 81508(Bhmt)
CGE: 100754488(Bhmt)
NGI: 103750287(Bhmt)
HGL: 101723121(Bhmt)
CCAN: 109675223(Bhmt)
OCU: 100339955(BHMT)
TUP: 102489167(BHMT)
CFA: 479171(BHMT)
AML: 100465664(BHMT)
UMR: 103681460(BHMT)
ORO: 101373012(BHMT)
FCA: 101085179(BHMT)
PTG: 102955687(BHMT)
AJU: 106974816
BTA: 497025(BHMT)
BOM: 102286920(BHMT)
BIU: 109564665(BHMT)
PHD: 102328254(BHMT)
CHX: 102175297(BHMT)
OAS: 101113853(BHMT)
SSC: 397371(BHMT)
CFR: 102523171(BHMT)
CDK: 105084827(BHMT)
BACU: 103000437(BHMT)
LVE: 103081575(BHMT)
OOR: 101282223(BHMT)
ECB: 100073265
EPZ: 103548663(BHMT)
EAI: 106841179(BHMT)
MYB: 102252728(BHMT)
MYD: 102775016(BHMT)
HAI: 109381916(BHMT)
RSS: 109445646(BHMT)
PALE: 102887754(BHMT)
LAV: 100672133(BHMT)
TMU: 101354749
MDO: 100032615(BHMT)
SHR: 100927569
OAA: 100088080(BHMT)
GGA: 416371(BHMT)
MGP: 100541641
CJO: 107305933
APLA: 101802407(BHMT)
ACYG: 106042084
TGU: 100221623(BHMT)
GFR: 102044419(BHMT)
FAB: 101813460(BHMT)
PHI: 102112767(BHMT)
PMAJ: 107216432
CCAE: 111941401
CCW: 104695711
FPG: 101910450(BHMT)
FCH: 102048321(BHMT)
CLV: 102097034
EGZ: 104124900
AAM: 106490831 106499347
ASN: 102378363
AMJ: 102561209(BHMT)
PSS: 102445649
CMY: 102947612(BHMT)
CPIC: 101937801(BHMT)
ACS: 100558455
PVT: 110073962(BHMT)
PBI: 103049200
GJA: 107117367
XLA: 495275(bhmt.L)
XTR: 496651(bhmt)
NPR: 108799975
DRE: 322228(bhmt)
SRX: 107717756 107724714(bhmt)
SANH: 107679462
SGH: 107574103 107577077 107581092
CCAR: 109046108 109089479
IPU: 108279028
AMEX: 103034807
TRU: 101061373 101062063
TNG: GSTEN00030962G001 GSTEN00036228G001
LCO: 104921205 104921289 104930138 104930139 104936284
NCC: 104943386 104943387 104948669 104948670 104966862
MZE: 101464577 101482601 112435685
OLA: 101157623 101175580
XMA: 102218191 102225771 102226035
PRET: 103470080 103470081 103473309
NFU: 107374849 107394162
KMR: 108233717 108233718 108251296
CSEM: 103390007 103397629
LCF: 108878770 108882050 108882056 108895445
SDU: 111229230 111237735 111237759 111239026
HCQ: 109517690 109527101
BPEC: 110156680 110156723 110157444 110172084 110172085
MALB: 109953000 109956508
SASA: 100194600(bhmt) 106568115
OTW: 112220278 112230819
ELS: 105015174
SFM: 108925116 108925117(bhmt)
LCM: 102351553(BHMT)
CMK: 103177766(bhmt)
BFO: BRAFLDRAFT_119742 BRAFLDRAFT_123950 BRAFLDRAFT_234263 BRAFLDRAFT_248283 BRAFLDRAFT_268352 BRAFLDRAFT_60534 BRAFLDRAFT_78594 BRAFLDRAFT_88433 BRAFLDRAFT_88434 BRAFLDRAFT_88435 BRAFLDRAFT_90102 BRAFLDRAFT_90330
CIN: 100180493 100181849 100182838 108950018
SPU: 575553 588895
APLC: 110974267 110984668 110987105 110988857
SKO: 100372758 100372908 100374951 100376137 100376292 100378429 100378580 100378727 102807376
ISC: IscW_ISCW001818
LGI: LOTGIDRAFT_183387 LOTGIDRAFT_230320
CRG: 105329125
MYI: 110455538
LAK: 106166449 106167822 106171079 106171080 106171100 106178981
NVE: NEMVE_v1g236455
EPA: 110231416 110238130 110238131 110238132 110238135 110240957 110240959 110240960 110242935 110246242
ADF: 107340042 107340771 107342964
HMG: 100206048
TAD: TRIADDRAFT_63716
ACAN: ACA1_155280
FPH: Fphi_0698
FPT: BZ13_1329
FPI: BF30_905
FPM: LA56_1471
FPX: KU46_649
FPZ: LA55_102
FPJ: LA02_579
FRT: F7308_0118
FNA: OOM_0106
FRF: LO80_06845
FHA: CDV26_01030
FRX: F7310_00640
SPIU: SPICUR_03835
CSA: Csal_0065
DRT: Dret_2255
THW: BMG03_09465
PUB: SAR11_1173(bhmT)
APC: HIMB59_00001060 HIMB59_00005120 HIMB59_00005130
APM: HIMB5_00004530
BBEV: BBEV_2151(yitJ-1)
OIH: OB0691
HHD: HBHAL_1691
HMN: HM131_17460
VIR: X953_04635
VHL: BME96_03820
VIG: BKP57_05720
VIL: CFK37_04880
VNE: CFK40_05435
VPN: A21D_02277
LAO: AOX59_16950
SJE: AAV35_009460
BSE: Bsel_2622
SHV: AAT16_06155
PMAR: B0X71_09835
PSAI: C3B54_11833
BRX: BH708_15645
BRV: CFK39_10470
BRZ: CFK38_00255
BSAU: DWV08_16395
SERJ: SGUI_2075
BLY: A2T55_13075
BLIN: BLSMQ_2928
DCO: SAMEA4475696_1438(metH_1)
FSI: Flexsi_0945
 » show all
Taxonomy
Reference
1  [PMID:14456704]
  Authors
KLEE WA, RICHARDS HH, CANTONI GL.
  Title
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
  Journal
Biochim Biophys Acta 54:157-64 (1961)
DOI:10.1016/0006-3002(61)90948-9
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.5
IUBMB Enzyme Nomenclature: 2.1.1.5
ExPASy - ENZYME nomenclature database: 2.1.1.5
BRENDA, the Enzyme Database: 2.1.1.5
CAS: 9029-78-1

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (21198)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (257)   
   KEGG MGENES (9807)   
   RefGene (11079)   
   EGENES (54)   
Protein sequence (295)   
   UniProt (64)   
   SWISS-PROT (9)   
   RefSeq(pep) (207)   
   PDBSTR (12)   
   PMD (3)   
DNA sequence (432)   
   RefSeq(nuc) (350)   
   GenBank (42)   
   EMBL (40)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (1)   
   PROSITE(DOC) (1)   
All databases (21944)   

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