KEGG   ENZYME: 2.1.1.5Help
Entry
EC 2.1.1.5                  Enzyme                                 

Name
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
trimethylammonioacetate:L-homocysteine S-methyltransferase
Reaction(IUBMB)
betaine + L-homocysteine = dimethylglycine + L-methionine [RN:R02821]
Reaction(KEGG)
Substrate
betaine [CPD:C00719];
L-homocysteine [CPD:C00155]
Product
dimethylglycine [CPD:C01026];
L-methionine [CPD:C00073]
History
EC 2.1.1.5 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K00544  betaine-homocysteine S-methyltransferase
Genes
HSA: 635(BHMT)
PTR: 461786(BHMT)
PPS: 100985336(BHMT)
GGO: 101138811(BHMT)
PON: 100174207(BHMT)
NLE: 100588814(BHMT)
MCC: 714363(BHMT)
MCF: 102117049(BHMT)
CSAB: 103223581(BHMT)
RRO: 104662970(BHMT)
RBB: 108528900(BHMT)
CJC: 100393375(BHMT)
SBQ: 101049322(BHMT)
MMU: 12116(Bhmt)
MCAL: 110307549(Bhmt)
MPAH: 110328978(Bhmt)
RNO: 81508(Bhmt)
MUN: 110539650
CGE: 100754488(Bhmt)
NGI: 103750287(Bhmt)
HGL: 101723121(Bhmt)
CCAN: 109675223(Bhmt)
OCU: 100339955(BHMT)
TUP: 102489167(BHMT)
CFA: 479171(BHMT)
VVP: 112919588(BHMT)
AML: 100465664(BHMT)
UMR: 103681460(BHMT)
UAH: 113255170(BHMT)
ORO: 101373012(BHMT)
FCA: 101085179(BHMT)
PTG: 102955687(BHMT)
PPAD: 109274945(BHMT)
AJU: 106974816(BHMT)
BTA: 497025(BHMT)
BOM: 102286920(BHMT)
BIU: 109564665(BHMT)
BBUB: 102394345
CHX: 102175297(BHMT)
OAS: 101113853(BHMT)
SSC: 397371(BHMT)
CFR: 102523171(BHMT)
CDK: 105084827(BHMT)
BACU: 103000437(BHMT)
LVE: 103081575(BHMT)
OOR: 101282223(BHMT)
DLE: 111184957(BHMT)
PCAD: 102991634
ECB: 100073265
EPZ: 103548663(BHMT)
EAI: 106841179(BHMT)
MYB: 102252728(BHMT)
MYD: 102775016(BHMT)
MNA: 107535044
HAI: 109381916(BHMT)
DRO: 112307473(BHMT)
PALE: 102887754(BHMT)
RAY: 107497234(BHMT)
MJV: 108387740(BHMT)
LAV: 100672133(BHMT)
TMU: 101354749
MDO: 100032615(BHMT)
SHR: 100927569
PCW: 110216636
OAA: 100088080
GGA: 416371(BHMT)
MGP: 100541641
CJO: 107305933
NMEL: 110389382
APLA: 101802407
ACYG: 106042084
TGU: 100221623
LSR: 110470994
SCAN: 103819545
GFR: 102044419(BHMT)
FAB: 101813460(BHMT)
PHI: 102112767(BHMT)
PMAJ: 107216432
CCAE: 111941401
CCW: 104695711
ETL: 114056915
FPG: 101910450(BHMT)
FCH: 102048321
CLV: 102097034
EGZ: 104124900
ACUN: 113489762
PADL: 103919765
ASN: 102378363
AMJ: 102561209(BHMT)
PSS: 102445649
CMY: 102947612(BHMT)
CPIC: 101937801(BHMT)
ACS: 100558455
PVT: 110073962(BHMT)
PBI: 103049200
PMUR: 107287879
TSR: 106544491
PMUA: 114606168
GJA: 107117367
XLA: 495275(bhmt.L)
XTR: 496651(bhmt)
NPR: 108799975
DRE: 322228(bhmt)
SRX: 107717756 107724714(bhmt)
SANH: 107679462
IPU: 108279028
PHYP: 113535813
AMEX: 103034807
EEE: 113573779
SASA: 100194600(bhmt) 106568115
ELS: 105015174
SFM: 108925116 108925117(bhmt)
PKI: 111849814(bhmt) 111849880
LCM: 102351553(BHMT)
CMK: 103177766(bhmt)
RTP: 109930797(bhmt)
CSCU: 111619880
PTEP: 107451377
CRG: 105329125
MYI: 110455538
HMG: 100206048
FPH: Fphi_0698
FPT: BZ13_1329
FPI: BF30_905
FPM: LA56_1471
FPX: KU46_649
FPZ: LA55_102
FPJ: LA02_579
FNA: OOM_0106
CSA: Csal_0065
DRT: Dret_2255
PUB: SAR11_1173(bhmT)
BBEV: BBEV_2151(yitJ-1)
OIH: OB0691
HLI: HLI_07355
BSE: Bsel_2622
SERJ: SGUI_2075
BLIN: BLSMQ_2928
DCO: SAMEA4475696_1438(metH_1)
 » show all
Taxonomy
Reference
1  [PMID:14456704]
  Authors
KLEE WA, RICHARDS HH, CANTONI GL.
  Title
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
  Journal
Biochim Biophys Acta 54:157-64 (1961)
DOI:10.1016/0006-3002(61)90948-9
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.5
IUBMB Enzyme Nomenclature: 2.1.1.5
ExPASy - ENZYME nomenclature database: 2.1.1.5
BRENDA, the Enzyme Database: 2.1.1.5
CAS: 9029-78-1

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