KEGG   ENZYME: 2.1.1.5
Entry
EC 2.1.1.5                  Enzyme                                 
Name
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
trimethylammonioacetate:L-homocysteine S-methyltransferase
Reaction(IUBMB)
betaine + L-homocysteine = dimethylglycine + L-methionine [RN:R02821]
Reaction(KEGG)
R02821
Substrate
betaine [CPD:C00719];
L-homocysteine [CPD:C00155]
Product
dimethylglycine [CPD:C01026];
L-methionine [CPD:C00073]
History
EC 2.1.1.5 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00270  Cysteine and methionine metabolism
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00544  betaine-homocysteine S-methyltransferase
Genes
HSA635(BHMT)
PTR461786(BHMT)
PPS100985336(BHMT)
GGO101138811(BHMT)
PON100174207(BHMT)
PPYG129037511(BHMT)
NLE100588814(BHMT)
HMH116471070(BHMT)
SSYN129493055(BHMT)
MCC714363(BHMT)
MCF102117049(BHMT)
MTHB126957590
MNI105475095(BHMT)
CSAB103223581(BHMT)
CATY105599167(BHMT)
PANU101022670(BHMT)
TGE112626272(BHMT)
MLEU105548271(BHMT)
RRO104662970(BHMT)
RBB108528900(BHMT)
TFN117065310(BHMT)
PTEH111544428(BHMT)
CANG105524090(BHMT)
CJC100393375(BHMT)
SBQ101049322(BHMT)
CIMI108303778(BHMT)
ANAN105723868(BHMT)
CSYR103250081(BHMT)
MMUR105872623(BHMT)
LCAT123648430(BHMT)
PCOQ105826595(BHMT)
OGA100945871(BHMT)
MMU12116(Bhmt)
MCAL110307549(Bhmt)
MPAH110328978(Bhmt)
RNO81508(Bhmt)
MCOC116083552(Bhmt)
ANU117700497(Bhmt) 117717310
ASYL127666925(Bhmt)
MUN110539650
CGE100754488(Bhmt)
MAUA101832592(Bhmt)
PROB127221074(Bhmt)
PLEU114694686(Bhmt)
MORG121455833(Bhmt)
MFOT126508497
AAMP119810203(Bhmt)
NGI103750287(Bhmt)
HGL101723121(Bhmt)
CPOC100724631(Bhmt)
CCAN109675223(Bhmt)
DORD105985348(Bhmt)
DSP122117199(Bhmt)
DMER138832935 138837136
PLOP125339895
NCAR124986895
MMMA107152310(Bhmt)
ITI101972215
OCU100339955
OPI101519034
TUP102489167(BHMT)
GVR103597321(BHMT)
CFA479171(BHMT)
CLUD112653426(BHMT)
VVP112919588(BHMT)
VLG121489537(BHMT)
NPO129521084(BHMT)
AML100465664(BHMT)
UMR103681460(BHMT)
UAH113255170(BHMT)
UAR123791536(BHMT)
ELK111148342
LLV125100501
MPUF101682838
MNP132028758(BHMT)
MLK131832393(BHMT)
NVS122901114(BHMT)
ORO101373012(BHMT)
EJU114217614(BHMT)
ZCA113929554(BHMT)
MLX118017139(BHMT)
NSU110589329(BHMT)
LWW102732753(BHMT)
FCA101085179(BHMT)
PYU121014017(BHMT)
PCOO112860987
PBG122490207
PVIV125161206
LRUF124504614
LGF123607363(BHMT)
AJU106974816
PTG102955687(BHMT)
PPAD109274945(BHMT)
PUC125934939
PLEZ122222034(BHMT)
HHV120242011(BHMT)
BTA497025(BHMT)
BOM102286920
BIU109564665(BHMT)
BBUB102394345
BBIS104984714(BHMT)
CHX102175297
OAS101113853(BHMT)
BTAX128054421
CSUM138072793
ODA120852576(BHMT)
CCAD122443008(BHMT)
MREE136171955
OVR110139733(BHMT)
MBEZ129563603
SSC397371(BHMT)
CFR102523171(BHMT)
CBAI105064349(BHMT)
CDK105084827(BHMT)
VPC102525828(BHMT)
BACU103000437(BHMT)
BMUS118892398(BHMT)
LVE103081575(BHMT)
OOR101282223(BHMT)
LALB132518124(BHMT)
GMF115845143
DLE111184957(BHMT)
PCAD102991634
PSIU116750387(BHMT)
PPHC136120057(BHMT)
NASI112406757(BHMT)
ECB100073265
EPZ103548663
EAI106841179(BHMT)
MYB102252728(BHMT)
MYD102775016(BHMT)
MMYO118656687(BHMT)
MLF102425902(BHMT)
MDT132233488(BHMT)
MYUM139008705
PKL118703445(BHMT)
EFUS103305221(BHMT)
MNA107535044
DRO112307473(BHMT)
SHON118977292(BHMT)
AJM119035984
PDIC114510404(BHMT)
PHAS123824717(BHMT)
MMF118641671(BHMT)
PPAM129074639(BHMT)
HAI109381916(BHMT)
RFQ117025006(BHMT)
PALE102887754(BHMT)
PGIG120612469(BHMT)
PVP105304644(BHMT)
RAY107497234(BHMT)
MJV108387740(BHMT)
TOD119260224(BHMT)
SARA101541457(BHMT)
SFUM130021834
SETR126001877(BHMT)
LAV100672133(BHMT)
TMU101354749
ETF101642241(BHMT)
DNM101442098
MDO100032615(BHMT)
GAS123236818
SHR100927569(BHMT)
AFZ127558468
PCW110216636
TVP118852971(BHMT)
PBRV138167435
MLAO141497999
OAA100088080 100088098(BHMT2)
TACU119944560 119944759
GGA416371(BHMT)
PCOC116239911
MGP100541641
CJO107305933
TPAI128074393
LMUT125687327
NMEL110389382
APLA101802407
ACYG106042084
CATA118251473
AFUL116500626
TGU100221623
LSR110470994
SCAN103819545
PMOA120502442
OTC121341255
PRUF121355361
ATRC139589136
GFR102044419(BHMT)
FAB101813460(BHMT)
OMA130265578
PHI102112767
PMAJ107216432
CCAE111941401
CCW104695711
CBRC103622046
ACOE138103078
ETL114056915
ZAB102071668
ZLE135459727
ACHL103810908
SVG106856212
MMEA130572275
HRT120765162
SATI136374647
CCIC134056554
FPG101910450(BHMT)
FCH102048321
CCRI104169315
NNT104411470
SHAB115601220
ACUN113489762
TALA104357116
ACHC115336616
HALD104311516
HLE104841296
AGEN126035668
HHAR128136644
GCL127027354 127028691
CSTI104559023
LDI104348421
MNB103767887
DPUB104309462
PPUS135193086
AVIT104268516
BRHI104497298
EGZ104124900
NNI104011959 104017633
PCRI104037008
PCAO104052704
PADL103919765
AFOR103899795
FGA104077850
GSTE104262804
CBOY140650822
CLV102097034
CNIC136001492
MUI104540707
PGUU104458762
PLET104615204
EHS104509696
CMAC104481766
CUCA104064002
TEO104380260
BREG104634490
OHA104330961
ACAR104518556
CPEA104395693
CVF104285791
RTD128902458
CRID134508626
AAM106490831 106499347
AROW112967357
NPD112945144
TGT104581206
DNE112987027
SCAM104152993
ASN102378363
AMJ102561209(BHMT)
CPOO109307998
GGN109297738
PSS102445649
CMY102947612
CCAY125636505
DCC119855822
CPIC101937801
TST117878734
CABI116823758
MRV120408209
ACS100558455
ASAO132767046
PVT110073962(BHMT)
SUND121923668
PBI103049200
PMUR107287879
CTIG120312302
TSR106544491
PGUT117679272
PCAE139313296
APRI131192943
PTEX113447452
NSS113413944 113419350
VKO123031562
PMUA114606168
PRAF128423192
ZVI118076698(BHMT)
HCG128344708
GJA107117367
STOW125436280
EMC129334292
XLA495275(bhmt.L)
XTR496651(bhmt)
NPR108799975
RTEM120929341
ACAT141134188
BBUF120992415
BGAR122924738
DTC141097140
PWL138284475
MUO115463048
GSH117353538
DRE322228(bhmt)
SRX107717756 107724714(bhmt)
SANH107679462
SGH107574103
CCAR109046108(bhmt) 122141253
CAUA113080755 113097702
CGIB127942096 127986306
PTET122341028(bhmt)
LROH127162125(bhmt)
GRF141292219(bhmt)
OMC131528427(bhmt)
PPRM120461919(bhmt)
RKG130088056(bhmt)
MAMB125252262(bhmt)
CIDE127504046
CERY137012162(bhmt)
MASI127430858
TROS130550720(bhmt)
TDW130407734(bhmt)
MANU129423064(bhmt)
PDAB135721387(bhmt)
IPU108279028(bhmt)
IFU128622897(bhmt)
PHYP113535813
SMEO124397867(bhmt)
TFD113646449(bhmt)
TVC132860088(bhmt)
CGAR128507187(bhmt)
NGRA132895148(bhmt)
TRN134330404(bhmt)
AMEX103034807(bhmt)
CMAO118820406(bhmt)
EEE113573779
CHAR105901160 105901214 105902436(bhmt) 105910603
SPIL134088344 134088775 134088777 134101044(bhmt)
TRU101061373 101062063
TFS130517451(bhmt) 130526444
TNGGSTEN00030962G001
LCO104921205 104921289 104930138 104930139 104936284
NCC104943386 104943387 104948669 104948670 104966862
TBEN117472348 117475958 117476489(bhmt)
CGOB115013331 115013368 115013615 115016357
PGEO117452088 117455756(bhmt)
GACU117536708 117560599 117560604 117561495
EMAC134868888(bhmt) 134873351 134873820 134874286
ELY117251874 117251875 117252237 117252925 117252926 117269200
EFO125890425 125890426 125890449 125890450 125906136
PLEP121944080 121944246 121944247 121944389
SLUC116054167 116054168 116056791 116062994(bhmt)
ECRA117945057 117945058 117945219 117959558(bhmt)
ESP116689207 116689257
PFLV114555694 114555876 114555939 114570759
GAT120830956 120830957 120831287 120832005(bhmt)
PPUG119224706 119224707 119225361 119225362 119226903(bhmt)
AFB129100666 129100667 129100923 129100924 129102188
CLUM117735983 117736261 117736815 117736816 117740696 117740910(bhmt)
PSWI130196706 130197168 130197169 130205406(bhmt)
CANA137784199(bhmt) 137805078 137805080 137805226 137805389
CVE137866901 137866902 137866973 137867003 137868758 137869252
MSAM119891844 119914971(bhmt)
SCHU122865754 122876422 122876937 122876938
CUD121509995 121510073 121510074 121510092 121525687(bhmt)
SPUL138601888 138610185 138610304 138610395 138610588
LMIX132974167 132974168 132974539 132974540 132992692(bhmt)
ALAT119018856 119018903 119018904 119019260 119019508 119030143
ASTR137592480 137592725 137592798 137608241
MZE101464577 101482601 112435685
ONL100704302 100705166 100705436
OAU116315584 116328388 116328389
OLA101157623 101175580
OML112148056 112162826(bhmt)
CSAI133450647 133450648 133454611(bhmt)
XMA102218191 102225771 102226035
XCO114149906 114154707 114154708
XHE116724267 116730429 116730431
PRET103470080 103470081 103473309
PFOR103135835 103141748
PLAI106937104 106956825
PMEI106916212 106923054
GAF122819377(bhmt) 122827328 122827332
PPRL129365809 129374187(bhmt)
CVG107092421 107092484 107093785
CTUL119788268(bhmt) 119798561 119798562
GMU124873094(bhmt) 124877131
NFU107374849 107394162
KMR108233717 108233718 108251296(bhmt)
ALIM106513660 106532974
NWH119413898
AOCE111564721 111564722 111570352 111581621
EJA138191795 138191980 138207512(bhmt) 138215909
BFRE138622957(bhmt) 138626245 138626246 138627213
MCEP124996948(bhmT) 125012487 125012488 125012755 125012756
CSEM103390007 103397629
POV109625962 109637078 109637079 109638087
SSEN122758689(bhmt) 122769031 122769454
SSOE131446761(bhmt) 131463421 131463502
HHIP117767260 117768517 117768519 117771585(bhmt)
HSP118098097 118114836 118114895 118114896
PPLT128424855 128437929 128438014 128438016
SMAU118301462(bhmt) 118313322 118314207 118314208
LCF108878770 108882050 108882056 108895445(bhmt)
SDU111229230 111237735 111237759 111239026
SLAL111651687 111651689 111660294 111666825
XGL120805803 120806477
HCQ109517690 109527101
SSCV125979297(bhmt) 125994694
SBIA133499786 133515234
PEE133399939 133413362(bhmt)
PTAO133475179 133489844(bhmt)
BPEC110156680 110156723 110157444 110172084 110172085
ENY140346518 140346520 140347164 140347221 140367764(bhmt)
MALB109953000 109956508
BSPL114862603 114867454(bhmt)
SJO128364714 128364715 128364815 128365203 128380740
SSCO133978839 133978840 133979669 133979671 133995006(bhmt)
GMH115541269 115545184 115545185 115546034
SASA100194600(bhmt) 106568115
STRU115159735 115203928
OTW112220278(bhmt) 112230819
OMY110509664 110523446(bhmt)
OGO124007416 124049093
ONE115101012 115121040
OKI109868318 109874056
OKE118371634 118385459
OMM135518098 135544626
OCLA139387782 139408525
SALP111961763 111963903
SNH120021263 120025679
CCLU121541555 121582649
ELS105015174
OEP134011943 134038755(bhmt)
SFM108925116 108925117(bhmt)
PKI111849814(bhmt) 111849880
AANG118213304 118213305(bhmt) 118237452
AROT135233340 135239250 135239251(bhmt)
CCOG133140891 133141899 133141995
LOC102689652
PSPA121305143 121313674
ARUT117403613 117974146
PSEX120532416(bhmt)
LCM102351553(BHMT)
CMK103177766(bhmt)
RTP109930797(bhmt)
CPLA122558390(bhmt)
HOC132822390(bhmt)
LERI129694867 129714267
HAKA140729002(bhmt)
PMRN116942187
LRJ133343910 133343913
BFO118403599 118403625 118403740 118403835 118408941 118409375 118412861 118419165 118419166 118420119 118422786 118423158 118423159
BBEL109462372 109463244 109464847 109467561 109472834 109474178 109474209 109474210 109476287 109481064
CIN100180493 100181849 100182838 113474336
SCLV120326246 120327870 120328505 120328506 120328890
SPU100891161 105438577 105447246 115918144 115918913 115928328 115929946 575553 579857 580174 582813 588895 589758 752628
LPIC129258483 129258484 129258534 129259077 129259157 129259605 129262595 129264145 129265678
AJJ139958528 139962507 139962965 139971535 139971536 139971538 139971539 139971607 139971611 139979195
APLC110974267 110984631 110984637 110984652 110984655 110984668 110984669 110984679 110986934 110987105 110988857 110990180
ARUN117291614 117291624 117295761 117296186 117296591 117296670 117297075 117300418
AAMU139941757 139942123 139943076 139943351 139943362 139946702 139946703 139946735
AFIL140152622 140156315 140156934 140159233 140160598 140163633 140166003 140166390
AJC117103427 117116060 117122225
SKO100371248 100372758 100372908 100374951 100376137 100376292 100376443 100376597 100378429 100378580 100378727 102807376
PFLL139121850 139133372 139133941 139133968 139133978 139133986 139134005 139140876 139140901 139141733 139142385 139142397 139142398 139142400 139142401 139142402 139142403 139142412 139142414 139142415 139142417 139142418
SGRE126354127
IEL124154290
HAMR139687557
PVM113808272 113817434 113819630
PJA122245301 122247003 122258389 122266441
PCHN125033259 125033278 125035210 125035256
PMOO119577942 119583518 119583532
HAME121878891 121878895
PCLA123771683
CQD128696652
PTRU123504391 123504392 123504421 123512443
ESN126997661 126997662 127008696
MNZ135208776 135208777 135213177
MRJ136826229 136846065 136846068
PORN139749753 139760460
HAZT108678493
EAF111700817 111700974 111708867
LSM121129618
PPOI119090929 119094136 119096867
ISC8023777
DSV119442634
RSAN119387357 119387358
RMP119188312
CSCU111619880
CVS136990240
PTEP107451377
ABRU129961808
UDV129225264
SDM118188532 118195838
LPOL106462891 106462894 106462895
LGILOTGIDRAFT_183387 LOTGIDRAFT_217867 LOTGIDRAFT_230320 LOTGIDRAFT_233748
PVUL126809610 126811534 126812388 126812389 126812390 126827744 130010354 130010432 130013622
PCAN112572659
LSAX138960908 138965360
BGT106073434 106073435
HRF124129484 124137148 124138282 124138283 124138284 124140307 124140311 124140312 124146516 124146517 124146524
HRJ124262605 124262606 124262607 124262608 124262609 124269213 124269214 124280593 124289090 124291430 124291446
HASI137286727 137286733 137286921 137287159 137287244 137287245 137287376 137287378 137287762 137296959 137296960 137296962 137296963 137296965 137296966
HCRA139444851 139445633 139474066 139474383 139474414 139474940 139474942 139475024 139475252 139475572
CRG105339575
CANU128159878 128161362 128184450 128185728
CVN111102594 111108276 111109969
OED125674091 125674093 125676132 125676585 125677062 130048310 130048311
MYI110455538 110456381 110456382 110456384 110456469 110458153 110464929 110464943 110467328
PMAX117326857 117326858 117326859 117327192 117327193 117327194 117327227 117328542 117330294 117331264 117331595
AIRR138305195 138335688 138335743 138336061 138336311 138336814
MCAF127736458
MMER123527072 123528071 123536698 123546866 123546873 123548659 123548660 123550078 123551338 123551339 123551349 123552786 128556290
RPHI132734918 132738754 132738770 132746720 132747124 132747125 132749131 132749132
DPOL127841289 127850279
MAEA128216893 128218132 128218565 128236706 128237814 128238828 128239155 128239236
OBI106875610 106880067
OSN115222737 115222981 115223003
LJP135468805 135472210 135479334 135481780 135481872
LAK106156503 106166038 106166449 106167822 106171079 106171080 106171100 106178981 106179201
LLON135482447 135484100 135484156 135485181 135497945 135498145 135498158
NVE5519847 5521086
EPA110231416 110238130 110238131 110238132 110240957 110240959 110240960 110242935 110246242
ATEN116294619 116295943 116297504 116297506 116297515 116301137
ADF107340042 107342964
AMIL114950037 114953867 114960594 114974172
MCAZ138038991 138049022 138049023
MFOO137984993 137985217 137992654
PDAM113672660 113673312 113674473 113682319 113686957
SPIS111324403 111336507 111338100 111344161
DGT114518175 114533873 114540583
XEN124453110 124455543
HMG100206048
HSY130640717 130640969 130641098 130645044 130649193
RES135687789 135688357 135688409
TADTRIADDRAFT_63716 TRIADDRAFT_63717
AQU100638323 100639967 100640174 100640299 105315720
ACANACA1_155280
PSKYA6B44_09920
FPHFphi_0698
FPTBZ13_1329
FPIBF30_905
FPMLA56_1471
FPXKU46_649
FPZLA55_102
FPJLA02_579
FRTF7308_0118
FRFLO80_06845
FHACDV26_01030
FRXF7310_00640
FRCKX01_643 KX01_645
FADCDH04_09075
FMIF0R74_09025 F0R74_09035
FSRKQR59_00590
FRLFIP56_00595
SPIUSPICUR_03835
SROSBBH56_03220
CSACsal_0065
CCAGSR908_07635
HHAOQWG60_02820
SUTRL0B52_00870
OCDFHY55_16660
PLCGRVY76_00055
THWBMG03_09465
TECAKL02_008645
PUBSAR11_1173(bhmT)
APCHIMB59_00001060 HIMB59_00005120 HIMB59_00005130
APMHIMB5_00004530
DRTDret_2255
DALKDSCA_49870
MICAP0L94_16250
FSIFlexsi_0945
BSHILGQ02_01385
OIHOB0691
OJDNP439_03915
OONNP440_03885
HHDHBHAL_1691
HMNHM131_17460
HLIHLI_07355
HNZP9989_03155
HSANMUN89_12680
HSHIMUO14_02735
HAMYMUO15_00845
VIRX953_04635
VHLBME96_03820
VIGBKP57_05720
VILCFK37_04880
VNECFK40_05435
VPNA21D_02277
VPTKBP50_17210
VIKKFZ58_07585
LAOAOX59_16950
SJEAAV35_009460
SAPLU0355_11135
POFGS400_01695
PCHUQNI29_12900
PONAIMZ31_11310
BBEVBBEV_2151(yitJ-1)
BSEBsel_2622
AHALFTX54_001395
PHJLC071_01415
SHVAAT16_06155
SBAHRQP18_09875
PMARB0X71_09835
SPAEE2C16_15420
ERZER308_05595
PSAIC3B54_11833
BRXBH708_15645
BRVCFK39_10470
BRZCFK38_00255
BSAUDWV08_16395
HMMR3I40_01245
SERJSGUI_2075
BLYA2T55_13075
BLINBLSMQ_2928
BCAUI6G59_17580
BSPOL1F31_13415
BREBPGC08_14585
BREJLJ362_12360
BKRAAFP32_12220
DCOSAMEA4475696_1438(metH_1)
TTRTter_2133
KBSEPA93_23460
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Reference
1  [PMID:14456704]
  Authors
KLEE WA, RICHARDS HH, CANTONI GL.
  Title
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
  Journal
Biochim Biophys Acta 54:157-64 (1961)
DOI:10.1016/0006-3002(61)90948-9
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.5
IUBMB Enzyme Nomenclature: 2.1.1.5
ExPASy - ENZYME nomenclature database: 2.1.1.5
BRENDA, the Enzyme Database: 2.1.1.5
CAS: 9029-78-1

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