| Entry |
|
| Name |
mRNA (guanine-N7)-methyltransferase;
RNMT (gene name);
ABD1 (gene name);
messenger ribonucleate guanine 7-methyltransferase;
guanine-7-methyltransferase;
messenger RNA guanine 7-methyltransferase;
S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase
|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
| Sysname |
S-adenosyl-L-methionine:mRNA (guanine-N7)-methyltransferase
|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [RN: R03805]
|
| Reaction(KEGG) |
|
| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
5'-(5'-triphosphoguanosine)-[mRNA] [CPD: C02031]
|
| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [CPD: C02339]
|
| Comment |
The terminal N7-methylguanosine facilitates gene expression in eukaryotic cells and is recognized by cap-binding proteins.
|
| History |
EC 2.1.1.56 created 1981
|
| Orthology |
| K00565 | mRNA (guanine-N7-)-methyltransferase |
| K25991 | Poxviridae mRNA-capping enzyme catalytic subunit |
| K26429 | Asfivirus mRNA-capping enzyme |
|
| Genes |
| AAMP: | 119813978(Rnmt) 119815075 119823563 |
| MMMA: | 107154471 107159446(Rnmt) |
| CLUD: | 112644114(RNMT) 112657219 112664489 |
| OAS: | 101110469(RNMT) 114118402 |
| CCAD: | 122425464(RNMT) 122431768 |
| TOD: | 119242851 119243235(RNMT) 119243237 119243961 119258439 |
| SETR: | 126003734(RNMT) 126008940 |
| PBRV: | 138149733 138170341(RNMT) |
| MUO: | 115457172(RNMT) 115476258 |
| CCAR: | 109084195 109103819 |
| CAUA: | 113068289(rnmt) 113119176 |
| CGIB: | 127935343 127979709 |
| PPRM: | 120485401 120485452(rnmt) |
| MASI: | 127420734 127424845 |
| PPRL: | 129354175 129356565 |
| DSI: | Dsimw501_GD23987(Dsim_GD23987) |
| CQU: | CpipJ_CPIJ004742 CpipJ_CPIJ005791 CpipJ_CPIJ013420 CpipJ_CPIJ019098 |
| CPII: | 120425412 120425676 |
| CFEL: | 113371195 113372576 113373107 |
| AFRA: | 136031728 136038562 |
| HAZT: | 108664586 108665073 |
| CEL: | CELE_C25A1.3(tag-72) |
| CBR: | CBG_12234(Cbr-tag-72) |
| DPOL: | 127844474 127846413 |
| ALY: | 9312198 9321458 9327675 |
| CSAT: | 104711776 104746481 104781065 104785621 104791473 109124609 |
| EUS: | EUTSA_v10010496mg EUTSA_v10020966mg |
| BRP: | 103835855 103841160 103869297 |
| BNA: | 106346002 106367837 106377599 106397365 106402517 125587773 125596914 125598492 |
| BOE: | 106292584 106311714 106318246 |
| RSZ: | 108807156 108811797 108857096 130502831 |
| CIC: | CICLE_v10008689mg CICLE_v10031936mg |
| MINC: | 123192182 123201396 |
| GRA: | 105777517 105779979 105783003 |
| GHI: | 107895209 107896314 107915773 107916939 107920058 107951770 |
| GAB: | 108464301 108482375 108487143 |
| HSYR: | 120156091 120159074 120164504 120174579 |
| DZI: | 111275746 111288362 111295493 |
| GMX: | 100779811 100783006 100810904 100817375 |
| GSJ: | 114410311 114415533 114417008 114422432 |
| CCAJ: | 109798039 109813294 109817893 |
| APRC: | 113865180 113873904 |
| MTR: | 11442053 11443469 25495070 |
| TPRA: | 123905135 123909279 123920293 |
| PSAT: | 127082141 127105729 |
| VVO: | 131601748 131622592 131626398 131661313 |
| ADU: | 107460493 107476786 107493214 |
| AIP: | 107605923 107629006 107645346 |
| AHF: | 112696425 112705927 112736759 112754425 112755869 112764124 112788853 |
| LANG: | 109325350 109328308 109352190 |
| PCIN: | 129294678 129296619 129298562 129312963 129315416 |
| QSA: | O6P43_000887 O6P43_004951 O6P43_029840 |
| PMUM: | 103326357 103332295 |
| PAVI: | 110752201 110765505 |
| PDUL: | 117617691 117626508 |
| MDM: | 103423005 103429539 103439480 114819132 |
| MSYL: | 126588807 126616060 126619229 126629139 |
| PXB: | 103934444 103946556 103958422 103958433 |
| CSAV: | 115694707 115706094 |
| MCHA: | 111010246 111010374 |
| CMAX: | 111467776 111480609 |
| CMOS: | 111446362 111449271 |
| CPEP: | 111788570 111801510 |
| MEAN: | 126661159 126664528 |
| MESC: | 110599719 110624004 |
| PALZ: | 118047472 118059862 |
| JRE: | 108993325 109014269 109015563 |
| CILL: | 122282645 122290881 |
| CAVE: | 132175786 132187142 |
| SLY: | 101253413 101256441 101267011 |
| SPEN: | 107003229 107012796 107029339 |
| SOT: | 102580566 102582805 102602590 |
| SSTN: | 125845420 125860562 125871577 |
| SDUL: | 129882407 129894474 129899599 |
| CANN: | 107842586 107851101 107862120 |
| LBB: | 132614730 132630775 132633160 |
| NTA: | 107798810 107803089 107817051 107827391 107830908 107832555 |
| SIND: | 105161296 105174798 105176745 |
| OEU: | 111381019 111393451 111402513 111408352 |
| SSPL: | 121778661 121780976 121785309 121785921 |
| SMIL: | 131007817 131014765 |
| SHIS: | 125211830 125216765 |
| APAN: | 127243997 127253259 |
| ECAD: | 122599414 122603588 |
| CCAV: | 112500824 112501112 |
| DCR: | 108205593 108210678 108225946 |
| CSIN: | 114284597 114294143 114294432 |
| RVL: | 131307182 131307244 131319475 |
| CQI: | 110684348 110693164 110703941 110716632 110716942 110739668 |
| ATRI: | 130817709 130818172 |
| MING: | 122060050 122069266 122088158 122088284 |
| TSS: | 122641143 122651914 122671593 |
| PSOM: | 113285965 113293082 113312003 113319133 113329135 113348713 |
| OSA: | 4330921 4344818(OsJ_26261) |
| BDI: | 100828556 100832725 100845209 |
| ATS: | 109764347 109776134 109777325 |
| TDC: | 119317765 119324728 119328249 119355804 119364947 119365739 |
| TAES: | 123040154 123046063 123049630 123114450 123128290 123138143 123145400 123180667 123185733 |
| LPER: | 127326236 127335668 |
| LRD: | 124664517 124674354 124677714 124688422 124688431 |
| SBI: | 8062919 8069685 8082859 |
| ZMA: | 100193629 100283589 103627789 |
| MFLO: | 136452375 136476391 136493247 136493280 |
| SITA: | 101763425 101776969 |
| PVIR: | 120642493 120677534 120683150 120711593 |
| PHAI: | 112897010 112899827 |
| MUS: | 103978896 103994102 135623840 |
| ZOF: | 121971431 121976228 122041768 122046292 |
| DCT: | 110096007 110097129 110115816 |
| MSIN: | 131221707 131234694 |
| ACAK: | 137938328 137956564 |
| NCOL: | 116245758 116252670 |
| SMO: | SELMODRAFT_158424 SELMODRAFT_424575 SELMODRAFT_84950 SELMODRAFT_96176 |
| GSL: | Gasu_35370 Gasu_57380 |
| CGR: | 2890389(GVI51_K06897) |
| NCS: | NCAS_0H01290(NCAS0H01290) |
| NDI: | NDAI_0F02000(NDAI0F02000) |
| TPF: | TPHA_0N01140(TPHA0N01140) |
| TBL: | TBLA_0D03510(TBLA0D03510) |
| TDL: | TDEL_0B04070(TDEL0B04070) |
| KAF: | KAFR_0G03470(KAFR0G03470) |
| KNG: | KNAG_0M00670(KNAG0M00670) |
| LBG: | 92208426(LODBEIA_P32300) |
| CAL: | CAALFM_C307710WA(ABD1) |
| YLI: | 2909207(YALI2_B00126g) |
| NTE: | NEUTE1DRAFT132027(NEUTE1DRAFT_132027) |
| SMP: | 10802174(SMAC4_06142) |
| FPOA: | FPOAC1_004547(ABD1) |
| TATV: | 25779184(TrAtP1_008748) |
| PLJ: | 28884848(PLICBS_006051) |
| CDET: | 87945331(CDEST_08828) |
| BFU: | BCIN_13g01620(Bcabd1) |
| PTRR: | 6344751(PtrM4_049820) |
| CCAC: | CcaHIS019_0400440(ABD1) |
| SCM: | SCHCO_02606534(SCHCODRAFT_02606534) |
| DDI: | DDB_G0278479 DDB_G0288673 |
| DPP: | DICPUDRAFT_42334 DICPUDRAFT_89950 |
| EHI: | EHI_040480 EHI_095040(313.t00006) |
| LMAT: | 92510186(LSCM1_00013) |
| LOI: | 92356037(LSCM4_00011) |
| LEIS: | 94175675(GH5_00015) |
| LENR: | 94167319(CUR178_00013) |
| LEIN: | 94183793(JIQ42_00012) |
| PHET: | 94286141(JKF63_00010) |
| NGR: | NAEGRDRAFT_51800 NAEGRDRAFT_60167 |
| TVA: | TVAG_2v0213620 TVAG_2v0930760 |
| SSAO: | 94296703(SS50377_22680) |
| EHX: | EMIHUDRAFT_69653 EMIHUDRAFT_73968 |
| GTT: | GUITHDRAFT_105843 GUITHDRAFT_46422 |
» show all
|
| Reference |
|
| Authors |
Ensinger MJ, Martin SA, Paoletti E, Moss B. |
| Title |
Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. |
| Journal |
|
| Reference |
|
| Authors |
Groner Y, Gilboa E, Aviv H. |
| Title |
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. |
| Journal |
|
| Reference |
|
| Authors |
Martin SA, Moss B. |
| Title |
Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions. |
| Journal |
J Biol Chem 250:9330-5 (1975) |
| Reference |
|
| Authors |
Martin SA, Paoletti E, Moss B. |
| Title |
Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions. |
| Journal |
J Biol Chem 250:9322-9 (1975) |
| Reference |
|
| Authors |
Mao X, Schwer B, Shuman S. |
| Title |
Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. |
| Journal |
|
| Reference |
|
| Authors |
Pillutla RC, Yue Z, Maldonado E, Shatkin AJ |
| Title |
Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. |
| Journal |
|
| Reference |
|
| Authors |
Tsukamoto T, Shibagaki Y, Niikura Y, Mizumoto K. |
| Title |
Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. |
| Journal |
|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.56 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.56 |
|