KEGG   ENZYME: 2.1.1.57Help
Entry
EC 2.1.1.57                 Enzyme                                 

Name
methyltransferase cap1;
messenger ribonucleate nucleoside 2'-methyltransferase;
messenger RNA (nucleoside-2'-)-methyltransferase;
MTR1;
cap1-MTase;
mRNA (nucleoside-2'-O)-methyltransferase (ambiguous);
S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] 2-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] [RN:R03922]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] [CPD:C02339]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] [CPD:C04802]
Comment
This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. This methylation event is known as cap1, and occurrs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine [6].
History
EC 2.1.1.57 created 1981 (EC 2.1.1.58 created 1981, incorporated 1984), modified 2014
Orthology
K14589  cap1 methyltransferase
K21516  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Genes
HSA: 23070(CMTR1)
PTR: 471998(CMTR1)
PPS: 100973075(CMTR1)
GGO: 101137720(CMTR1)
PON: 100172922(CMTR1)
NLE: 100603379(CMTR1)
MCC: 719402(CMTR1)
MCF: 102122892(CMTR1)
CSAB: 103221567(CMTR1)
RRO: 104682893(CMTR1)
RBB: 108528352(CMTR1)
CJC: 100388430(CMTR1)
SBQ: 101048288(CMTR1)
MMU: 74157(Cmtr1)
RNO: 309656(Cmtr1)
CGE: 100755381(Cmtr1)
NGI: 103739641(Cmtr1)
HGL: 101702635(Cmtr1)
CCAN: 109694147(Cmtr1)
OCU: 100350011(CMTR1)
TUP: 102486149(CMTR1)
CFA: 100683999(CMTR1)
AML: 100464010(CMTR1)
UMR: 103665432(CMTR1)
ORO: 101370834(CMTR1)
FCA: 101082907(CMTR1)
PTG: 102959389(CMTR1)
AJU: 106972787(CMTR1)
BTA: 509620(CMTR1)
BOM: 102286518(CMTR1)
BIU: 109577167(CMTR1)
PHD: 102330710(CMTR1)
CHX: 102183833(CMTR1)
OAS: 101123242(CMTR1)
SSC: 100154061(CMTR1)
CFR: 102519501(CMTR1)
CDK: 105087036(CMTR1)
BACU: 102999368(CMTR1)
LVE: 103084086(CMTR1)
OOR: 101285678(CMTR1)
ECB: 100064496(CMTR1)
EPZ: 103565234(CMTR1)
EAI: 106824556(CMTR1)
MYB: 102239315(CMTR1) 102261455(UBAC2)
MYD: 102752437(CMTR1)
HAI: 109395523(CMTR1)
RSS: 109438501(CMTR1)
PALE: 102890551(CMTR1)
LAV: 100676382(CMTR1)
TMU: 101344306
MDO: 100029458(CMTR1)
SHR: 100932113(CMTR1)
OAA: 100080325(CMTR1)
GGA: 421434(CMTR1)
MGP: 100550686(CMTR1)
CJO: 107311264(CMTR1)
APLA: 101791717(CMTR1)
ACYG: 106029753(CMTR1)
TGU: 100221592(CMTR1)
GFR: 102034324(CMTR1)
FAB: 101813808(CMTR1)
PHI: 102100817(CMTR1)
PMAJ: 107201841(CMTR1)
CCAE: 111927547(CMTR1)
CCW: 104684420(CMTR1)
FPG: 101914346(CMTR1)
FCH: 102046517 102046764(CMTR1)
CLV: 102095138(CMTR1)
EGZ: 104124848(CMTR1)
AAM: 106485494(CMTR1)
ASN: 102369625(CMTR1)
AMJ: 102558730(CMTR1)
PSS: 102451122(CMTR1)
CMY: 102946212(CMTR1)
CPIC: 101934896(CMTR1)
ACS: 100553490(cmtr1)
PVT: 110074654(CMTR1)
PBI: 103059677(CMTR1)
GJA: 107115268(CMTR1)
XLA: 108716524(cmtr1.L) 443938(cmtr1.S)
XTR: 100170565(cmtr1)
NPR: 108801553(CMTR1)
DRE: 393102(cmtr1)
SGH: 107593988(cmtr1) 107599383
IPU: 108275821(cmtr1)
AMEX: 103047841(cmtr1)
TRU: 101074289(cmtr1)
LCO: 104921992(cmtr1) 109138504
NCC: 104941960(cmtr1)
MZE: 101469980(cmtr1)
OLA: 101158070(cmtr1)
XMA: 102216684(cmtr1)
PRET: 103457551(cmtr1)
NFU: 107377611(cmtr1)
KMR: 108240058(cmtr1)
CSEM: 103380848(cmtr1)
LCF: 108895626(cmtr1)
SDU: 111235503(cmtr1)
HCQ: 109518088(cmtr1)
BPEC: 110175704(cmtr1)
MALB: 109954305(cmtr1)
SASA: 106608025(cmtr1)
ELS: 105006028(cmtr1)
SFM: 108936559(cmtr1)
LCM: 102345363(CMTR1)
CMK: 103177927(cmtr1)
CIN: 100185668(ftsjd2)
SPU: 580281
APLC: 110977650
SKO: 100375537
DME: Dmel_CG6379(CG6379)
DER: 6551111
DSI: Dsimw501_GD16313(Dsim_GD16313)
DWI: 6638083
MDE: 101893056
AAG: 5568541
AME: 411249
BIM: 100749013
BTER: 100644808
SOC: 105207987
AEC: 105154551
ACEP: 105619524
PBAR: 105423978
HST: 105191016
DQU: 106751073
CFO: 105249141
LHU: 105677554
PGC: 109857956
PCF: 106784014
NVI: 100123042
MDL: 103568254
TCA: 655843
DPA: 109546456
NVL: 108561637
BMOR: 101744431
PMAC: 106717956
PRAP: 110995115
HAW: 110372813
PXY: 105387481
API: 100165143
DNX: 107169461
CLEC: 106667095
ZNE: 110833726
CEL: CELE_Y53F4B.13(Y53F4B.13)
BMY: Bm1_31430
CRG: 105339251
OBI: 106877177
LAK: 106177770
SHX: MS3_10131
EGL: EGR_03163
EPA: 110244207
ADF: 107347445
HMG: 100209744
DFA: DFA_05394
SMIN: v1.2.011137.t1(symbB.v1.2.011137.t1)
 » show all
Taxonomy
Reference
1  [PMID:701281]
  Authors
Barbosa E, Moss B.
  Title
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Purification and physical properties.
  Journal
J Biol Chem 253:7692-7 (1978)
Reference
2  [PMID:701282]
  Authors
Barbosa E, Moss B.
  Title
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity.
  Journal
J Biol Chem 253:7698-702 (1978)
Reference
3  [PMID:833934]
  Authors
Boone RF, Ensinger MJ, Moss B.
  Title
Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus.
  Journal
J Virol 21:475-83 (1977)
Reference
4  [PMID:1058472]
  Authors
Ensinger MJ, Martin SA, Paoletti E, Moss B.
  Title
Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.
  Journal
Proc Natl Acad Sci U S A 72:2525-9 (1975)
DOI:10.1073/pnas.72.7.2525
Reference
5  [PMID:629955]
  Authors
Groner Y, Gilboa E, Aviv H.
  Title
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.
  Journal
Biochemistry 17:977-82 (1978)
Reference
6  [PMID:21310715]
  Authors
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
  Title
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
  Journal
Nucleic Acids Res 39:4756-68 (2011)
DOI:10.1093/nar/gkr038
  Sequence
[hsa:23070]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.57
IUBMB Enzyme Nomenclature: 2.1.1.57
ExPASy - ENZYME nomenclature database: 2.1.1.57
BRENDA, the Enzyme Database: 2.1.1.57
CAS: 61970-02-3

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