KEGG   ENZYME: 2.1.1.62Help
Entry
EC 2.1.1.62                 Enzyme                                 

Name
mRNA (2'-O-methyladenosine-N6-)-methyltransferase;
messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase;
S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA] [RN:R03788]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] [CPD:C01972]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA] [CPD:C04833]
History
EC 2.1.1.62 created 1982
Reference
1  [PMID:670176]
  Authors
Keith JM, Ensinger MJ, Mose B.
  Title
HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA.
  Journal
J Biol Chem 253:5033-9 (1978)
Reference
2  [PMID:28002401]
  Authors
Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR
  Title
Reversible methylation of m(6)Am in the 5' cap controls mRNA stability.
  Journal
Nature 541:371-375 (2017)
DOI:10.1038/nature21022
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.62
IUBMB Enzyme Nomenclature: 2.1.1.62
ExPASy - ENZYME nomenclature database: 2.1.1.62
BRENDA, the Enzyme Database: 2.1.1.62
CAS: 68009-87-0

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