KEGG   ENZYME: 2.1.1.71Help
Entry
EC 2.1.1.71                 Enzyme                                 

Name
phosphatidyl-N-methylethanolamine N-methyltransferase;
phosphatidylmonomethylethanolamine methyltransferase;
methyltransferase II;
phospholipid methyltransferase;
PLMT;
phosphatidyl-N-methylethanolamine methyltransferase;
phosphatidyl-N-monomethylethanolamine methyltransferase;
phosphatidylethanolamine methyltransferase I;
phosphatidylmonomethylethanolamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine [RN:R03424]
Reaction(KEGG)
R03424;
(other) R01320
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
phosphatidyl-N-methylethanolamine [CPD:C01241]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
phosphatidyl-N-dimethylethanolamine [CPD:C04308]
Comment
The enzyme also catalyses the transfer of a further methyl group, producing phosphatidylcholine.
History
EC 2.1.1.71 created 1984
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00550  phosphatidyl-N-methylethanolamine N-methyltransferase
K00551  phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase
K00570  phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase
Genes
HSA: 10400(PEMT)
PTR: 454478(PEMT)
PPS: 100972213(PEMT)
GGO: 101129284(PEMT)
PON: 100435357(PEMT)
NLE: 100590379(PEMT)
MCC: 699083(PEMT)
MCF: 102139053(PEMT)
CSAB: 103242475(PEMT)
RRO: 104666746(PEMT)
RBB: 108544482(PEMT)
CJC: 100408388(PEMT)
SBQ: 101027664(PEMT)
MMU: 18618(Pemt)
RNO: 25511(Pemt)
CGE: 100767954(Pemt)
NGI: 103724843(Pemt)
HGL: 101706125(Pemt)
CCAN: 109696976(Pemt)
OCU: 100342505(PEMT)
TUP: 102468555(PEMT)
CFA: 479526(PEMT)
AML: 100471478
UMR: 103658492(PEMT)
ORO: 101374319(PEMT)
FCA: 101088035(PEMT)
PTG: 102954031(PEMT)
AJU: 106981385(PEMT)
BTA: 360197(PEMT)
BOM: 106700740(PEMT)
PHD: 102343028(PEMT)
CHX: 102170908(PEMT)
OAS: 101112913(PEMT)
SSC: 397654(PEMT)
CFR: 102522081(PEMT)
CDK: 105100583(PEMT)
BACU: 103012191(PEMT)
LVE: 103070967(PEMT)
OOR: 101278054(PEMT)
ECB: 100050945(PEMT)
EPZ: 103562583(PEMT)
EAI: 106840619(PEMT)
MYB: 102263113(PEMT)
MYD: 102761259(PEMT)
HAI: 109390350(PEMT)
RSS: 109436860(PEMT)
PALE: 102891834
LAV: 100677591(PEMT)
TMU: 101353252
MDO: 100010012(PEMT)
SHR: 100934849(PEMT)
OAA: 100079865(PEMT)
GGA: 416508(PEMT)
MGP: 100543379
CJO: 107320620(PEMT)
APLA: 101800672(PEMT)
ACYG: 106032105(PEMT)
TGU: 100230786(PEMT)
GFR: 102041578(PEMT)
FAB: 101822001(PEMT)
PHI: 102111635(PEMT)
PMAJ: 107211297(PEMT)
CCAE: 111936140(PEMT)
CCW: 104684776(PEMT)
FPG: 101915767(PEMT)
FCH: 102054382(PEMT)
CLV: 102098836(PEMT)
EGZ: 104123099(PEMT)
AAM: 106487305(PEMT) 106500318
ASN: 102369991(PEMT)
AMJ: 102561567(PEMT)
PSS: 102447762(PEMT)
CMY: 102941958(PEMT)
CPIC: 101953495(PEMT)
ACS: 100567746(pemt)
PVT: 110090327(PEMT)
PBI: 103063432(PEMT)
GJA: 107124237(PEMT)
XLA: 447155(pemt.L)
XTR: 448594(pemt)
NPR: 108788740(PEMT)
DRE: 393127(pemt)
SRX: 107719881 107726260(pemt)
SANH: 107653979(pemt)
SGH: 107595637(pemt)
CCAR: 109078719(pemt)
IPU: 100528737(pemt)
AMEX: 103037752(pemt)
TRU: 101076246(pemt)
LCO: 104929229(pemt)
MZE: 101474773(pemt)
XMA: 102221066(pemt)
PRET: 103482052(pemt)
NFU: 107388266(pemt)
KMR: 108235907(pemt)
CSEM: 103382052(pemt)
LCF: 108889178(pemt)
SDU: 111220104(pemt)
HCQ: 109512037(pemt)
BPEC: 110173691(pemt)
MALB: 109972841(pemt)
SASA: 100196273(pemt)
OTW: 112223523(pemt)
ELS: 105005625(pemt)
SFM: 108930166(pemt)
LCM: 102347713(PEMT)
CMK: 103190670(pemt)
SPU: 581512
APLC: 110986061
SKO: 102807297
PRAP: 110991784
CRG: 105326242
MYI: 110462610
ADF: 107332339
ATH: AT1G80860(PLMT)
CRB: 17894426
BRP: 103853212
BOE: 106327895
THJ: 104812409
CPAP: 110821171
CIT: 102616857
TCC: 18595435
GRA: 105774093
DZI: 111318507
EGR: 104450625
GMX: 100301902(PLMT) 100527804
VRA: 106774076
VAR: 108320589
CCAJ: 109808823
CAM: 101511698
LJA: Lj0g3v0319119.1(Lj0g3v0319119.1) Lj0g3v0319129.1(Lj0g3v0319129.1)
ADU: 107472168
AIP: 107618472
LANG: 109355783
FVE: 101301023
PPER: 18782047
PMUM: 103328177
PAVI: 110763381
MDM: 103405574
CSV: 101218126
CMO: 103502819
MCHA: 111020909
CMAX: 111492722
CMOS: 111452701
CPEP: 111787888
RCU: 8280240
JCU: 105630312
HBR: 110640774
JRE: 108979108
VVI: 100258621
SLY: 101257780
SPEN: 107023731
SOT: 102581223
CANN: 107876013
NSY: 104216461
NTO: 104118378
SIND: 105166825
OEU: 111391802
HAN: 110941605
LSV: 111914861
CCAV: 112514655
DCR: 108227898
BVG: 104904873
SOE: 110805011
NNU: 104610753
OSA: 4329961
DOSA: Os02t0612100-01(Os02g0612100)
OBR: 102705597
BDI: 100822772
ATS: 109736193(LOC109736193)
SBI: 8072454
ZMA: 100276493
SITA: 101782590
PDA: 103717195
EGU: 105060175
MUS: 103983929
DCT: 110093093
PEQ: 110017882
AOF: 109843522
ATR: 18447075
PPP: 112283098
MNG: MNEG_4975
APRO: F751_5940
SCE: YJR073C(OPI3)
ERC: Ecym_3611
KMX: KLMA_30035(OPI3)
NCS: NCAS_0A12330(NCAS0A12330)
NDI: NDAI_0A03900(NDAI0A03900)
TPF: TPHA_0F03600(TPHA0F03600)
TBL: TBLA_0D03630(TBLA0D03630)
TDL: TDEL_0F00350(TDEL0F00350)
KAF: KAFR_0K02560(KAFR0K02560)
PIC: PICST_56448(OPI3)
CAL: CAALFM_C306570CA(OPI3)
CAUR: QG37_05964
SLB: AWJ20_2161(OPI3)
NCR: NCU04699
NTE: NEUTE1DRAFT124377(NEUTE1DRAFT_124377)
MGR: MGG_01295
SSCK: SPSK_07871
MAW: MAC_03502
MAJ: MAA_02204
CMT: CCM_04620
BFU: BCIN_11g00500(Bcopi3)
MBE: MBM_06023
ANI: AN1376.2
ANG: ANI_1_64074(An08g00560)
ABE: ARB_08040
TVE: TRV_04355
PNO: SNOG_06783(SNOG_06782)
PTE: PTT_09357
SPO: SPBC337.16(cho1)
CNE: CND06200
CNB: CNBD0210
ABP: AGABI1DRAFT76829(AGABI1DRAFT_76829)
ABV: AGABI2DRAFT211112(AGABI2DRAFT_211112)
MGL: MGL_0956
DDI: DDB_G0282527(pemtA) DDB_G0289645(pemtB)
DFA: DFA_01140(pemtB) DFA_05291(pemtA)
NGR: NAEGRDRAFT_4009(AM15)
LPN: lpg2158(pmtA)
LPH: LPV_2409
LPO: LPO_2222
LPM: LP6_2181(pmtA)
LPF: lpl2086
LPP: lpp2097
LPA: lpa_03098
LPE: lp12_2150
LLO: LLO_3400
LFA: LFA_0551
LOK: Loa_02535
MCA: MCA3065
NOC: Noc_0914
NHL: Nhal_1108
NWA: Nwat_0780
TEE: Tel_09350
NTT: TAO_1398
HHA: Hhal_0826
TKM: TK90_0730
TVR: TVD_03700
SLIM: SCL_1104
SVA: SVA_2165
SALN: SALB1_2218
CBAA: SRAA_1512
CBAB: SMCB_0498
EBA: ebA6680(pemT)
MLO: mll4753
MES: Meso_0681
PLA: Plav_2189
RBS: RHODOSMS8_02128(menG)
SME: SMc00414
SMX: SM11_chr3811(pmtA)
SMEL: SM2011_c00414(pmtA)
SMER: DU99_01800
SMD: Smed_3542
EAD: OV14_1225
ATU: Atu0300
ARA: Arad_0541
AVI: Avi_0349
AGR: AGROH133_03436(pmtA)
RLE: RL0333(pmtA) RL1338(pmtA)
RHL: LPU83_0386(pmtA)
RHT: NT26_4281
SHZ: shn_22230
BME: BMEI2000
BMEL: DK63_1491
BMEE: DK62_1457
BMF: BAB1_2131
BMB: BruAb1_2102(pmtA)
BABO: DK55_2061
BABR: DO74_1915
BABT: DK49_1817
BABB: DK48_58
BABU: DK53_2045
BABS: DK51_1498
BABC: DO78_1964
BMS: BR2127(pmtA)
BSI: BS1330_I2121(pmtA)
BSF: BSS2_I2061(pmtA)
BSZ: DK67_243
BSV: BSVBI22_A2123(pmtA)
BOV: BOV_2043(pmtA)
BOL: BCOUA_I2127(pmtA)
BCAR: DK60_58
BCAS: DA85_10235
BMR: BMI_I2149(pmtA)
BPP: BPI_I2185(pmtA)
BPV: DK65_1412
BVL: BF3285c1_0816(pmtA)
OAN: Oant_0788
OAH: DR92_325
BJA: bll6634(pmtA) bll6994 blr0681(pmtA)
BRS: S23_01550(pmtA) S23_13110(pmtX1) S23_16750(pmtA)
OCG: OCA5_c01120 OCA5_c26320(pmtA1) OCA5_c27610(pmtA2)
OCO: OCA4_c01120 OCA4_c26310(pmtA1) OCA4_c27600(pmtA2)
MDI: METDI3731(pmtA) METDI5092
HDN: Hden_2491
RVA: Rvan_3372
MCG: GL4_2815
HDI: HDIA_4168(ubiE_1) HDIA_4815
SIL: SPOA0294(pmtA)
RSP: RSP_0721(PmtA)
RCP: RCAP_rcc00559(pmtA)
PDE: Pden_4690
DSH: Dshi_2712
PSF: PSE_0487
PGA: PGA1_c29610(pmtA)
PGL: PGA2_c27520(pmtA)
PGD: Gal_00470
PHP: PhaeoP97_00543(pmtA_1)
PPIC: PhaeoP14_02731(pmtA)
MALG: MALG_03931
GOX: GOX1862
GOH: B932_0129
GOY: GLS_c19790(pmtA)
ACR: Acry_2168
AMV: ACMV_24160(pmtA)
GDI: GDI2102(pmtA)
GDJ: Gdia_0321
GXY: GLX_26190
GXL: H845_564
KEU: S101446_02953(pmtA)
APK: APA386B_612(pmtA)
ASZ: ASN_3042(pmtA)
TMO: TMO_1929
KST: KSMBR1_0072(pmtA_1)
PHM: PSMK_14180(pmtA)
ABAC: LuPra_03024(ubiE_5)
NDE: NIDE0511(pmtA)
NMV: NITMOv2_0425(pmtA)
NIO: NITINOP_1227(pmtA)
NJA: NSJP_1550(pmtA)
MOX: DAMO_1446(pmtA)
 » show all
Taxonomy
Reference
1  [PMID:25437]
  Authors
Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J.
  Title
Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine.
  Journal
Proc Natl Acad Sci U S A 75:1718-21 (1978)
DOI:10.1073/pnas.75.4.1718
Reference
2  [PMID:438165]
  Authors
Schneider WJ, Vance DE.
  Title
Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities.
  Journal
J Biol Chem 254:3886-91 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.71
IUBMB Enzyme Nomenclature: 2.1.1.71
ExPASy - ENZYME nomenclature database: 2.1.1.71
BRENDA, the Enzyme Database: 2.1.1.71
CAS: 67167-73-1

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