KEGG   ENZYME: 2.1.1.83Help
Entry
EC 2.1.1.83                 Enzyme                                 

Name
3,7-dimethylquercetin 4'-O-methyltransferase;
flavonol 4'-O-methyltransferase;
flavonol 4'-methyltransferase;
4'-OMT;
S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase;
3,7-dimethylquercitin 4'-O-methyltransferase [mis-spelt]
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5,3',4'-trihydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 5,3'-dihydroxy-3,7,4'-trimethoxyflavone [RN:R03456]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5,3',4'-trihydroxy-3,7-dimethoxyflavone
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5,3'-dihydroxy-3,7,4'-trimethoxyflavone
Comment
3,7-Dimethylquercetagetin can also act as acceptor. Involved with EC 2.1.1.76 quercetin 3-O-methyltransferase and EC 2.1.1.82 3-methylquercetin 7-O-methyltransferase in the methylation of quercetin to 3,7,4'-trimethylquercetin in Chrysosplenium americanum. Does not act on flavones, dihydroflavonols, or their glucosides.
History
EC 2.1.1.83 created 1989
Pathway
ec00944  Flavone and flavonol biosynthesis
Reference
1  [PMID:3994393]
  Authors
De Luca V, Ibrahim RK.
  Title
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases.
  Journal
Arch Biochem Biophys 238:596-605 (1985)
DOI:10.1016/0003-9861(85)90205-X
Reference
2  [PMID:3994394]
  Authors
De Luca V, Ibrahim RK.
  Title
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases.
  Journal
Arch Biochem Biophys 238:606-18 (1985)
DOI:10.1016/0003-9861(85)90206-1
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.83
IUBMB Enzyme Nomenclature: 2.1.1.83
ExPASy - ENZYME nomenclature database: 2.1.1.83
BRENDA, the Enzyme Database: 2.1.1.83
CAS: 96477-60-0

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