KEGG   ENZYME: 2.1.1.85Help
Entry
EC 2.1.1.85                 Enzyme                                 

Name
protein-histidine N-methyltransferase;
protein methylase IV;
protein (histidine) methyltransferase;
actin-specific histidine methyltransferase;
S-adenosyl methionine:protein-histidine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine [RN:R02627]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
protein L-histidine [CPD:C00615]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
protein Ntau-methyl-L-histidine
Comment
Highly specific for histidine residues, for example, in actin.
History
EC 2.1.1.85 created 1989
Orthology
K18803  protein-histidine N-methyltransferase
Genes
SCE: YIL110W(HPM1)
AGO: AGOS_ADL242W
ERC: Ecym_3297
KLA: KLLA0_F03663g
KMX: KLMA_80158(HPM1)
LTH: KLTH0G09768g
VPO: Kpol_1039p28
ZRO: ZYRO0D02376g
CGR: CAGL0C01331g
NCS: NCAS_0B06390(NCAS0B06390)
NDI: NDAI_0B03680(NDAI0B03680)
TPF: TPHA_0F01200(TPHA0F01200)
TBL: TBLA_0G02490(TBLA0G02490)
TDL: TDEL_0C04020(TDEL0C04020)
KAF: KAFR_0J01520(KAFR0J01520)
CAUR: QG37_06317
SLB: AWJ20_783(HPM1)
NCR: NCU00956
NTE: NEUTE1DRAFT90219(NEUTE1DRAFT_90219)
MGR: MGG_17436
SSCK: SPSK_09111
MAW: MAC_04586
MAJ: MAA_00238
CMT: CCM_06667
BFU: BCIN_02g03570(Bchpm1)
MBE: MBM_02255
ANI: AN1445.2
ANG: ANI_1_1174144(An16g08730)
ABE: ARB_06471
TVE: TRV_07091
PTE: PTT_17862
CNE: CNA06680
CNB: CNBA6500
ABP: AGABI1DRAFT123080(AGABI1DRAFT_123080)
ABV: AGABI2DRAFT225922(AGABI2DRAFT_225922)
MGL: MGL_2988
 » show all
Taxonomy
Reference
1  [PMID:3801515]
  Authors
Vijayasarathy C, Rao BS.
  Title
Partial purification and characterisation of S-adenosylmethionine:protein-histidine N-methyltransferase from rabbit skeletal muscle.
  Journal
Biochim Biophys Acta 923:156-65 (1987)
DOI:10.1016/0304-4165(87)90139-5
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.85
IUBMB Enzyme Nomenclature: 2.1.1.85
ExPASy - ENZYME nomenclature database: 2.1.1.85
BRENDA, the Enzyme Database: 2.1.1.85
CAS: 108022-17-9

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