KEGG   ENZYME: 2.1.1.90Help
Entry
EC 2.1.1.90                 Enzyme                                 

Name
methanol---corrinoid protein Co-methyltransferase;
methanol cobalamin methyltransferase;
methanol:5-hydroxybenzimidazolylcobamide methyltransferase;
MT 1 (ambiguous);
methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase;
mtaB (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
methanol + a [Co(I) methanol-specific corrinoid protein] = a [methyl-Co(III) methanol-specific corrinoid protein] + H2O [RN:R04384]
Reaction(KEGG)
R04384;
(other) R09098
Show
Substrate
methanol [CPD:C00132];
[Co(I) methanol-specific corrinoid protein]
Product
[methyl-Co(III) methanol-specific corrinoid protein];
H2O [CPD:C00001]
Comment
The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2].
Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.
History
EC 2.1.1.90 created 1989, modified 2012
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K04480  methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase
Genes
DTI: Desti_2034
CFM: BJL90_02615
CCL: Clocl_0783
DKU: Desku_0051
TJR: TherJR_0987
DOR: Desor_2803
DMI: Desmer_2205
ELM: ELI_2003
AWO: Awo_c22760(mttB18)
MTA: Moth_1209
TPZ: Tph_c03590(mtaB)
MST: Msp_0184(mtaB3) Msp_0186(mtaB2) Msp_0188(mtaB1) Msp_0819(mtaB4)
MSI: Msm_0515
MCUB: MCBB_1154(mtaB)
MEAR: Mpt1_c05090(mtaB)
MAC: MA_0455(mtaB1) MA_1616(mtaB3) MA_4392(mtaB2)
MMA: MM_0175(mtaB) MM_1074(mtaB) MM_1647
RCI: RCIX1974(mtaB)
 » show all
Taxonomy
Reference
1  [PMID:6438059]
  Authors
van der Meijden P, te Brommelstroet BW, Poirot CM, van der Drift C, Vogels GD.
  Title
Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri.
  Journal
J Bacteriol 160:629-35 (1984)
  Sequence
Reference
2  [PMID:10215883]
  Authors
Sauer K, Thauer RK.
  Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
  Journal
Eur J Biochem 261:674-81 (1999)
DOI:10.1046/j.1432-1327.1999.00355.x
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.90
IUBMB Enzyme Nomenclature: 2.1.1.90
ExPASy - ENZYME nomenclature database: 2.1.1.90
BRENDA, the Enzyme Database: 2.1.1.90
CAS: 86611-98-5

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