KEGG   ENZYME: 2.1.1.99Help
Entry
EC 2.1.1.99                 Enzyme                                 

Name
3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase;
16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase;
NMT;
16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase;
S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-hydroxy-16-methoxy-2,3-dihydrotabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline [RN:R04013]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-hydroxy-16-methoxy-2,3-dihydrotabersonine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
deacetoxyvindoline [CPD:C02673]
Comment
Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle Catharanthus roseus.
History
EC 2.1.1.99 created 1990, modified 2005
Pathway
ec00901  Indole alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21896  3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
Reference
1
  Authors
De Luca, V., Balsevich, J., Tyler, R.T., Eilert, U., Panchuk, B.D. and Kurz, W.G.W.
  Title
Biosynthesis of indole alkaloids - developmental regulation of the biosynthetic-pathway from tabersonine to vindoline in Catharanthus roseus.
  Journal
J Plant Physiol 125:147-156 (1986)
Reference
2  [PMID:16665811]
  Authors
De Luca V, Cutler AJ
  Title
Subcellular Localization of Enzymes Involved in Indole Alkaloid Biosynthesis in Catharanthus roseus.
  Journal
Plant Physiol 85:1099-1102 (1987)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.99
IUBMB Enzyme Nomenclature: 2.1.1.99
ExPASy - ENZYME nomenclature database: 2.1.1.99
BRENDA, the Enzyme Database: 2.1.1.99
CAS: 113478-40-3

DBGET integrated database retrieval system