| Entry |
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| Name |
glutamate formimidoyltransferase;
glutamate formyltransferase;
formiminoglutamic acid transferase;
formiminoglutamic formiminotransferase;
glutamate formiminotransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
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| Sysname |
5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase
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| Reaction(IUBMB) |
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate [RN: R02287]
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| Reaction(KEGG) |
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| Substrate |
5-formimidoyltetrahydrofolate [CPD: C00664];
L-glutamate [CPD: C00025]
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| Product |
tetrahydrofolate [CPD: C00101];
N-formimidoyl-L-glutamate [CPD: C00439]
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| Comment |
A pyridoxal-phosphate protein. Also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate (a reaction formerly listed as EC 2.1.2.6). In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
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| History |
EC 2.1.2.5 created 1961, modified 2000 (EC 2.1.2.6 created 1965, incorporated 1984)
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| Pathway |
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| Orthology |
| K00603 | glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase |
| K13990 | glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase |
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| Genes |
» show all
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| Reference |
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| Authors |
MILLER A, WAELSCH H. |
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| Title |
Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid. |
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| Journal |
J Biol Chem 228:397-417 (1957) |
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| Reference |
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| Authors |
SILVERMAN M, KERESZTESY JC, KOVAL GJ, GARDINER RC. |
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| Title |
Citrovorum factor and the synthesis of formylglutamic acid. |
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| Journal |
J Biol Chem 226:83-94 (1957) |
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| Reference |
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| Authors |
TABOR H, WYNGARDEN L. |
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| Title |
The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid. |
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| Journal |
J Biol Chem 234:1830-46 (1959) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.2.5 |
| ExPASy - ENZYME nomenclature database: | 2.1.2.5 |
| BRENDA, the Enzyme Database: | 2.1.2.5 |
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