KEGG   ENZYME: 2.1.3.1Help
Entry
EC 2.1.3.1                  Enzyme                                 

Name
methylmalonyl-CoA carboxytransferase;
transcarboxylase;
methylmalonyl coenzyme A carboxyltransferase;
methylmalonyl-CoA transcarboxylase;
oxalacetic transcarboxylase;
methylmalonyl-CoA carboxyltransferase;
methylmalonyl-CoA carboxyltransferase;
(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase;
(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase carboxytransferase [incorrect]
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
(S)-methylmalonyl-CoA:pyruvate carboxytransferase
Reaction(IUBMB)
(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate [RN:R00930]
Reaction(KEGG)
R00930;
(other) R00353
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Substrate
(S)-methylmalonyl-CoA [CPD:C00683];
pyruvate [CPD:C00022]
Product
propanoyl-CoA [CPD:C00100];
oxaloacetate [CPD:C00036]
Comment
A biotinyl-protein, containing cobalt and zinc.
History
EC 2.1.3.1 created 1961
Pathway
ec00640  Propanoate metabolism
Orthology
K03416  methylmalonyl-CoA carboxyltransferase 5S subunit
K17489  methylmalonyl-CoA carboxyltransferase 12S subunit
K17490  methylmalonyl-CoA carboxyltransferase 1.3S subunit
Genes
GBM: Gbem_0334 Gbem_0335 Gbem_0336 Gbem_0337
GEM: GM21_0316 GM21_0317 GM21_0318 GM21_0319
PPD: Ppro_0033 Ppro_0034 Ppro_0035 Ppro_3082 Ppro_3083 Ppro_3084
DTO: TOL2_C38240
RSU: NHU_02467
RHM: B5V46_07290
SRI: SELR_10340
MHG: MHY_07420
CEF: CE0804 CE0805 CE0806 CE0807
CDI: DIP0739(pycB) DIP0740(mmdA) DIP0741 DIP0742
 » show all
Taxonomy
Reference
1  [PMID:2920730]
  Authors
Hoffmann A, Hilpert W, Dimroth P.
  Title
The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
  Journal
Eur J Biochem 179:645-50 (1989)
DOI:10.1111/j.1432-1033.1989.tb14596.x
Reference
2  [PMID:16590594]
  Authors
Swick RW, Wood HG.
  Title
THE ROLE OF TRANSCARBOXYLATION IN PROPIONIC ACID FERMENTATION.
  Journal
Proc Natl Acad Sci U S A 46:28-41 (1960)
DOI:10.1073/pnas.46.1.28
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.1
IUBMB Enzyme Nomenclature: 2.1.3.1
ExPASy - ENZYME nomenclature database: 2.1.3.1
UM-BBD (Biocatalysis/Biodegradation Database): 2.1.3.1
BRENDA, the Enzyme Database: 2.1.3.1
CAS: 9029-86-1

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