KEGG   ENZYME: 2.1.3.11Help
Entry
EC 2.1.3.11                 Enzyme                                 

Name
N-succinylornithine carbamoyltransferase;
succinylornithine transcarbamylase;
N-succinyl-L-ornithine transcarbamylase;
SOTCase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl phosphate:N2-succinyl-L-ornithine carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + N2-succinyl-L-ornithine = phosphate + N-succinyl-L-citrulline [RN:R08937]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
N2-succinyl-L-ornithine [CPD:C03415]
Product
phosphate [CPD:C00009];
N-succinyl-L-citrulline [CPD:C18048]
Comment
This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 -> Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine.
History
EC 2.1.3.11 created 2008
Orthology
K13043  N-succinyl-L-ornithine transcarbamylase
Genes
BTH: BT_3717
BTHO: Btheta7330_04579(argF')
BFR: BF0494
BFS: BF9343_0422
BFG: BF638R_0504(argF)
BFB: VU15_01710
BVU: BVU_0551
BHL: Bache_0330
BSA: Bacsa_1454
BXY: BXY_47780
BOA: Bovatus_03821(argF')
BCEL: BcellWH2_02177(argF')
BACC: BRDCF_p436(argF)
PBT: ING2E5B_0150(argF')
PMUC: ING2E5A_0734(argF')
PDI: BDI_2259
TFO: BFO_2797(argF')
PSAC: PSM36_2740(argF')
APS: CFPG_376
PRU: PRU_2210
AFD: Alfi_1680
ASH: AL1_17560
DORI: FH5T_10030
CPI: Cpin_6553
FLN: FLA_5677
PHE: Phep_4206
SMIZ: 4412673_03356(argF')
MUC: MuYL_3044
MGOT: MgSA37_02913(argF')
CHU: CHU_3085(argF)
DFE: Dfer_4418
SLI: Slin_1156
LBY: Lbys_2153
FAE: FAES_2044
PSEZ: HME7025_02012(argF)
HSW: Hsw_1096
FLM: MY04_2040
GFO: GFO_2103(argF)
GFL: GRFL_0166
FJO: Fjoh_3430
FJG: BB050_04250(argF')
FBR: FBFL15_2069(argF)
ZPR: ZPR_2793
MARM: YQ22_05880
CBAL: M667_02655
CBAT: M666_02655
DOK: MED134_11931(argF)
DDO: I597_1160(argF')
ZGA: ZOBELLIA_1234(argF')
MLT: VC82_1017
POM: MED152_02640(argF)
EAO: BD94_3864
ELB: VO54_02834(argF')
MYR: MYRA21_1098(argF)
MPW: MPR_3623
CHZ: CHSO_1869(argF)
WIN: WPG_1864
TJE: TJEJU_1874(argF)
TMAR: MARIT_0480(argF')
AALG: AREALGSMS7_00803(argF')
SPON: HME9304_01039(argF)
KOS: KORDIASMS9_04521(argF')
MARF: CJ739_2110
FBA: FIC_00881
FBU: UJ101_02620(argF)
SMG: SMGWSS_114(argF)
SMS: SMDSEM_122(argF)
SUM: SMCARI_134(argF)
SMV: SULALF_092(argF)
SMUB: IM46_202
SMUM: SMML_v1c00730(argF)
SMUE: SMTETUND_121(argF')
SMUP: SMPSPU_134(argF)
BBL: BLBBGE_318(argF)
BPI: BPLAN_322(argF)
BMM: MADAR_053(argF)
BCP: BLBCPU_299(argF)
BBG: BGIGA_315(argF)
BLP: BPAA_326(argF)
BLU: K645_1476
UDI: ASNER_235(argF)
 » show all
Taxonomy
Reference
1  [PMID:16704984]
  Authors
Shi D, Morizono H, Cabrera-Luque J, Yu X, Roth L, Malamy MH, Allewell NM, Tuchman M
  Title
Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis.
  Journal
J Biol Chem 281:20623-31 (2006)
DOI:10.1074/jbc.M601229200
  Sequence
Reference
2  [PMID:17600144]
  Authors
Shi D, Yu X, Cabrera-Luque J, Chen TY, Roth L, Morizono H, Allewell NM, Tuchman M
  Title
A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase.
  Journal
Protein Sci 16:1689-99 (2007)
DOI:10.1110/ps.072919907
  Sequence
[bfr:BF0494]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.11
IUBMB Enzyme Nomenclature: 2.1.3.11
ExPASy - ENZYME nomenclature database: 2.1.3.11
BRENDA, the Enzyme Database: 2.1.3.11

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