KEGG   ENZYME: 2.1.3.9Help
Entry
EC 2.1.3.9                  Enzyme                                 

Name
N-acetylornithine carbamoyltransferase;
acetylornithine transcarbamylase;
N-acetylornithine transcarbamylase;
AOTC;
carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase;
AOTCase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline [RN:R07245]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
N2-acetyl-L-ornithine [CPD:C00437]
Product
phosphate [CPD:C00009];
N-acetyl-L-citrulline [CPD:C15532]
Comment
Differs from EC 2.1.3.3, ornithine carbamoyltransferase. This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate.
History
EC 2.1.3.9 created 2005
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K09065  N-acetylornithine carbamoyltransferase
Genes
XFA: XF_0998
XFT: PD_0290(argF)
XFM: Xfasm12_0314
XFN: XfasM23_0284
XFF: XFLM_06825
XFL: P303_00885
XFS: D934_02520
XFH: XFHB_10450
XTW: AB672_01675
XCC: XCC2249(argF)
XCB: XC_1869
XCP: XCR_2518
XCV: XCV2551(argF)
XAX: XACM_2361(argF)
XAC: XAC2352(argF)
XCI: XCAW_02017(argF)
XFU: XFF4834R_chr23570(argF)
XOO: XOO2676(argF)
XOM: XOO2522(XOO2522)
XOP: PXO_00353
XOR: XOC_2751
XAL: XALC_1896(argF)
XPH: XppCFBP6546_01255(XppCFBP6546P_01255)
SML: Smlt3302
SMT: Smal_2729
SMZ: SMD_2874
SACZ: AOT14_15980(pyrB_2)
PSUW: WQ53_01270
PSD: DSC_08070
LAB: LA76x_3276(argF)
LAQ: GLA29479_4813(argF')
LCP: LC55x_3309(argF)
LGU: LG3211_1887(argF)
LEZ: GLE_1836
LEM: LEN_3148
DKO: I596_2178
KKO: Kkor_0543
KGE: TQ33_1837
PPNO: DA70_13840
PPNM: LV28_25530
PPUL: RO07_10980
PSPU: NA29_06805
PAPI: SG18_11385
MXA: MXAN_5104(argF)
CCX: COCOR_02390(argF)
SUR: STAUR_5869(argF)
SCL: sce0074(argF1)
MTA: Moth_1996
ATM: ANT_01250
SRU: SRU_2218
SRM: SRM_02445(argF)
RMR: Rmar_0946
BARC: AOA65_0973(argF_2)
 » show all
Taxonomy
Reference
1  [PMID:15731101]
  Authors
Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M.
  Title
Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria.
  Journal
J Biol Chem 280:14366-9 (2005)
DOI:10.1074/jbc.C500005200
  Sequence
[xcc:XCC2249]
Reference
2  [PMID:16585758]
  Authors
Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M.
  Title
Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis.
  Journal
J Bacteriol 188:2974-82 (2006)
DOI:10.1128/JB.188.8.2974-2982.2006
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.9
IUBMB Enzyme Nomenclature: 2.1.3.9
ExPASy - ENZYME nomenclature database: 2.1.3.9
BRENDA, the Enzyme Database: 2.1.3.9
CAS: 890853-54-0

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