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Entry
EC 2.2.1.10                 Enzyme                                 

Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
ADH synthase;
ADHS;
MJ0400 (gene name)
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Reaction(IUBMB)
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate [RN:R08568]
Reaction(KEGG)
Substrate
L-aspartate 4-semialdehyde [CPD:C00441];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848]
Product
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
2,3-dioxopropyl phosphate [CPD:C16849]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.10 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K16306  fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Genes
MRM: A7982_01287
BMET: BMMGA3_07340
SRW: TUE45_01349(lsrF)
MINF: MESINF_1405
MJA: MJ_0400
MFE: Mefer_1187
MVU: Metvu_1437
MFS: MFS40622_1668
MIF: Metin_0016
MJH: JH146_1314
MMP: MMP0686
MMD: GYY_02835
MAE: Maeo_0316
MVO: Mvol_0365
MTH: MTH_579
MMG: MTBMA_c09600(fbaB)
METC: MTCT_0503
MWO: MWSIV6_0939(aroA')
METE: tca_00548(griI)
MST: Msp_0091
MSI: Msm_0056
MRU: mru_0997
MEB: Abm4_0656
MMIL: sm9_1016
MEYE: TL18_05340
MOL: YLM1_0540
METH: MBMB1_1070
MFC: BRM9_1272
MCUB: MCBB_0939(aroA')
MFV: Mfer_0600
MKA: MK1409(fbaB)
AFU: AF_0108
FPL: Ferp_0600
GAC: GACE_1261
GAH: GAH_01502
MEAR: Mpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MARC: AR505_0508
MAC: MA_0439 MA_4591(deoC)
MBG: BN140_2035(fbaA1) BN140_2036(fbaA3)
MEZ: Mtc_1383(aroF) Mtc_1667
RCI: RRC153(aroF)
HAL: VNG_0309C
HSL: OE_1472F(fba2)
HHB: Hhub_1454
HALH: HTSR_1439(fba2)
HHSR: HSR6_1511(fba2)
HSU: HLASF_0623(fba1)
HSF: HLASA_0619(fba1)
HMA: rrnAC1881(deoC2)
HHI: HAH_2396(fbaB2)
NPH: NP_3160A(fba2)
NMO: Nmlp_1197(fba2)
HUT: Huta_1178
HTI: HTIA_1098
HMU: Hmuk_3036
HWA: HQ_1156A(fba2)
HWC: Hqrw_1193(fba2)
HVO: HVO_0790(fba2)
HME: HFX_0749(fbaB)
HLA: Hlac_1274
HTU: Htur_0853
NMG: Nmag_2815
NAT: NJ7G_4134
SALI: L593_00075
NMR: Nmar_0553
NID: NPIRD3C_1721(aroA)
NIN: NADRNF5_1625(aroA)
NCT: NMSP_1118(aroA'_2)
NGA: Ngar_c16210(aroGFH)
NVN: NVIE_005850(aroGFH)
NEV: NTE_01960
TAA: NMY3_02544(griI)
NCV: NCAV_0390(aroGFH)
NBV: T478_0480
NDV: NDEV_0554(aroA)
BARB: AOA66_0830(aroA')
LOKI: Lokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
 » show all
Taxonomy
Reference
1  [PMID:15182204]
  Authors
White RH.
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
3  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry 46:10562-71 (2007)
DOI:10.1021/bi700934v
  Sequence
[mja:MJ_0400]
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.10
IUBMB Enzyme Nomenclature: 2.2.1.10
ExPASy - ENZYME nomenclature database: 2.2.1.10
BRENDA, the Enzyme Database: 2.2.1.10

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