KEGG   ENZYME: 2.2.1.11Help
Entry
EC 2.2.1.11                 Enzyme                                 

Name
6-deoxy-5-ketofructose 1-phosphate synthase;
DKFP synthase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Reaction(IUBMB)
(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10049];
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10050]
Reaction(KEGG)
Substrate
2-oxopropanal [CPD:C00546];
D-fructose 1,6-bisphosphate [CPD:C00354];
D-fructose 1-phosphate [CPD:C01094]
Product
D-glyceraldehyde 3-phosphate [CPD:C00118];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.11 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Genes
MJA: MJ_1585
MFE: Mefer_0658
MVU: Metvu_0368
MFS: MFS40622_0194
MIF: Metin_0355
MJH: JH146_0289
MIG: Metig_0068
MMP: MMP0293
MMQ: MmarC5_1380
MMX: MmarC6_0660
MMD: GYY_01500
MAE: Maeo_0690
MVO: Mvol_1341
MBAK: MSBR3_2683
MMA: MM_0714
MMAC: MSMAC_0605
METM: MSMTP_0658
MTHE: MSTHC_0965
MTHR: MSTHT_2315
MHOR: MSHOH_0711
MPY: Mpsy_1203
MTP: Mthe_0380
MHI: Mhar_2267
MHU: Mhun_1466
MLA: Mlab_1135
MEMA: MMAB1_2969
MPI: Mpet_1339
MPL: Mpal_0799
 » show all
Taxonomy
Reference
1  [PMID:17014089]
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.11
IUBMB Enzyme Nomenclature: 2.2.1.11
ExPASy - ENZYME nomenclature database: 2.2.1.11
BRENDA, the Enzyme Database: 2.2.1.11

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