KEGG   ENZYME: 2.2.1.8Help
Entry
EC 2.2.1.8                  Enzyme                                 

Name
fluorothreonine transaldolase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
fluoroacetaldehyde:L-threonine aldehydetransferase
Reaction(IUBMB)
L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine [RN:R07247]
Reaction(KEGG)
Substrate
L-threonine [CPD:C00188];
fluoroacetaldehyde [CPD:C15488]
Product
acetaldehyde [CPD:C00084];
4-fluoro-L-threonine [CPD:C15533]
Comment
A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.
History
EC 2.2.1.8 created 2003
Orthology
K18847  fluorothreonine transaldolase
Genes
NBR: O3I_021630(glyA)
SCT: SCAT_p0562(4-FTase)
SCY: SCATT_p11780
ACTN: L083_1811
Taxonomy
Reference
1  [PMID:12404452]
  Authors
Murphy CD, O'Hagan D, Schaffrath C.
  Title
Identification of a PLP-Dependent Threonine Transaldolase: A Novel Enzyme Involved in 4-Fluorothreonine Biosynthesis in Streptomyces cattleya This work was supported by the Biotechnological and Biological Sciences Research Council and the University of St Andrews.
  Journal
Angew Chem Int Ed Engl 40:4479-4481 (2001)
DOI:10.1002/1521-3773(20011203)40:23<4479::AID-ANIE4479>3.0.CO;2-1
Reference
2  [PMID:12738270]
  Authors
Murphy CD, Schaffrath C, O'Hagan D.
  Title
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya.
  Journal
Chemosphere 52:455-61 (2003)
DOI:10.1016/S0045-6535(03)00191-7
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.8
IUBMB Enzyme Nomenclature: 2.2.1.8
ExPASy - ENZYME nomenclature database: 2.2.1.8
BRENDA, the Enzyme Database: 2.2.1.8
CAS: 403503-13-9

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