KEGG   ENZYME: 2.3.1.108Help
Entry
EC 2.3.1.108                Enzyme                                 

Name
alpha-tubulin N-acetyltransferase;
alpha-tubulin acetylase;
TAT;
alpha-tubulin acetyltransferase;
tubulin N-acetyltransferase;
acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase;
acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine [RN:R04192]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
[alpha-tubulin]-L-lysine [CPD:C03318]
Product
CoA [CPD:C00010];
[alpha-tubulin]-N6-acetyl-L-lysine [CPD:C04149]
Comment
The enzyme from Chlamydomonas flagella also acetylates mammalian brain alpha-tubulin.
History
EC 2.3.1.108 created 1989
Orthology
K19573  alpha-tubulin N-acetyltransferase 1
Genes
HSA: 79969(ATAT1)
PTR: 100612548(ATAT1)
PPS: 100975033(ATAT1)
GGO: 101125931(ATAT1)
PON: 100190967(ATAT1)
NLE: 100595319(ATAT1)
MCC: 100141388(ATAT1)
MCF: 102135176(ATAT1)
CSAB: 103221829(ATAT1)
RRO: 104666191(ATAT1)
RBB: 108522570(ATAT1)
CJC: 100388531(ATAT1)
SBQ: 101037052(ATAT1)
MMU: 73242(Atat1)
RNO: 361789(Atat1)
CGE: 100764669(Atat1)
NGI: 103740567(Atat1)
HGL: 101705887(Atat1)
CCAN: 109693536(Atat1)
OCU: 100358006(ATAT1)
TUP: 102486128(ATAT1)
CFA: 477580(ATAT1)
AML: 100473989(ATAT1)
UMR: 103664999(ATAT1)
ORO: 101368740(ATAT1)
FCA: 101093356(ATAT1)
PTG: 102966181(ATAT1)
AJU: 106966611(ATAT1)
BTA: 786491(ATAT1)
BOM: 102275558(ATAT1)
BIU: 109577111(ATAT1)
PHD: 102332142(ATAT1)
CHX: 102183555(ATAT1)
OAS: 101106803(ATAT1)
SSC: 100144480(ATAT1)
CFR: 102504889(ATAT1)
CDK: 105087501(ATAT1)
BACU: 103016955(ATAT1)
LVE: 103083275(ATAT1)
OOR: 101273516(ATAT1)
ECB: 100055595(ATAT1)
EPZ: 103567174(ATAT1)
EAI: 106825481(ATAT1)
MYB: 102240400(ATAT1)
MYD: 102762964(ATAT1)
HAI: 109376104(ATAT1)
RSS: 109437867(ATAT1)
PALE: 102879916(ATAT1)
LAV: 100664992(ATAT1)
TMU: 101361158
MDO: 100024215(ATAT1)
SHR: 100919522(ATAT1)
OAA: 103166272(ATAT1)
PHI: 102104188(ATAT1)
CCAE: 111942560(ATAT1)
ASN: 102379630(ATAT1)
AMJ: 102573069(ATAT1)
PSS: 102444571(ATAT1)
CMY: 102941891(ATAT1)
CPIC: 101936201(ATAT1)
ACS: 100561358(atat1)
PVT: 110089317(ATAT1)
GJA: 107111806(ATAT1)
XLA: 734258(atat1.L) 735057(atat1.S)
XTR: 100038151(atat1)
NPR: 108790405(ATAT1)
DRE: 406389(atat1)
IPU: 108272794(atat1)
AMEX: 103043739(atat1)
TRU: 101074501(atat1)
LCO: 104931069(atat1)
MZE: 101473057(atat1)
OLA: 101172832(atat1)
XMA: 102224331(atat1)
PRET: 103471914(atat1)
NFU: 107383265(atat1)
KMR: 108248583(atat1)
CSEM: 103384383 103394495(atat1)
LCF: 108896379(atat1)
SDU: 111220869(atat1)
HCQ: 109515158(atat1)
BPEC: 110161191(atat1)
MALB: 109974587(atat1)
SASA: 106589060(atat1)
ELS: 105012343(atat1)
SFM: 108935682(atat1)
LCM: 102353700(ATAT1)
CIN: 100180842
SPU: 581275
APLC: 110976410
SKO: 100372923
DME: Dmel_CG17003(CG17003) Dmel_CG3967(CG3967)
DPE: 6598554
DSI: Dsimw501_GD12926(Dsim_GD12926) Dsimw501_GD15558(Dsim_GD15558)
AAG: 5570947
AME: 726664
BIM: 100743036
BTER: 100649139
SOC: 105201818
AEC: 105145755
ACEP: 105624179
PBAR: 105428664
HST: 105190371
DQU: 106742357
CFO: 105252940
LHU: 105678633
PGC: 109859797
PCF: 106787522
NVI: 100121551
MDL: 103573516
TCA: 660866
DPA: 109541846
NVL: 108569703
BMOR: 101741407
PRAP: 110999361
HAW: 110381403
PXY: 105385329
ZNE: 110831576
FCD: 110855937
TUT: 107361133
CEL: CELE_F57H12.7(mec-17) CELE_W06B11.1(atat-2)
CBR: CBG14763 CBG17726(Cbr-mec-17)
BMY: Bm1_13540
CRG: 105336584
MYI: 110464956
OBI: 106875308
EGL: EGR_05466
EPA: 110243359
ADF: 107337067
HMG: 101237472
MNG: MNEG_1043
SMIN: v1.2.037027.t1(symbB.v1.2.037027.t1) v1.2.037027.t2(symbB.v1.2.037027.t2)
SPAR: SPRG_08206
 » show all
Taxonomy
Reference
1  [PMID:4066751]
  Authors
Greer K, Maruta H, L'Hernault SW, Rosenbaum JL.
  Title
Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella.
  Journal
J Cell Biol 101:2081-4 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.108
IUBMB Enzyme Nomenclature: 2.3.1.108
ExPASy - ENZYME nomenclature database: 2.3.1.108
BRENDA, the Enzyme Database: 2.3.1.108
CAS: 99889-90-4

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