KEGG   ENZYME: 2.3.1.135Help
Entry
EC 2.3.1.135                Enzyme                                 

Name
phosphatidylcholine---retinol O-acyltransferase;
lecithin---retinol acyltransferase;
phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase;
lecithin:retinol acyltransferase;
lecithin-retinol acyltransferase;
retinyl ester synthase;
LRAT;
lecithin retinol acyl transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + retinol---[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] [RN:R04514]
Reaction(KEGG)
Substrate
phosphatidylcholine [CPD:C00157];
retinol---[cellular-retinol-binding-protein]
Product
2-acylglycerophosphocholine;
retinyl-ester---[cellular-retinol-binding-protein]
Comment
A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.
History
EC 2.3.1.135 created 1992, modified 2011
Pathway
ec00830  Retinol metabolism
Orthology
K00678  phosphatidylcholine-retinol O-acyltransferase
Genes
HSA: 9227(LRAT)
PTR: 471328(LRAT)
PPS: 100990532(LRAT)
GGO: 101135395(LRAT)
PON: 100432491(LRAT)
NLE: 100579669(LRAT)
MCC: 698871(LRAT)
MCF: 102123283(LRAT)
CSAB: 103236423(LRAT)
RRO: 104657120(LRAT)
RBB: 108529031(LRAT)
CJC: 100414604(LRAT)
SBQ: 101042985(LRAT)
MMU: 79235(Lrat)
RNO: 64047(Lrat)
CGE: 100769559(Lrat)
NGI: 103751034(Lrat)
HGL: 101722664(Lrat)
CCAN: 109677811(Lrat)
OCU: 100354707(LRAT)
TUP: 102476648(LRAT)
CFA: 482660(LRAT)
AML: 100482038(LRAT)
UMR: 103658037(LRAT)
ORO: 101384293(LRAT)
FCA: 101092432(LRAT)
PTG: 102965792(LRAT)
AJU: 106982446(LRAT)
BTA: 281285(LRAT)
BOM: 102264381(LRAT)
BIU: 109571479(LRAT)
PHD: 102326978(LRAT)
CHX: 102183532(LRAT)
SSC: 100513994(LRAT)
CFR: 102520637(LRAT)
CDK: 105089285(LRAT)
BACU: 103000637(LRAT)
LVE: 103091446(LRAT)
OOR: 101278519(LRAT)
ECB: 100069704(LRAT)
EPZ: 103553820(LRAT)
EAI: 106832954(LRAT)
MYB: 102261540(LRAT)
MYD: 102758952(LRAT)
HAI: 109382001(LRAT)
RSS: 109448096(LRAT)
PALE: 102888347(LRAT)
LAV: 100667142(LRAT)
TMU: 101341410
MDO: 100017333(LRAT)
SHR: 100931949(LRAT)
OAA: 100080154(LRAT)
GGA: 422403(LRAT)
MGP: 104910504(LRAT)
CJO: 107313043(LRAT)
APLA: 101795343(LRAT)
TGU: 100224470(LRAT)
FAB: 101813271(LRAT)
PHI: 102105659(LRAT)
PMAJ: 107202673(LRAT)
FPG: 106112170(LRAT)
FCH: 102048889(LRAT)
CLV: 102087929(LRAT)
AAM: 106492096(LRAT)
ASN: 102378402(LRAT)
AMJ: 102557704(LRAT)
PSS: 102463592(LRAT)
CMY: 102938217(LRAT)
CPIC: 101949409(LRAT)
ACS: 100552136(lrat)
PVT: 110072772(LRAT)
PBI: 103061458(LRAT)
GJA: 107109450(LRAT)
XTR: 394746(lrat)
NPR: 108788202 108788203(LRAT)
DRE: 553239(lrata) 553501(lratb)
NCC: 104949063 104966386(lrat)
CSEM: 103383311 103389580(lrat)
LCM: 102361576(LRAT)
CMK: 103189387(lrat)
FCD: 110849237
EPA: 110238919
 » show all
Taxonomy
Reference
1  [PMID:3410848]
  Authors
MacDonald PN, Ong DE.
  Title
Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine.
  Journal
J Biol Chem 263:12478-82 (1988)
  Sequence
[rno:64047]
Reference
2  [PMID:2722792]
  Authors
Saari JC, Bredberg DL.
  Title
Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes.
  Journal
J Biol Chem 264:8636-40 (1989)
  Sequence
[bta:281285]
Reference
3  [PMID:8489497]
  Authors
Saari JC, Bredberg DL, Farrell DF
  Title
Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase.
  Journal
Biochem J 291 ( Pt 3):697-700 (1993)
Reference
4  [PMID:9767084]
  Authors
Mata NL, Tsin AT
  Title
Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes.
  Journal
Biochim Biophys Acta 1394:16-22 (1998)
DOI:10.1016/S0005-2760(98)00078-2
Reference
5  [PMID:9920938]
  Authors
Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D
  Title
Molecular and biochemical characterization of lecithin retinol acyltransferase.
  Journal
J Biol Chem 274:3834-41 (1999)
DOI:10.1074/jbc.274.6.3834
  Sequence
[hsa:9227] [bta:281285]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.135
IUBMB Enzyme Nomenclature: 2.3.1.135
ExPASy - ENZYME nomenclature database: 2.3.1.135
BRENDA, the Enzyme Database: 2.3.1.135
CAS: 117444-03-8

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