KEGG   ENZYME: 2.3.1.136Help
Entry
EC 2.3.1.136                Enzyme                                 

Name
polysialic-acid O-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:polysialic-acid O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9 [RN:R04484 R07249]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
alpha-2,8-linked polymer of sialic acid [CPD:C04466]
Product
CoA [cpd:C00010];
polysialic acid acetylated at O-7 [CPD:C04505];
polysialic acid acetylated at O-9 [CPD:C08721]
Comment
Acts only on substrates containing more than 14 sialosyl residues. Catalyses the modification of capsular polysaccharides in some strains of Escherichia coli.
History
EC 2.3.1.136 created 1992
Orthology
K22247  polysialic-acid O-acetyltransferase
Genes
ECI: UTI89_C2635
ECV: APECO1_4217
EOC: CE10_0792(neuO)
ECOI: ECOPMV1_02507b
Taxonomy
Reference
1  [PMID:2897964]
  Authors
Higa HH, Varki A.
  Title
Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme responsible for the O-acetyl plus phenotype and for O-acetyl form variation.
  Journal
J Biol Chem 263:8872-8 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.136
IUBMB Enzyme Nomenclature: 2.3.1.136
ExPASy - ENZYME nomenclature database: 2.3.1.136
BRENDA, the Enzyme Database: 2.3.1.136
CAS: 116412-21-6

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