KEGG   ENZYME: 2.3.1.158Help
Entry
EC 2.3.1.158                Enzyme                                 

Name
phospholipid:diacylglycerol acyltransferase;
PDAT
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase
Reaction(IUBMB)
phospholipid + 1,2-diacyl-sn-glycerol = lysophospholipid + triacylglycerol [RN:R05333]
Reaction(KEGG)
Substrate
phospholipid [CPD:C00865];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
lysophospholipid [CPD:C06254];
triacylglycerol [CPD:C00422]
Comment
This enzyme differs from EC 2.3.1.20, diacylglycerol O-acyltransferase, by synthesising triacylglycerol using an acyl-CoA-independent mechanism. The specificity of the enzyme for the acyl group in the phospholipid varies with species, e.g., the enzyme from castor bean (Ricinus communis) preferentially incorporates vernoloyl (12,13-epoxyoctadec-9-enoyl) groups into triacylglycerol, whereas that from the hawk's beard (Crepis palaestina) incorporates both ricinoleoyl (12-hydroxyoctadec-9-enoyl) and vernoloyl groups. The enzyme from the yeast Saccharomyces cerevisiae specifically transfers acyl groups from the sn-2 position of the phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid.
History
EC 2.3.1.158 created 2001
Pathway
ec00561  Glycerolipid metabolism
ec01100  Metabolic pathways
Orthology
K00679  phospholipid:diacylglycerol acyltransferase
Genes
ATH: AT3G44830 AT5G13640(PDAT)
ALY: ARALYDRAFT_323168 ARALYDRAFT_488184
CRB: 17881928 17885438
CSAT: 104705618 104735371 104769582 104780334 104790735
EUS: EUTSA_v10002852mg EUTSA_v10012888mg
BRP: 103846553 103850885
BNA: 106372279 106377188 106406534 111211845
BOE: 106318490 106327439
THJ: 104799356 104809891 104814810
CPAP: 110808547 110817685 110818323
LJA: Lj3g3v2656650.1(Lj3g3v2656650.1) Lj4g3v2179270.1(Lj4g3v2179270.1)
OSA: 4347190
DOSA: Os09t0444200-01(Os09g0444200)
OBR: 102703714
BDI: 100835274
ATS: 109745768(LOC109745768)
SBI: 8081010
ZMA: 100191489(TIDP3675) 100273525(pco139319) 103633610 109944911
SITA: 101769545
PDA: 103708654
EGU: 105041806
DCT: 110096119
PEQ: 110022551
PPP: 112275614
CRE: CHLREDRAFT_186846(LCA1)
MNG: MNEG_3131
SCE: YNR008W(LRO1)
ERC: Ecym_2120
KMX: KLMA_60455(LRO1)
NCS: NCAS_0G00980(NCAS0G00980)
NDI: NDAI_0F01110(NDAI0F01110)
TPF: TPHA_0D03660(TPHA0D03660)
TBL: TBLA_0A02430(TBLA0A02430)
TDL: TDEL_0A07120(TDEL0A07120)
KAF: KAFR_0F00910(KAFR0F00910)
PIC: PICST_72946(LRO1)
CAL: CAALFM_C100870WA(LRO1)
CAUR: QG37_01035
SLB: AWJ20_3581(LRO1)
NCR: NCU02416
NTE: NEUTE1DRAFT85933(NEUTE1DRAFT_85933)
MGR: MGG_03560
SSCK: SPSK_00461
MAW: MAC_04716
MAJ: MAA_04510
CMT: CCM_01242
BFU: BCIN_02g05210(Bclro1)
MBE: MBM_06753
ANI: AN4992.2
ANG: ANI_1_1660144(An16g03640)
ABE: ARB_01216
TVE: TRV_01292
PTE: PTT_20057
SPO: SPBC776.14(plh1)
CNE: CNL04710
CNB: CNBI2140
LBC: LACBIDRAFT_156742(PDAT)
ABP: AGABI1DRAFT71227(AGABI1DRAFT_71227)
ABV: AGABI2DRAFT204119(AGABI2DRAFT_204119)
MGL: MGL_3157
EHI: EHI_099180(57.t00020)
SMIN: v1.2.037941.t1(symbB.v1.2.037941.t1)
TPS: THAPSDRAFT_261132(PDT1)
SPAR: SPRG_15381
 » show all
Taxonomy
Reference
1  [PMID:10829075]
  Authors
Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H, Stymne S.
  Title
Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants.
  Journal
Proc Natl Acad Sci U S A 97:6487-92 (2000)
DOI:10.1073/pnas.120067297
  Sequence
[sce:YNR008W]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.158
IUBMB Enzyme Nomenclature: 2.3.1.158
ExPASy - ENZYME nomenclature database: 2.3.1.158
BRENDA, the Enzyme Database: 2.3.1.158
CAS: 288587-47-3

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