KEGG   ENZYME: 2.3.1.159Help
Entry
EC 2.3.1.159                Enzyme                                 

Name
acridone synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB)
3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 [RN:R07250]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
N-methylanthraniloyl-CoA [CPD:C12092]
Product
CoA [CPD:C00010];
1,3-dihydroxy-N-methylacridone [CPD:C12093];
CO2 [CPD:C00011]
Comment
Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)
History
EC 2.3.1.159 created 2002
Pathway
ec01058  Acridone alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12644  acridone synthase
Genes
CIT: 102611283 102618836 102619137
CIC: CICLE_v10025804mg CICLE_v10025807mg
Taxonomy
Reference
1  [PMID:8148006]
  Authors
Baumert A, Maier W, Groger D, Deutzmann R.
  Title
Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L.
  Journal
Z Naturforsch [C] 49:26-32 (1994)
Reference
2
  Authors
Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Groger, D.
  Title
Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures.
  Journal
Phytochemistry 32:691-698 (1993)
Reference
3  [PMID:10217426]
  Authors
Lukacin R, Springob K, Urbanke C, Ernwein C, Schroder G, Schroder J, Matern U.
  Title
Native acridone synthases I and II from Ruta graveolens L. form homodimers.
  Journal
FEBS Lett 448:135-40 (1999)
DOI:10.1016/S0014-5793(99)00355-5
  Sequence
Reference
4  [PMID:9747538]
  Authors
Junghanns KT, Kneusel RE, Groger D, Matern U.
  Title
Differential regulation and distribution of acridone synthase in Ruta graveolens.
  Journal
Phytochemistry 49:403-11 (1998)
DOI:10.1016/S0031-9422(98)00104-6
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.159
IUBMB Enzyme Nomenclature: 2.3.1.159
ExPASy - ENZYME nomenclature database: 2.3.1.159
BRENDA, the Enzyme Database: 2.3.1.159
CAS: 99085-53-7

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