KEGG   ENZYME: 2.3.1.169Help
Entry
EC 2.3.1.169                Enzyme                                 

Name
CO-methylating acetyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:corrinoid protein O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]
Reaction(KEGG)
R08433;
(other) R09317 R10243
Show
Substrate
acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]
Product
CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]
Comment
Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.
History
EC 2.3.1.169 created 2003, modified 2015
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14138  acetyl-CoA synthase
Genes
DAK: DaAHT2_0825
DSF: UWK_03162
DOL: Dole_3184
DML: Dmul_30850(cdhC)
DAL: Dalk_0681
DAT: HRM2_16660(cdhC)
DTO: TOL2_C11810(cdhC)
DAO: Desac_1967
DTI: Desti_0231
SFU: Sfum_2565
DBR: Deba_0240
CSQ: CSCA_4551
CACE: CACET_c10320(acsB)
AMT: Amet_2028
BHAN: CGC63_07970(cdhC)
BLAU: DQQ01_09725(cdhC)
PDC: CDIF630_00844(cdhC)
DSY: DSY1652
DHD: Dhaf_2797
DAU: Daud_0871
ELM: ELI_3601
AWO: Awo_c10760(acsB1) Awo_c33680(acsB2)
CTHM: CFE_1665
TKI: TKV_c19820(acsB)
CHY: CHY_1222(acsB)
MTA: Moth_1202
ADG: Adeg_0336
TPZ: Tph_c15170(acsA)
TOC: Toce_0813
DEH: cbdbA652(codH)
DEV: DhcVS_604(cdhC)
DMC: btf_622(acsB)
DMD: dcmb_668(acsB)
DMG: GY50_0591(cdhC)
DUC: UCH007_05840(acsB)
DFO: Dform_00887(acsB) Dform_00914(acsB)
KST: KSMBR1_1325(codh_acsB)
CTHI: THC_1762
MEMA: MMAB1_3162
 » show all
Taxonomy
Reference
1  [PMID:2984190]
  Authors
Ragsdale SW, Wood HG.
  Title
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
  Journal
J Biol Chem 260:3970-7 (1985)
Reference
2  [PMID:12386327]
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL.
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science 298:567-72 (2002)
DOI:10.1126/science.1075843
  Sequence
[mta:Moth_1202]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.169
IUBMB Enzyme Nomenclature: 2.3.1.169
ExPASy - ENZYME nomenclature database: 2.3.1.169
BRENDA, the Enzyme Database: 2.3.1.169
CAS: 176591-19-8

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