KEGG   ENZYME: 2.3.1.170Help
Entry
EC 2.3.1.170                Enzyme                                 

Name
6'-deoxychalcone synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)
Reaction(IUBMB)
3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O [RN:R06568]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
CoA [CPD:C00010];
isoliquiritigenin [CPD:C08650];
CO2 [CPD:C00011];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.
History
EC 2.3.1.170 created 2004
Pathway
ec00941  Flavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:3355160]
  Authors
Ayabe S, Udagawa A, Furuya T.
  Title
NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.
  Journal
Arch Biochem Biophys 261:458-62 (1988)
DOI:10.1016/0003-9861(88)90362-1
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.170
IUBMB Enzyme Nomenclature: 2.3.1.170
ExPASy - ENZYME nomenclature database: 2.3.1.170
BRENDA, the Enzyme Database: 2.3.1.170
CAS: 114308-23-5

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