KEGG   ENZYME: 2.3.1.177Help
Entry
EC 2.3.1.177                Enzyme                                 

Name
3,5-dihydroxybiphenyl synthase;
BIS1;
biphenyl synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:benzoyl-CoA malonyltransferase
Reaction(IUBMB)
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 [RN:R09621]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
benzoyl-CoA [CPD:C00512]
Product
CoA [CPD:C00010];
3,5-dihydroxybiphenyl [CPD:C19750];
CO2 [CPD:C00011]
Comment
A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase.
History
EC 2.3.1.177 created 2006, modified 2012
Orthology
K21384  3,5-dihydroxybiphenyl/4-hydroxycoumarin synthase
Genes
FVE: 101312413
PPER: 109948444 18780920 18781256
PMUM: 103326884 103326885
PAVI: 110755238
MDM: 103407511 103418590 103424764 103455021 103456249 103456250
PXB: 103945211 103945212 103946755 103946756 103946757 103946758 103946760 103946761
Taxonomy
Reference
1  [PMID:14595561]
  Authors
Liu B, Beuerle T, Klundt T, Beerhues L.
  Title
Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia.
  Journal
Planta 218:492-6 (2004)
DOI:10.1007/s00425-003-1144-y
  Sequence
Reference
2  [PMID:17109150]
  Authors
Liu B, Raeth T, Beuerle T, Beerhues L
  Title
Biphenyl synthase, a novel type III polyketide synthase.
  Journal
Planta 225:1495-503 (2007)
DOI:10.1007/s00425-006-0435-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.177
IUBMB Enzyme Nomenclature: 2.3.1.177
ExPASy - ENZYME nomenclature database: 2.3.1.177
BRENDA, the Enzyme Database: 2.3.1.177
CAS: 1217551-24-0

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