KEGG   ENZYME: 2.3.1.187Help
Entry
EC 2.3.1.187                Enzyme                                 

Name
acetyl-S-ACP:malonate ACP transferase;
acetyl-S-ACP:malonate ACP-SH transferase;
acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase;
MdcA;
MadA;
ACP transferase;
malonate/acetyl-CoA transferase;
malonate:ACP transferase;
acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase
Reaction(IUBMB)
an acetyl-[acyl-carrier protein] + malonate = a malonyl-[acyl-carrier protein] + acetate [RN:R08944]
Reaction(KEGG)
Substrate
acetyl-[acyl-carrier protein] [CPD:C03939];
malonate [CPD:C00383]
Product
malonyl-[acyl-carrier protein] [CPD:C01209];
acetate [CPD:C00033]
Comment
This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 4.1.1.89). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].
History
EC 2.3.1.187 created 2008
Orthology
K13929  malonate decarboxylase alpha subunit
Genes
EFE: EFER_3128
SES: SARI_04157
ENT: Ent638_3779
ENC: ECL_04727
ENO: ECENHK_20525
ECLO: ENC_25620
EEC: EcWSU1_04151
ENL: A3UG_21010
ECLG: EC036_40980
ECLE: ECNIH2_21540
ECLX: LI66_20795
ECLY: LI62_22780
ECLZ: LI64_19880
ECAN: CWI88_20780(mdcA)
CTU: CTU_35070
KPN: KPN_01563
KPU: KP1_2581
KPP: A79E_2675
KPT: VK055_0939(mdcA)
KPE: KPK_2894(mdcA)
KPR: KPR_2746(mdcA)
KPJ: N559_2762
KPNU: LI86_13780
KPNK: BN49_2675(mdcA)
KVA: Kvar_2795
KOX: KOX_21640
KOE: A225_3201
EAE: EAE_18290
EAR: CCG30233
KQV: B8P98_14675(mdcA)
CKO: CKO_04769
CRO: ROD_44571(mdcA)
CAMA: F384_01165
CIE: AN232_06405(mdcA)
RAO: DSD31_11955(mdcA)
LEH: C3F35_13750(mdcA)
LNI: CWR52_14345(mdcA)
LEW: DAI21_06425(mdcA)
EBF: D782_0351
EBC: C2U52_10415(mdcA)
SMAF: D781_3744
SERA: Ser39006_012630(mdcA)
SERM: CLM71_19535(mdcA)
RAA: Q7S_01145
DDQ: DDI_1346
DFN: CVE23_08790(mdcA)
EPE: CI789_21985(mdcA)
PVA: Pvag_2968(mdcA)
PAGG: AL522_21990(mdcA)
PGZ: C2E15_17670(mdcA)
PCD: C2E16_17650(mdcA)
XCC: XCC3609(mdcA)
XCB: XC_0572
XCP: XCR_3944
XCV: XCV0594(mdcA)
XAX: XACM_0551(mdcA)
XAC: XAC0560(mdcA)
XCI: XCAW_00974(mdcA)
XFU: XFF4834R_chr05560(mdcA)
XPH: XppCFBP6546_08930(XppCFBP6546P_08930)
XVA: C7V42_02930(mdcA)
SML: Smlt1232
SMT: Smal_1081
SMZ: SMD_1153
STEN: CCR98_05750(mdcA)
STEM: CLM74_05760(mdcA)
PAE: PA0208(mdcA)
PAEV: N297_214(mdcA)
PAEI: N296_214(mdcA)
PAU: PA14_02550(mdcA)
PAP: PSPA7_0292(mdcA)
PAG: PLES_02031(mdcA)
PAF: PAM18_0203(mdcA)
PNC: NCGM2_0212(mdcA)
PAEB: NCGM1900_0197(mdcA)
PAEP: PA1S_01075
PAEM: U769_01035
PAEL: T223_01025
PAEU: BN889_00257(mdcA)
PAEG: AI22_02870
PAEC: M802_213(mdcA)
PAEO: M801_214(mdcA)
PMK: MDS_0234
PRE: PCA10_01810(mdcA)
PPT: PPS_2975
PPUH: B479_14790
PPUT: L483_18335
PPUN: PP4_23620(mdcA)
PPUD: DW66_3238
PMON: X969_14245
PMOT: X970_13890
PST: PSPTO_5087(mdcA)
PSB: Psyr_0442
PSYR: N018_02115
PSP: PSPPH_0433(mdcA)
PAMG: BKM19_003785(mdcA)
PAVL: BKM03_26770(mdcA)
PFL: PFL_5820(mdcA)
PPRC: PFLCHA0_c57750(mdcA)
PPRO: PPC_5767(mdcA)
PFS: PFLU_5743
PFE: PSF113_5521(mdcA)
PFC: PflA506_5042(mdcA)
PFW: PF1751_v1c51650(mdcA)
PFB: VO64_2626
PSA: PST_4120(mdcA)
PSZ: PSTAB_4102(mdcA)
PSR: PSTAA_4272(mdcA)
PSTT: CH92_21570
PPUU: PputUW4_05099(mdcA)
PSES: PSCI_2021(mdcA)
PSEM: TO66_29440
PSOS: POS17_5757(mdcA)
PANR: A7J50_5473
PSET: THL1_155
PSIL: PMA3_28350
AVN: Avin_10280(mdcA)
AVL: AvCA_10280(mdcA)
AVD: AvCA6_10280(mdcA)
ACX: Achr_31830(mdcA)
PAR: Psyc_1146(mdcA)
PALI: A3K91_1692
ACB: A1S_1421
ABY: ABAYE2233(mdcA)
ABN: AB57_1654
ABB: ABBFA_002066(mdcA)
ABX: ABK1_1914
ABZ: ABZJ_01622(mdcA)
ABH: M3Q_1816
ABAD: ABD1_14220(mdcA)
ABAZ: P795_10095
ABAU: IX87_03125
ABAA: IX88_09070
ACI: ACIAD1753(mdcA)
ARJ: DOM24_08315(mdcA)
PIN: Ping_3659
LPN: lpg2426(mdcA)
LPH: LPV_2747(mdcA)
LPO: LPO_2616(mdcA)
LPM: LP6_2454(mdcA)
LPP: lpp2493
LPC: LPC_2050(mdcA)
LPA: lpa_03539
LPE: lp12_2418
LLO: LLO_2547(mdcA)
LFA: LFA_0132(madA)
LOK: Loa_02051
LSH: CAB17_18045(mdcA)
TMC: LMI_1326
SALN: SALB1_2476
NBA: CUN60_06690(mdcA)
PSE: NH8B_2978(mdcA)
RSC: RCFBP_11827(mdcA)
RPI: Rpic_4939
RIN: ACS15_5430(mdcA)
CNC: CNE_1c16450(mdcA)
BMA: BMA3037(mdcA)
BMAL: DM55_2718(mdcA)
BMAE: DM78_2266(mdcA)
BMAQ: DM76_2702(mdcA)
BMAI: DM57_2815
BMAF: DM51_2641(mdcA)
BMAZ: BM44_2491(mdcA)
BMAB: BM45_2056(mdcA)
BPS: BPSL1329
BPM: BURPS1710b_1582(mdcA)
BPL: BURPS1106A_1482(mdcA)
BPD: BURPS668_1452(mdcA)
BPR: GBP346_A1485(mdcA)
BPSE: BDL_687(mdcA)
BPSM: BBQ_2114(mdcA)
BPSU: BBN_2240(mdcA)
BPSD: BBX_2628(mdcA)
BPK: BBK_191(mdcA)
BPSH: DR55_3269(mdcA)
BPSA: BBU_864(mdcA)
BPSO: X996_2876(mdcA)
BUT: X994_1336(mdcA)
BTE: BTH_I2803
BTQ: BTQ_1216(mdcA)
BTJ: BTJ_1217(mdcA)
BTZ: BTL_2452(mdcA)
BTD: BTI_2501(mdcA)
BTV: BTHA_2638(mdcA)
BTHE: BTN_2206(mdcA)
BTHM: BTRA_2809(mdcA)
BTHA: DR62_2441
BTHL: BG87_2700(mdcA)
BOK: DM82_771(mdcA)
BOC: BG90_246(mdcA)
BVE: AK36_2679(mdcA)
BCN: Bcen_0788
BCJ: BCAL1240
BCEN: DM39_1147(mdcA)
BCEW: DM40_1923(mdcA)
BCEO: I35_1153
BAM: Bamb_1147
BMU: Bmul_2050
BMJ: BMULJ_01194(mdcA)
BMK: DM80_383(mdcA)
BMUL: NP80_1357(mdcA)
BCT: GEM_2186
BCED: DM42_451(mdcA)
BDL: AK34_1898(mdcA)
BCON: NL30_09315
BUB: BW23_470(mdcA)
BLAT: WK25_06340
BTEI: WS51_16685
BSEM: WJ12_06235
BPSL: WS57_24065
BMEC: WJ16_06010
BSTG: WT74_06530
BGU: KS03_2050(mdcA)
BGO: BM43_2649(mdcA)
BUK: MYA_1147
BUL: BW21_2517(mdcA)
BGP: BGL_1c12070(mdcA)
BXE: Bxe_B1844
BXB: DR64_7151(mdcA)
BPH: Bphy_5087
BFN: OI25_4296(mdcA)
PARB: CJU94_20515(mdcA) CJU94_21940(mdcA)
PHS: C2L64_21225(mdcA) C2L64_27620(mdcA)
PTER: C2L65_20880(mdcA) C2L65_44085(mdcA)
PGP: CUJ91_26020(mdcA)
PLG: NCTC10937_05023(mdcA)
AMIM: MIM_c07980(mdcA)
AFQ: AFA_04500(mdcA)
ODI: ODI_R0980
RFR: Rfer_1843
PNA: Pnap_0946
VEI: Veis_2896
DAC: Daci_1768
MPT: Mpe_A2895
HAR: HEAR1469(mdcA)
MMS: mma_0104(mdcA1) mma_2563(mdcA2)
JAG: GJA_2737(mdcA)
HSE: Hsero_2683(mdcA)
HRB: Hrubri_2770(mdcA)
HEE: hmeg3_12690(mdcA)
CFU: CFU_1708(mdcA)
CARE: LT85_3021
CPRA: CPter91_2199(mdcA)
MASS: CR152_24325(mdcA)
MTIM: DIR46_04305(mdcA)
OFO: BRW83_1388(madA)
LCH: Lcho_0079
DAR: Daro_4020
AZA: AZKH_1590(mdcA)
ATW: C0099_10775(mdcA) C0099_15070(mdcA)
CCRO: CMC5_081220(mdcA)
BJA: bll0270(mdcA)
BRS: S23_13470(mdcA)
RPB: RPB_3298
OCA: OCAR_6872(mdcA)
SNO: Snov_1207
MEX: Mext_0024
MEA: Mex_1p0023(mdcA)
MDI: METDI0024(mdcA)
MCH: Mchl_0025
MPO: Mpop_0046
MET: M446_6857
MNO: Mnod_3151
MOR: MOC_0174(mdcA)
META: Y590_00160
MEE: DA075_34085(mdcA)
METD: C0214_00165(mdcA)
MSL: Msil_3192
HDI: HDIA_0491
RCP: RCAP_rcp00130(mdcA)
SWI: Swit_4286
STAX: MC45_04590
ROS: CTJ15_14390(mdcA)
RRU: Rru_A1322
RRF: F11_06840
NAO: Y958_23565(mdcA)
BPF: BpOF4_11970(mdcA)
BMQ: BMQ_0796(mdcA)
BMD: BMD_0797(mdcA)
BMH: BMWSH_4450(mdcA)
BMEG: BG04_3091(mdcA)
BEO: BEH_05650
BKW: BkAM31D_07960(madA)
PPOL: X809_35675
SIV: SSIL_3617(mdcA)
LCR: LCRIS_01571(mdcA)
EFU: HMPREF0351_10353(mdcA)
EFM: M7W_524
ECAS: ECBG_00927
EDU: LIU_13410
EGA: AL523_13890(mdcA)
PFT: JBW_01390
 » show all
Taxonomy
Reference
1  [PMID:18251085]
  Authors
Hilbi H, Dimroth P
  Title
Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase.
  Journal
Arch Microbiol 162:48-56 (1994)
  Sequence
Reference
2  [PMID:9208947]
  Authors
Hoenke S, Schmid M, Dimroth P
  Title
Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli.
  Journal
Eur J Biochem 246:530-8 (1997)
DOI:10.1111/j.1432-1033.1997.00530.x
  Sequence
Reference
3  [PMID:10561613]
  Authors
Koo JH, Kim YS
  Title
Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus.
  Journal
Eur J Biochem 266:683-90 (1999)
DOI:10.1046/j.1432-1327.1999.00924.x
Reference
4  [PMID:12619701]
  Authors
Chohnan S, Akagi K, Takamura Y
  Title
Functions of malonate decarboxylase subunits from Pseudomonas putida.
  Journal
Biosci Biotechnol Biochem 67:214-7 (2003)
DOI:10.1271/bbb.67.214
Reference
5  [PMID:11902724]
  Authors
Dimroth P, Hilbi H
  Title
Enzymic and genetic basis for bacterial growth on malonate.
  Journal
Mol Microbiol 25:3-10 (1997)
DOI:10.1046/j.1365-2958.1997.4611824.x
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.187
IUBMB Enzyme Nomenclature: 2.3.1.187
ExPASy - ENZYME nomenclature database: 2.3.1.187
BRENDA, the Enzyme Database: 2.3.1.187

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