KEGG   ENZYME: 2.3.1.194Help
Entry
EC 2.3.1.194                Enzyme                                 

Name
acetoacetyl-CoA synthase;
NphT7
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating)
Reaction(IUBMB)
acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2 [RN:R09527]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083]
Product
acetoacetyl-CoA [CPD:C00332];
CoA [CPD:C00010];
CO2 [CPD:C00011]
Comment
The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway.
Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.
History
EC 2.3.1.194 created 2011
Orthology
K21378  acetoacetyl-CoA synthase
Genes
MUL: MUL_3531(fabH_1)
MMI: MMAR_3221(fabH_1)
MLI: MULP_03448(fabH_1)
NBR: O3I_033200
SVL: Strvi_3790
SCT: SCAT_p1096
SCY: SCATT_p06400
SBH: SBI_01378
SDV: BN159_7956(fabH5)
SALS: SLNWT_0281
SGU: SGLAU_17330(nphT7)
STRM: M444_04515
KSK: KSE_59090(fabH4)
NDA: Ndas_3368
ACTN: L083_4421
AFS: AFR_19640
 » show all
Taxonomy
Reference
1  [PMID:20534558]
  Authors
Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T
  Title
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.
  Journal
Proc Natl Acad Sci U S A 107:11265-70 (2010)
DOI:10.1073/pnas.1000532107
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.194
IUBMB Enzyme Nomenclature: 2.3.1.194
ExPASy - ENZYME nomenclature database: 2.3.1.194
BRENDA, the Enzyme Database: 2.3.1.194

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