KEGG   ENZYME: 2.3.1.20Help
Entry
EC 2.3.1.20                 Enzyme                                 

Name
diacylglycerol O-acyltransferase;
diglyceride acyltransferase;
1,2-diacylglycerol acyltransferase;
diacylglycerol acyltransferase;
diglyceride O-acyltransferase;
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase;
acyl-CoA:1,2-diacylglycerol O-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol [RN:R02251]
Reaction(KEGG)
R02251 > R02694;
(other) R09474
Show
Substrate
acyl-CoA [CPD:C00040];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CoA [CPD:C00010];
triacylglycerol [CPD:C00422]
Comment
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
History
EC 2.3.1.20 created 1965
Pathway
ec00073  Cutin, suberine and wax biosynthesis
ec00561  Glycerolipid metabolism
ec01100  Metabolic pathways
Orthology
K00635  diacylglycerol O-acyltransferase / wax synthase
K11155  diacylglycerol O-acyltransferase 1
K11160  diacylglycerol O-acyltransferase 2
K14456  2-acylglycerol O-acyltransferase 3
K15406  wax-ester synthase / diacylglycerol O-acyltransferase
K18851  diacylglycerol O-acyltransferase / trehalose O-mycolyltransferase
K22848  diacylglycerol O-acyltransferase 2, plant
K22849  diacylglycerol O-acyltransferase 3, plant
Genes
HSA: 346606(MOGAT3) 84649(DGAT2) 8694(DGAT1)
PTR: 464460(DGAT1) 466714(DGAT2) 472468(MOGAT3)
PPS: 100969446(MOGAT3) 100987880(DGAT2) 100994391(DGAT1)
GGO: 101124779(DGAT2) 101142898(DGAT1) 101150469(MOGAT3)
PON: 100439588(MOGAT3) 100442216(DGAT2) 100453587(DGAT1)
NLE: 100590733(DGAT1) 100596253(MOGAT3) 100596453(DGAT2)
MCC: 696549(DGAT2) 701489(DGAT1) 714110(MOGAT3)
MCF: 102116598(MOGAT3) 102121566(DGAT1) 102128601(DGAT2)
CSAB: 103237618(DGAT1) 103246692(MOGAT3) 103248066(DGAT2)
RRO: 104665097(DGAT2) 104671680(DGAT1) 104681186(MOGAT3)
RBB: 108518949(MOGAT3) 108536546(DGAT1) 108545121(DGAT2)
CJC: 100402659(DGAT1) 100414192(DGAT2) 100415057(MOGAT3)
SBQ: 101041407(DGAT1) 101044301(MOGAT3) 101049433(DGAT2)
MMU: 13350(Dgat1) 67800(Dgat2)
RNO: 252900(Dgat2) 84497(Dgat1)
CGE: 100755985(Dgat1) 100769277(Mogat3) 100774981(Dgat2)
NGI: 103733547(Mogat3) 103735255(Dgat1) 103743019(Dgat2)
HGL: 101698712(Dgat2) 101723650(Dgat1) 106008984(Mogat3)
CCAN: 109680743(Dgat2) 109691174(Dgat1)
TUP: 102471587(MOGAT3) 102474487(DGAT1) 102494423(DGAT2)
CFA: 482093(DGAT1) 485185(DGAT2) 608245(MOGAT3)
AML: 100468811(DGAT2) 100479095(DGAT1) 100484228(MOGAT3)
UMR: 103656696(DGAT1) 103670128(MOGAT3) 103678126(DGAT2)
ORO: 101366779(DGAT1) 101380300(MOGAT3) 101385232(DGAT2)
FCA: 101089413(MOGAT3) 101100329(DGAT2) 101101615(DGAT1)
PTG: 102952153(DGAT2) 102952284(DGAT1) 102971732(MOGAT3)
AJU: 106976464(DGAT2) 106979135(DGAT1) 106988105(MOGAT3)
BTA: 282609(DGAT1) 404129(DGAT2) 618076
BIU: 109569733(DGAT2) 109578860
PHD: 102324317(MOGAT3) 102333981(DGAT1) 102341303
SSC: 100294675(DGAT2) 100624333 397118(DGAT1)
CFR: 102504113(DGAT2) 102515256(DGAT1) 102519554(MOGAT3)
CDK: 105092399(MOGAT3) 105097240(DGAT2) 105104999(DGAT1)
BACU: 103001320(DGAT1) 103018277(DGAT2) 103018879(MOGAT3)
LVE: 103073062(DGAT1) 103075069(DGAT2)
OOR: 101275488(DGAT1) 101278069(MOGAT3) 101283358(DGAT2)
ECB: 100060232(MOGAT3) 100064387(DGAT2) 100147359(DGAT1)
EPZ: 103540220(DGAT1) 103545802 103548227(DGAT2) 103566972(MOGAT3)
EAI: 106839343(MOGAT3) 106840399(DGAT2) 106841896(DGAT1)
MYB: 102249216 102249575(MOGAT3) 102261774(DGAT2) 102263903(DGAT1)
MYD: 102753473(DGAT2) 102755787(MOGAT3) 102769363(DGAT1)
HAI: 109375066(DGAT1) 109385008(MOGAT3) 109386362(DGAT2)
RSS: 109435253(DGAT1) 109441591 109444790(DGAT2) 109458775(MOGAT3)
PALE: 102881221(MOGAT3) 102889573(DGAT1) 102898739(DGAT2)
MDO: 100011089(DGAT2) 100017805(MOGAT3) 100018271(DGAT1)
SHR: 100914285(DGAT2) 100922391(MOGAT3) 100924635(DGAT1)
OAA: 100088895(DGAT2) 100089507(MOGAT3) 103166832(DGAT1)
GGA: 421309(DGAT2) 428693(AWAT1)
MGP: 100540643 100545351(DGAT2)
CJO: 107308594(DGAT2) 107312638
APLA: 101792641 101801215(DGAT2)
ACYG: 106042403(DGAT2) 106042952
TGU: 100220095(DGAT2)
GFR: 102035873(DGAT2) 102037230
FAB: 101810713(DGAT2) 101820931
PHI: 102100921 102107779(DGAT2)
PMAJ: 107204039 107211569(DGAT2)
CCW: 104686963(DGAT2) 104691343
FPG: 101917877 101924658(DGAT2) 106112364(DGAT1)
FCH: 102055207(DGAT2) 102057990 106631435(DGAT1)
CLV: 102085339 102087439(DGAT2)
EGZ: 104124768(DGAT2) 104135988
AMJ: 102557932(DGAT2) 102562878(MOGAT3) 102576196(DGAT1) 102576534(AWAT2)
PSS: 102443911(MOGAT3) 102448420(DGAT1) 102449336 102453357(DGAT2)
CPIC: 101930999(DGAT2) 101938904(MOGAT3) 101950557 101950960(DGAT1) 101951746
ACS: 100551857(dgat1) 100552736(dgat2) 100555636
PVT: 110074308 110077436(MOGAT3) 110084814(DGAT1) 110087798(DGAT2)
PBI: 103052621(DGAT2) 103062413 103065772(DGAT1)
GJA: 107110553 107110672(DGAT1) 107112091(DGAT2)
XLA: 100126612(awat1.L) 100127341 100381012(dgat1.L) 108698316(dgat2l6.L) 108710042(dgat2.S) 108710383(mogat3.L) 398800(dgat2.L)
XTR: 100127622(awat1) 100127752(dgat2l6) 100491581(mogat3) 101730812(dgat1) 395003(dgat2)
DRE: 325875(dgat1a) 565316(dgat2)
PRET: 103472475(dgat1) 103475773 103476122(dgat2) 103478641
LCM: 102349959(DGAT1) 102351093(DGAT2) 102358735 102359647(MOGAT3) 102360601
CIN: 100177672
SPU: 575003
APLC: 110982992
SKO: 100376218
DME: Dmel_CG31991(mdy)
DSI: Dsimw501_GD24087(Dsim_GD24087)
MDE: 101894841
AAG: 5569069
AME: 552377
BIM: 100744121
BTER: 100646196
SOC: 105194711
AEC: 105151363
ACEP: 105618616
PBAR: 105422883
HST: 105182283
CFO: 105253928
LHU: 105676355
PGC: 109852637
NVI: 100116518
TCA: 664028
DPA: 109533688
NVL: 108568180
BMOR: 101742497
PMAC: 106710683
PRAP: 110991401
FCD: 110852290
TUT: 107362581
CEL: CELE_H19N07.4(mboa-2)
CBR: CBG23107
BMY: Bm1_52020
TSP: Tsp_02502
CRG: 105331361
MYI: 110442476
OBI: 106869194
LAK: 106165236
SHX: MS3_08893
EGL: EGR_02006
EPA: 110238682
ADF: 107351603
HMG: 101238034
ATH: AT1G48300(DGAT3) AT2G19450(TAG1) AT3G51520(DGAT2) AT5G37300(WSD1)
LJA: Lj0g3v0265219.1(Lj0g3v0265219.1) Lj2g3v1573080.1(Lj2g3v1573080.1) Lj2g3v1573080.2(Lj2g3v1573080.2) Lj4g3v2172770.1(Lj4g3v2172770.1) Lj4g3v2172770.2(Lj4g3v2172770.2) Lj4g3v2225710.1(Lj4g3v2225710.1) Lj6g3v1226310.1(Lj6g3v1226310.1)
JCU: 105637897(DGAT1) 105642702 105646335(DGAT2)
DOSA: Os02t0714100-01(Os02g0714100) Os05t0137300-01(Os05g0137300) Os05t0196800-00(Os05g0196800) Os06t0326700-01(Os06g0326700) Os06t0563900-01(Os06g0563900)
ATS: 109752785(LOC109752785) 109759239 109763503(LOC109763503) 109765064(LOC109765064) 109767234(LOC109767234) 109770244(LOC109770244)
ZMA: 100217122(cl28396_1a) 100276511 100283803 100383910 103629820(DGAT1-2)
SLB: AWJ20_4739(ARE2)
NCR: NCU00035
NTE: NEUTE1DRAFT129602(NEUTE1DRAFT_129602)
MGR: MGG_05326
SSCK: SPSK_02335
MAW: MAC_07178
MAJ: MAA_07086
CMT: CCM_05029
MBE: MBM_00351
ANI: AN6159.2
ANG: ANI_1_1688104(An12g03600)
ABE: ARB_04951
TVE: TRV_06710
PTE: PTT_18543
DDI: DDB_G0271342(dgat1)
PYO: PY17X_1219400(PY01256)
PCB: PCHAS_121690(PC301445.00.0)
TAN: TA19620
TPV: TP01_0247
BBO: BBOV_IV004970(23.m06462)
CPV: cgd2_1090
PSHI: SAMEA2665130_1588(tgs2)
PCQ: PcP3B5_33150(wax-dgaT)
PAR: Psyc_0223
PALI: A3K91_0285
PSYA: AOT82_1515
ACB: A1S_2776
ABM: ABSDF0686(wax-dgaT)
ABY: ABAYE0708(wax-dgaT)
ABN: AB57_3277
ABX: ABK1_3078
ABH: M3Q_3256
ABAD: ABD1_27220(wax-dgaT)
ABAZ: P795_3265
ABAU: IX87_10725
ABAA: IX88_17050
ACI: ACIAD0832(wax-dgaT)
MCT: MCR_1402
MCS: DR90_526(wax-dgaT)
MCAT: MC25239_01357(wax-dgaT)
MHC: MARHY0163(wax-dgaT) MARHY0721 MARHY3006
AMAL: I607_12125
AMAE: I876_12500
AMAO: I634_12355
AMAD: I636_12495
AMAI: I635_12860
AMAG: I533_12105
AMAC: MASE_11900
AAUS: EP12_12730
ASP: AOR13_989
GNI: GNIT_1288
HCH: HCH_05018
ABO: ABO_2742(atfA1)
ADI: B5T_04434(atfA1)
APAC: S7S_18395
AXE: P40_21630
RGE: RGE_07320
BRS: S23_51360
BRAD: BF49_1814
SGI: SGRAN_3397(atfA)
SSAN: NX02_21015
BLAS: BSY18_1483
MLE: ML0097(fbpA) ML1244 ML2028(fbpB) ML2655(fbpC2)
MLB: MLBr00097(fbpA) MLBr01244 MLBr02028(fbpB) MLBr02655(fbpC2)
MTHN: 4412656_00222(wax-dgaT) 4412656_00271(tgs1) 4412656_00813(tgs2_1) 4412656_01213(tgs3) 4412656_01363(fbpB) 4412656_01808(tgs2_2) 4412656_02288(fbpC_2) 4412656_02315(fbpC_3) 4412656_02948(tgs4_1) 4412656_03292(tgs4_2) 4412656_03604(fbpC_4) 4412656_03900(tgs2_3) 4412656_04405(fbpC_5) 4412656_04406(fbpA_2)
MTER: 4434518_00171(wax-dgaT_1) 4434518_01314(wax-dgaT_2) 4434518_01923(fbpB_1) 4434518_02445(tgs1_1) 4434518_02908(tgs3) 4434518_02970(tgs1_2) 4434518_03072(fbpB_2) 4434518_03621(wax-dgaT_3) 4434518_03975(tgs2) 4434518_04061(fbpA) 4434518_04119(fbpC)
CRD: CRES_0530(cmtB)
CTER: A606_00990
CSX: CSING_12345(cmtB)
CPHO: CPHO_11460
CAMG: CAMM_11865
CMIN: NCTC10288_00193(cmtB)
RFA: A3L23_00029(tgs3) A3L23_00541(tgs2) A3L23_02025(fbpB_1) A3L23_02026(fbpB_2)
RHS: A3Q41_01337(fbpB_3) A3Q41_01338(fbpB_4) A3Q41_02812(tgs2) A3Q41_03384(tgs3)
SRT: Srot_2698
SCO: SCO0123(SCJ21.04c) SCO0958(SCM11.13c) SCO1280(2SCG18.27c)
SMA: SAVERM_7256(tgs)
SGR: SGR_725
SGB: WQO_31540
SFA: Sfla_0439
SBH: SBI_10013
SHY: SHJG_7843
STRP: F750_6559
SFI: SFUL_6709
SLD: T261_0684
STRM: M444_06555
SPRI: SPRI_6803
SRW: TUE45_00141(tgs1)
SLE: sle_07290(sle_07290) sle_59870(sle_59870)
SMAL: SMALA_6742
SFK: KY5_7376
KSK: KSE_72050
CFI: Celf_3117
TCU: Tcur_0504
FAL: FRAAL4187
MMAR: MODMU_4673
SEN: SACE_6439
PDX: Psed_5172
AMI: Amir_6300
KAL: KALB_7880
ACTI: UA75_27080
ACAD: UA74_26495
AHG: AHOG_24410(tgs3)
CWO: Cwoe_1834
 » show all
Taxonomy
Reference
1  [PMID:947894]
  Authors
Coleman R, Bell RM.
  Title
Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols.
  Journal
J Biol Chem 251:4537-43 (1976)
Reference
2  [PMID:6289909]
  Authors
Grigor MR, Bell RM.
  Title
Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.
  Journal
Biochim Biophys Acta 712:464-72 (1982)
DOI:10.1016/0005-2760(82)90273-9
Reference
3  [PMID:3422635]
  Authors
Kawasaki T, Snyder F.
  Title
Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells.
  Journal
J Biol Chem 263:2593-6 (1988)
Reference
4  [PMID:13843753]
  Authors
WEISS SB, KENNEDY EP, KIYASU JY.
  Title
The enzymatic synthesis of triglycerides.
  Journal
J Biol Chem 235:40-4 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.20
IUBMB Enzyme Nomenclature: 2.3.1.20
ExPASy - ENZYME nomenclature database: 2.3.1.20
BRENDA, the Enzyme Database: 2.3.1.20
CAS: 9029-98-5

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