KEGG   ENZYME: 2.3.1.200Help
Entry
EC 2.3.1.200                Enzyme                                 

Name
lipoyl amidotransferase;
LipL (gene name, ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
[glycine cleavage system H]-N6-lipoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine lipoyltransferase
Reaction(IUBMB)
[glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine
Substrate
[glycine cleavage system H]-N6-lipoyl-L-lysine;
[lipoyl-carrier protein]
Product
glycine cleavage system H;
[lipoyl-carrier protein]-N6-lipoyl-L-lysine
Comment
In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid. The enzyme is bound to 2-oxo-acid dehydrogenases such as the pyruvate dehydrogenase complex, where it transfers the lipoyl moiety from lipoyl-[glycine cleavage system H] to the E2 subunits of the complexes.
History
EC 2.3.1.200 created 2012
Orthology
K18821  lipoyl amidotransferase
Genes
VIR: X953_17535
VHL: BME96_17025
VPN: A21D_00984(lipL)
LMO: lmo2566
LMN: LM5578_2761
LMY: LM5923_2710
LMT: LMRG_02703
LMOC: LMOSLCC5850_2570
LMOE: BN418_3034
LMOB: BN419_3048
LMOD: LMON_2581
LMOW: AX10_06905
LMOQ: LM6179_1634(lipL)
LMR: LMR479A_2694(lipL)
LMOM: IJ09_11965
LMOG: BN389_25270(lipL)
LMP: MUO_12810
LMOX: AX24_10790
LMQ: LMM7_2609
LMS: LMLG_2526
LMOK: CQ02_13025
LIN: lin2711
LWE: lwe2516(lplA)
LSG: lse_2473
LIV: LIV_2479
 » show all
Taxonomy
Reference
1  [PMID:21768091]
  Authors
Christensen QH, Hagar JA, O'Riordan MX, Cronan JE
  Title
A complex lipoate utilization pathway in Listeria monocytogenes.
  Journal
J Biol Chem 286:31447-56 (2011)
DOI:10.1074/jbc.M111.273607
  Sequence
[lmo:lmo2566]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.200
IUBMB Enzyme Nomenclature: 2.3.1.200
ExPASy - ENZYME nomenclature database: 2.3.1.200
BRENDA, the Enzyme Database: 2.3.1.200

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