KEGG   ENZYME: 2.3.1.201Help
Entry
EC 2.3.1.201                Enzyme                                 

Name
UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase;
WbpD;
WlbB
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [RN:R10100]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD:C20359]
Product
CoA [CPD:C00010];
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.
History
EC 2.3.1.201 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K13018  UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
Genes
PLU: plu4798(wblC)
PLUM: A4R40_23865
PAY: PAU_04313(wblC)
PTT: VY86_07525
XBO: XBJ1_4315
XNE: XNC1_0113
XNM: XNC2_0115
MSU: MS1499(wbbJ)
ASU: Asuc_0109
AAZ: ADJ80_05780
PAE: PA3156(wbpD)
PAEV: N297_3267(wlbB)
PAEI: N296_3267(wlbB)
PAEC: M802_3265(wlbB)
PAEO: M801_3132(wlbB)
PMY: Pmen_1859
PPUH: B479_06910
PSES: PSCI_2867
PSOS: POS17_4988
PSET: THL1_1978
PALI: A3K91_0720
ACB: A1S_0054
ACC: BDGL_002973(wbpD)
SAZ: Sama_2258
SSE: Ssed_2971
PSEO: OM33_04955
LFA: LFA_0789(wbpD)
LOK: Loa_02106
TNI: TVNIR_0689(dapH_[H])
ADI: B5T_01709(wbbJ)
CVI: CV_4125
PSE: NH8B_0415
REH: H16_B0032(wbpD)
PPNO: DA70_17275
BPE: BP0092(bplB)
BPC: BPTD_0088(bplB)
BPER: BN118_0161(wlbB)
BPET: B1917_0095(bplB)
BPEU: Q425_2050(bplB)
BPA: BPP0154(bplB)
BPAR: BN117_0152(wlbB)
BBR: BB0154(bplB)
BBM: BN115_0143(wlbB)
BBH: BN112_3257(wlbB)
BBX: BBS798_0153(bplB)
BPT: Bpet4817(wlbB)
BAV: BAV0097(wlbB)
BHO: D560_1329(wlbB)
BHM: D558_1318(wlbB)
BHZ: ACR54_00109(wbpD_1)
BTRM: SAMEA390648701341(bplB)
AXX: ERS451415_06024(dapH)
TEA: KUI_0408
TEG: KUK_0146
ODI: ODI_R2825
PNA: Pnap_3128
AAV: Aave_0951
AJS: Ajs_3016
CTES: O987_08015
HYB: Q5W_21480
LCH: Lcho_0290
RGE: RGE_41560(wbpD)
HMS: HMU06620
HCP: HCN_0855
WSU: WS2187(WBPD)
GEB: GM18_1434
LIR: LAW_30092
DOL: Dole_1820
HOH: Hoch_6855
DBR: Deba_2421
BBAC: EP01_04560
RBS: RHODOSMS8_00381(wbpD)
SPHU: SPPYR_1649(wbpD)
MAI: MICA_316(wlbB)
CBZ: Cbs_4881
CBEI: LF65_05486
CSR: Cspa_c55380(wbpD)
CSB: CLSA_c43280(wbpD)
ELM: ELI_2559
SYNW: SynWH8103_00501(wlbB)
HHG: XM38_017740(glmU_2)
GLJ: GKIL_0480(wbpD)
CALH: IJ00_16860
RCA: Rcas_0783
PUV: PUV_00140
PBAS: SMSP2_01882(wbpD)
TPED: TPE_0188
TLI: Tlie_1825
GAU: GAU_1967
GBA: J421_2474
PDI: BDI_2184
TFO: BFO_1995
BLQ: L21SP5_01620(wbpD)
RMR: Rmar_1673
SGN: SGRA_0090
HSW: Hsw_0077
ZGA: ZOBELLIA_1738(fdtC)
TJE: TJEJU_1134(wbpD)
TMAR: MARIT_2955(wbpD)
SPON: HME9304_01539(wbpD)
IAL: IALB_2461(wbpD)
MRO: MROS_2686
CABY: Cabys_3435
DTU: Dtur_0577
 » show all
Taxonomy
Reference
1  [PMID:19282284]
  Authors
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS
  Title
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the  biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas  aeruginosa.
  Journal
J Biol Chem 284:11854-62 (2009)
DOI:10.1074/jbc.M808583200
  Sequence
[pae:PA3156]
Reference
2  [PMID:19348502]
  Authors
Larkin A, Imperiali B
  Title
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
  Journal
Biochemistry 48:5446-55 (2009)
DOI:10.1021/bi900186u
  Sequence
[pae:PA3156]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.201
IUBMB Enzyme Nomenclature: 2.3.1.201
ExPASy - ENZYME nomenclature database: 2.3.1.201
BRENDA, the Enzyme Database: 2.3.1.201

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