KEGG   ENZYME: 2.3.1.203Help
Entry
EC 2.3.1.203                Enzyme                                 

Name
UDP-N-acetylbacillosamine N-acetyltransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase;
pglD (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + UDP-N-acetylbacillosamine = CoA + UDP-N,N'-diacetylbacillosamine [RN:R10099]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
UDP-N-acetylbacillosamine [CPD:C04630]
Product
CoA [CPD:C00010];
UDP-N,N'-diacetylbacillosamine [CPD:C20357]
Comment
The product, UDP-N,N'-diacetylbacillosamine, is an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [1,2] and O-linked glycosylation of certain L-serine residues in Neisseria species [3].
History
EC 2.3.1.203 created 2012, modified 2013
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K15913  UDP-N-acetylbacillosamine N-acetyltransferase
Genes
SKU: Sulku_2411
CJE: Cj1123c(pglD)
CJB: BN148_1123c(pglD)
CJJ: CJJ81176_1140(pglD)
CJU: C8J_1063(pglD)
CJN: ICDCCJ07001_1078
CJI: CJSA_1065(pglD)
CJM: CJM1_1101(pglD)
CJS: CJS3_1169
CJP: A911_05440
CJEJ: N564_01091
CJEU: N565_01134
CJEN: N755_01127
CJEI: N135_01160
CJER: H730_06585
CJV: MTVDSCj20_1126(pglD)
CJY: QZ67_01200(pglD)
CJQ: UC78_1080(pglD)
CJR: CJE1265(pglD)
CJD: JJD26997_0598(pglD)
CFT: CFF04554_1395(pglD)
CFV: CFVI03293_1418(pglD)
CFX: CFV97608_1518(pglD)
CFZ: CSG_15170
CAMP: CFT03427_1343(pglD)
CCV: CCV52592_1210(pglD)
CCO: CCC13826_0449(pglD)
CCOC: CCON33237_1462(pglD)
CLA: Cla_1256(pglD)
CLR: UPTC16701_1239(pglD)
CLM: UPTC16712_1257(pglD)
CLQ: UPTC4110_1241(pglD)
CLN: UPTC3659_1476(pglD)
CLL: CONCH_1207(pglD)
CCQ: N149_1064
CCF: YSQ_03355
CCY: YSS_06080
CCOI: YSU_03390
CCOF: VC76_05510(pglD)
CCOO: ATE51_00920(pglD_1) ATE51_01358(pglD_3)
CAJ: CIG1485E_1389(pglD)
CIS: CINS_1221(pglD)
CVO: CVOL_1235(pglD)
CPEL: CPEL_1362(pglD)
CAMR: CAQ16704_1267(pglD)
CSM: CSUB8521_1443(pglD)
CSF: CSUB8523_1539(pglD)
CGRA: CGRAC_1487(pglD)
CURE: CUREO_1371(pglD)
CHYO: CHH_0380(pglD)
CHV: CHELV3228_0557(pglD)
CSPF: CSF_0890(pglD)
CPIN: CPIN18020_0865(pglD)
CCUN: CCUN_1174(pglD)
CLX: CLAN_0357(pglD)
CAVI: CAV_0413(pglD)
EUC: EC1_12030
 » show all
Taxonomy
Reference
1  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry 45:13659-69 (2006)
DOI:10.1021/bi061456h
  Sequence
[cje:Cj1123c]
Reference
2  [PMID:18198901]
  Authors
Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM
  Title
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter  jejuni.
  Journal
Biochemistry 47:1827-36 (2008)
DOI:10.1021/bi702032r
  Sequence
[cje:Cj1123c]
Reference
3  [PMID:21542610]
  Authors
Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B
  Title
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.
  Journal
Biochemistry 50:4936-48 (2011)
DOI:10.1021/bi2003372
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.203
IUBMB Enzyme Nomenclature: 2.3.1.203
ExPASy - ENZYME nomenclature database: 2.3.1.203
BRENDA, the Enzyme Database: 2.3.1.203

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