KEGG   ENZYME: 2.3.1.206Help
Entry
EC 2.3.1.206                Enzyme                                 

Name
3,5,7-trioxododecanoyl-CoA synthase;
TKS (ambiguous);
olivetol synthase (incorrect)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming)
Reaction(IUBMB)
3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 [RN:R10171]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
hexanoyl-CoA [CPD:C05270]
Product
CoA [CPD:C00010];
3,5,7-trioxododecanoyl-CoA [CPD:C20413];
CO2 [CPD:C00011]
Comment
A polyketide synthase catalysing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalysed by EC 4.4.1.26, olivetolic acid cyclase.
History
EC 2.3.1.206 created 2012
Pathway
ec00999  Biosynthesis of secondary metabolites - unclassified
Orthology
K20503  3,5,7-trioxododecanoyl-CoA synthase
Reference
1  [PMID:19454282]
  Authors
Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S
  Title
Characterization of olivetol synthase, a polyketide synthase putatively involved  in cannabinoid biosynthetic pathway.
  Journal
FEBS Lett 583:2061-6 (2009)
DOI:10.1016/j.febslet.2009.05.024
  Sequence
Reference
2  [PMID:22802619]
  Authors
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE
  Title
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
  Journal
Proc Natl Acad Sci U S A 109:12811-6 (2012)
DOI:10.1073/pnas.1200330109
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.206
IUBMB Enzyme Nomenclature: 2.3.1.206
ExPASy - ENZYME nomenclature database: 2.3.1.206
BRENDA, the Enzyme Database: 2.3.1.206

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