KEGG   ENZYME: 2.3.1.207Help
Entry
EC 2.3.1.207                Enzyme                                 

Name
beta-ketodecanoyl-[acyl-carrier-protein] synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
octanoyl-CoA:malonyl-[acyl-carrier protein] C-heptanoylltransferase (decarboxylating, CoA-forming)
Reaction(IUBMB)
octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 [RN:R10172]
Reaction(KEGG)
Substrate
octanoyl-CoA [CPD:C01944];
malonyl-[acyl-carrier protein] [CPD:C01209]
Product
3-oxodecanoyl-[acyl-carrier protein] [CPD:C05753];
CoA [CPD:C00010];
CO2 [CPD:C00011]
Comment
This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for beta-oxidation degradation intermediates into de novo fatty acid biosynthesis.
History
EC 2.3.1.207 created 2012
Orthology
K16872  beta-ketodecanoyl-[acyl-carrier-protein] synthase
Genes
PSHI: SAMEA2665130_0711(fabH_1)
PAE: PA3286
PAEV: N297_3403
PAEI: N296_3403
PAU: PA14_21540(fabH-2)
PAP: PSPA7_1833
PAG: PLES_17791
PAF: PAM18_1682
PNC: NCGM2_4414(fabH-2)
PAEB: NCGM1900_2994(fabH-2)
PAEP: PA1S_08920
PAEM: U769_08425
PAEL: T223_08920
PAEG: AI22_24960
PAEC: M802_3401
PAEO: M801_3268
PMY: Pmen_1545
PMK: MDS_1612
PPSE: BN5_2858(fabH)
PCQ: PcP3B5_15030(fabH)
PPU: PP_4545
PPF: Pput_1345
PPT: PPS_3891
PPI: YSA_07809
PPX: T1E_0854
PPUH: B479_19325
PPUT: L483_24815
PPUN: PP4_12760
PPUD: DW66_4329
PMON: X969_18985
PMOT: X970_18620
PSB: Psyr_3830
PSYR: N018_06355
PFL: PFL_1532(fabH_1)
PPRC: PFLCHA0_c15710(fabH1)
PPRO: PPC_1586
PFS: PFLU_4539
PFC: PflA506_3851(fabH_2)
PFW: PF1751_v1c40400(fabH)
PFB: VO64_4996
PMAN: OU5_1920
PEN: PSEEN3967
PSA: PST_2842
PSTT: CH92_15640
PPUU: PputUW4_03987(fabH2)
PKC: PKB_1532
PSES: PSCI_3097
PSEM: TO66_07595
PSOS: POS17_1538
PANR: A7J50_4221
PSET: THL1_4087
PSIL: PMA3_22160
PAR: Psyc_1052
PALI: A3K91_1404
PSYC: DABAL43B_1409(fabH)
PSYA: AOT82_465
ACB: A1S_1208
ABM: ABSDF1494
ABY: ABAYE2562
ABN: AB57_1343
ABX: ABK1_1640
ABH: M3Q_1564
ABAD: ABD1_12170(fabH)
ABAZ: P795_11450
ABAU: IX87_04610
ABAA: IX88_08110
ACC: BDGL_000459(fabH)
ACI: ACIAD2101
MCT: MCR_0863(fabH)
MCS: DR90_1016
MCAT: MC25239_00867(fabH)
SON: SO_2901
SDN: Sden_2519
SFR: Sfri_2467
SAZ: Sama_1510
CPS: CPS_1068
PAT: Patl_3297
MAQ: Maqu_1591
MHC: MARHY1693
MAD: HP15_1862
MBS: MRBBS_2153(fabH)
AMAL: I607_14530
AMAE: I876_14825
AMAO: I634_14770
AMAD: I636_14645
AMAI: I635_15200
AMAG: I533_14350
AAUS: EP12_15130
ASP: AOR13_405
GNI: GNIT_2715(fabH)
GPS: C427_1538
MVS: MVIS_1220
SAGA: M5M_09995
MICC: AUP74_01244(fabH)
HCH: HCH_02649
CSA: Csal_1470
HEL: HELO_2120
HAM: HALO1885
HCO: LOKO_02597(fabH)
ABO: ABO_1520(fabB)
ADI: B5T_02481(fabB2)
APAC: S7S_07835
AXE: P40_12045
TOL: TOL_2727
OME: OLMES_3328(fabH)
AHA: AHA_3035
ASA: ASA_3056
AVR: B565_2885
AMED: B224_3784
ACAV: VI35_14685
SALN: SALB1_3236
GPB: HDN1F_33740(fabH)
CVI: CV_1096
PSE: NH8B_3422(fabH)
RSO: RSp0194
RSN: RSPO_m00190(fabH)
RSE: F504_3635
RPI: Rpic_4712
PLG: NCTC10937_04148(fabH1)
RFR: Rfer_2770
RTA: Rta_04890
JAG: GJA_5154
RGE: RGE_18370
CCRO: CMC5_066050(fabH)
HOH: Hoch_0130
MLO: mll1602
MES: Meso_2031
AMIH: CO731_02758(fabH_1) CO731_04799(fabH_4)
PLA: Plav_0744
RPA: RPA1298
RPB: RPB_4123
RPC: RPC_2800
RPD: RPD_3969
RPE: RPE_0742
RPT: Rpal_1489
HDN: Hden_3439
RVA: Rvan_1310
CCR: CC_1442
CAK: Caul_2904
CSE: Cseg_1924
PZU: PHZ_c1369
SIL: SPO0918(fabH-1)
RCP: RCAP_rcc01145(fabH1)
JAN: Jann_3320
RDE: RD1_3492(fabH)
PGD: Gal_00929
OTM: OSB_23750(fabH_2)
CID: P73_0926
HNE: HNE_0857
HBA: Hbal_3184
SAL: Sala_3145
SPHP: LH20_01175
SMAZ: LH19_00555
SPHU: SPPYR_3162
BLAS: BSY18_2210
ELI: ELI_03745
ADO: A6F68_02576(fabH_2)
MAI: MICA_879
MAN: A11S_795
AYM: YM304_41580(fabH)
 » show all
Taxonomy
Reference
1  [PMID:22753057]
  Authors
Yuan Y, Leeds JA, Meredith TC
  Title
Pseudomonas aeruginosa directly shunts beta-oxidation degradation intermediates into de novo fatty acid biosynthesis.
  Journal
J Bacteriol 194:5185-96 (2012)
DOI:10.1128/JB.00860-12
  Sequence
[pae:PA3286]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.207
IUBMB Enzyme Nomenclature: 2.3.1.207
ExPASy - ENZYME nomenclature database: 2.3.1.207
BRENDA, the Enzyme Database: 2.3.1.207

DBGET integrated database retrieval system