KEGG   ENZYME: 2.3.1.208Help
Entry
EC 2.3.1.208                Enzyme                                 

Name
4-hydroxycoumarin synthase;
BIS2;
BIS3
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase
Reaction(IUBMB)
malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2 [RN:R10173]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
2-hydroxybenzoyl-CoA [CPD:C20394]
Product
CoA [CPD:C00010];
4-hydroxycoumarin [CPD:C20414];
CO2 [CPD:C00011]
Comment
The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1].
History
EC 2.3.1.208 created 2012
Orthology
K21384  3,5-dihydroxybiphenyl/4-hydroxycoumarin synthase
Genes
FVE: 101312413
PPER: 109948444 18780920 18781256
PMUM: 103326884 103326885
PAVI: 110755238
MDM: 103407511 103418590 103424764 103455021 103456249 103456250
PXB: 103945211 103945212 103946755 103946756 103946757 103946758 103946760 103946761
Taxonomy
Reference
1  [PMID:19757094]
  Authors
Liu B, Raeth T, Beuerle T, Beerhues L
  Title
A novel 4-hydroxycoumarin biosynthetic pathway.
  Journal
Plant Mol Biol 72:17-25 (2010)
DOI:10.1007/s11103-009-9548-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.208
IUBMB Enzyme Nomenclature: 2.3.1.208
ExPASy - ENZYME nomenclature database: 2.3.1.208
BRENDA, the Enzyme Database: 2.3.1.208

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