KEGG   ENZYME: 2.3.1.21Help
Entry
EC 2.3.1.21                 Enzyme                                 

Name
carnitine O-palmitoyltransferase;
CPT;
CPTo;
outer malonyl-CoA inhibitable carnitine palmitoyltransferase;
CPTi;
CPT I (outer membrane carnitine palmitoyl transferase);
carnitine palmitoyltransferase I;
carnitine palmitoyltransferase II;
CPT-A;
CPT-B;
acylcarnitine transferase;
carnitine palmitoyltransferase;
carnitine palmitoyltransferase-A;
L-carnitine palmitoyltransferase;
palmitoylcarnitine transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
palmitoyl-CoA:L-carnitine O-palmitoyltransferase
Reaction(IUBMB)
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine [RN:R01923]
Reaction(KEGG)
Substrate
palmitoyl-CoA [CPD:C00154];
L-carnitine [CPD:C00318]
Product
CoA [CPD:C00010];
L-palmitoylcarnitine [CPD:C02990]
Comment
Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.
History
EC 2.3.1.21 created 1972
Pathway
ec00071  Fatty acid degradation
Orthology
K08765  carnitine O-palmitoyltransferase 1, liver isoform
K08766  carnitine O-palmitoyltransferase 2
K19523  carnitine O-palmitoyltransferase 1, muscle isoform
K19524  carnitine O-palmitoyltransferase 1, brain isoform
Genes
HSA: 126129(CPT1C) 1374(CPT1A) 1375(CPT1B) 1376(CPT2)
PTR: 451382(CPT1A) 470253(CPT1B) 737945(CPT2) 748258(CPT1C)
PPS: 100969017(CPT1A) 100977928(CPT1B) 100978250(CPT1C) 100983874(CPT2)
GGO: 101128037(CPT1A) 101141306(CPT1B) 101147238(CPT1C) 101147523(CPT2) 109028728 109028908
PON: 100172407(CPT1C) 100442465(CPT2) 100444942(CPT1B) 100446735(CPT1A)
NLE: 100586407(CPT1C) 100588984(CPT1A) 100591075(CPT1B) 100594710(CPT2)
MCC: 709837(CPT1A) 714150(CPT2) 719429(CPT1C) 720697(CPT1B)
MCF: 101866032(CPT1B) 101926183(CPT1A) 102134440(CPT1C) 102137160(CPT2)
CSAB: 103223575(CPT1B) 103224794(CPT2) 103235051(CPT1C) 103248480(CPT1A)
RRO: 104655519(CPT1B) 104658386(CPT1A) 104667209(CPT1C) 104669303(CPT2)
RBB: 108531224(CPT2) 108535821(CPT1C) 108538087(CPT1A) 108539398 108545019
CJC: 100391686(CPT1C) 100403111(CPT1A) 100403864(CPT1B) 100414414(CPT2)
SBQ: 101033529(CPT2) 101043828(CPT1C) 101044692(CPT1A) 101045068(CPT1B)
MMU: 12894(Cpt1a) 12895(Cpt1b) 12896(Cpt2) 78070(Cpt1c)
RNO: 25413(Cpt2) 25756(Cpt1b) 25757(Cpt1a) 308579(Cpt1c)
CGE: 100762166(Cpt1a) 100766757(Cpt2) 100767138(Cpt1c) 100770034(Cpt1b)
NGI: 103730274(Cpt2) 103735491(Cpt1b) 103743677(Cpt1c) 103744525(Cpt1a)
HGL: 101709766(Cpt2) 101716055(Cpt1a) 101719936(Cpt1c) 101724285(Cpt1b)
CCAN: 109682869(Cpt2) 109683908(Cpt1c) 109697469(Cpt1b) 109700002(Cpt1a)
TUP: 102481324(CPT1B) 102485726(CPT2) 102486942(CPT1C) 102493851(CPT1A)
CFA: 100856778(CPT1C) 403583(CPT1A) 481184(CPT1B) 489585(CPT2)
AML: 100465139(CPT2) 100470509(CPT1C) 100476203(CPT1B) 100482719(CPT1A)
UMR: 103657260(CPT1C) 103670701(CPT2) 103673998(CPT1B) 103679534(CPT1A)
ORO: 101363059(CPT1C) 101367746(CPT2) 101373025(CPT1A) 101378588(CPT1B)
FCA: 101083187(CPT1B) 101093287(CPT2) 101095144(CPT1C) 101096105(CPT1A)
PTG: 102948684(CPT2) 102952682(CPT1B) 102960681(CPT1A) 102969205(CPT1C)
AJU: 106971087(CPT1A) 106975005(CPT2) 106983111(CPT1C) 106987645(CPT1B)
BTA: 504502(CPT2) 506812(CPT1A) 509459(CPT1B) 513710(CPT1C)
BOM: 102265568(CPT1A) 102269192(CPT1B) 102281690(CPT2) 102287746(CPT1C)
BIU: 109554147(CPT1A) 109556280(CPT2) 109572985(CPT1C)
PHD: 102321116(CPT2) 102328573(CPT1A) 102336252(CPT1C) 102343440(CPT1B)
CHX: 102173497(CPT1C) 102180988(CPT2) 102187210(CPT1B) 102187923(CPT1A)
OAS: 101113171(CPT1C) 101118317(CPT2) 443193(CPT1B) 443434(CPT1A)
SSC: 100519258(CPT1C) 100519491(CPT2) 399527(CPT1A) 399528(CPT1B)
CFR: 102505825(CPT1C) 102517968(CPT1A) 102519937(CPT2) 102524549(CPT1B)
CDK: 105090776(CPT2) 105100195(CPT1C) 105104399(CPT1A) 105106153(CPT1B)
BACU: 103003703(CPT1C) 103007290(CPT2) 103011201(CPT1A) 103015428(CPT1B)
LVE: 103068754(CPT1A) 103073152(CPT1C) 103073664(CPT1B) 103082924(CPT2)
OOR: 101269413(CPT1B) 101271337(CPT1C) 101271948(CPT1A) 101278411(CPT2)
ECB: 100009716(CPT1A) 100055438(CPT1B) 100056027(CPT1C) 100061061(CPT2)
EPZ: 103544662(CPT1C) 103551279(CPT1A) 103558611(CPT2) 103564749(CPT1B)
EAI: 106824163(CPT1C) 106833186(CPT2) 106844268(CPT1A) 106846020(CPT1B)
MYB: 102242927(CPT1C) 102243793(CPT2) 102252400(CPT1B) 102261269(CPT1A)
MYD: 102759504(CPT1A) 102764960(CPT1B) 102766661(CPT2) 102770000(CPT1C)
HAI: 109389301(CPT1A) 109391119(CPT1C) 109395421(CPT2) 109396636(CPT1B)
RSS: 109438164(CPT1B) 109452576(CPT1C) 109453246(CPT2) 109460361(CPT1A)
PALE: 102878033(CPT1C) 102879520(CPT1B) 102886073(CPT1A) 102886099(CPT2)
LAV: 100665512(CPT2) 100665922(CPT1A) 100667001(CPT1C) 100677247(CPT1B)
MDO: 100012188(CPT1B) 100012915(CPT1A) 100017404(CPT2)
SHR: 100921521(CPT2) 100921785 100927393 100930017(CPT1B) 100931262(CPT1A) 105749969(CPT1C)
GGA: 423118(CPT1A) 424649(CPT2)
MGP: 100540756(CPT2) 100549362(CPT1A)
CJO: 107314442(CPT1A) 107317653(CPT2)
APLA: 101795062(CPT1B) 101799612(CPT1A) 101804289(CPT2)
ACYG: 106033001(CPT2) 106044877(CPT1A) 106048146(CPT1B)
TGU: 100222209(CPT2) 100226785(CPT1A)
GFR: 102042619(CPT1A) 102043131(CPT2)
FAB: 101819946(CPT1A) 101821336(CPT2)
PHI: 102103127(CPT1A) 102105403 102106295(CPT2)
PMAJ: 107199664 107205732(CPT1A) 107208252(CPT2)
CCAE: 111930121(CPT1A) 111944660(CPT2)
CCW: 104693295(CPT1A) 104695521(CPT2)
FPG: 101915684(CPT1A) 101916323(CPT1B) 101916680(CPT2)
FCH: 102046436(CPT2) 102056621(CPT1A) 102058618(CPT1B)
CLV: 102085732(CPT2) 102089943(CPT1A) 102094115(CPT1B)
EGZ: 104131502(CPT2) 104132611(CPT1A)
AAM: 106482194(CPT1A) 106491073(CPT2)
ASN: 102369422(CPT1B) 102370264(CPT1C) 102377631(CPT1A) 102378221(CPT2) 102381122(SPATA9)
AMJ: 102569677(CPT2) 102570199(CPT1C) 102571274(CPT1B) 102572778(CPT1A) 106738940 109282261
PSS: 102449072(CPT1A) 102453263(CPT2) 102460096
CMY: 102932067(CPT2) 102941741(CPT1B) 102943921(CPT1A) 102948102
CPIC: 101939045 101939314(CPT2) 101939477(CPT1C) 101941820(CPT1A) 101948620(CPT1B)
ACS: 100551969(cpt1b) 100554332(cpt1a) 100559925(cpt2) 100560465(cpt1c) 100564964
PVT: 110074166(CPT1A) 110078753 110079173(CPT1C) 110082263(CPT2) 110084411(CPT1B)
PBI: 103049945(CPT1B) 103050777(CPT2) 103057982(CPT1A) 103059017 103062048(CPT1C)
GJA: 107111801(CPT1A) 107119323(CPT1B) 107120350(CPT1C) 107120570(CPT2) 107124700
XLA: 108713843 108714327(cpt2.L) 108715191 379393(cpt1a.L) 379893(cpt2.S) 495682(cpt1b.L)
XTR: 100135089(cpt1a) 100490391 394801(cpt2) 780223(cpt1b)
NPR: 108783819(CPT2) 108792107 108793465(CPT1B) 108795865(CPT1A)
DRE: 100005717(cpt2) 100333227 558088(cpt1aa) 560000(cpt1ab)
IPU: 108259197(CPT1A) 108264444(cpt1b) 108265663(cpt2) 108269775 108275128(cpt1a)
LCM: 102352070 102353513(CPT2) 102357148(CPT1C) 102359458(CPT1A)
DME: Dmel_CG12891(whd) Dmel_CG2107(CPT2)
DSI: Dsimw501_GD13716(Dsim_GD13716) Dsimw501_GD25979(Dsim_GD25979)
CEL: CELE_R07H5.2(cpt-2) CELE_Y46G5A.17(cpt-1)
CBR: CBG06027(Cbr-cpt-2) CBG07886(Cbr-cpt-1)
HMG: 100206022(cpt1a) 100212546(cpt1a) 100214547(cpt2)
MMI: MMAR_0691
 » show all
Taxonomy
Reference
1
  Authors
Derrick, J.P., Tubbs, P.K. and Ramsay, R.R.
  Title
Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria.
  Journal
Biochem Soc Trans 14:698 (1986)
Reference
2  [PMID:3342008]
  Authors
Healy MJ, Kerner J, Bieber LL.
  Title
Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?
  Journal
Biochem J 249:231-7 (1988)
Reference
3  [PMID:6630173]
  Authors
Miyazawa S, Ozasa H, Osumi T, Hashimoto T.
  Title
Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver.
  Journal
J Biochem (Tokyo) 94:529-42 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.21
IUBMB Enzyme Nomenclature: 2.3.1.21
ExPASy - ENZYME nomenclature database: 2.3.1.21
BRENDA, the Enzyme Database: 2.3.1.21
CAS: 9068-41-1

DBGET integrated database retrieval system