KEGG   ENZYME: 2.3.1.217Help
Entry
EC 2.3.1.217                Enzyme                                 

Name
curcumin synthase;
CURS;
CURS1 (gene name);
CURS2 (gene name);
CURS3 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
feruloyl-CoA:feruloylacetyl-CoA feruloyltransferase (curcumin-forming)
Reaction(IUBMB)
feruloyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + curcumin + CO2 [RN:R08810]
Reaction(KEGG)
R08810;
(other) R08808
Show
Substrate
feruloyl-CoA [CPD:C00406];
feruloylacetyl-CoA [CPD:C17741];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
curcumin [CPD:C10443];
CO2 [CPD:C00011]
Comment
A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well [2] (see EC 2.3.1.219, demethoxycurcumin synthase).
History
EC 2.3.1.217 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13234  curcumin synthase
K17211  curcumin/demethoxycurcumin synthase
Genes
MUS: 103976634
Taxonomy
Reference
1  [PMID:19258320]
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S.
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
DOI:10.1074/jbc.M900070200
  Sequence
Reference
2  [PMID:19622354]
  Authors
Katsuyama Y, Kita T, Horinouchi S
  Title
Identification and characterization of multiple curcumin synthases from the herb  Curcuma longa.
  Journal
FEBS Lett 583:2799-803 (2009)
DOI:10.1016/j.febslet.2009.07.029
  Sequence
Reference
3  [PMID:21148316]
  Authors
Katsuyama Y, Miyazono K, Tanokura M, Ohnishi Y, Horinouchi S
  Title
Structural and biochemical elucidation of mechanism for decarboxylative condensation of beta-keto acid by curcumin synthase.
  Journal
J Biol Chem 286:6659-68 (2011)
DOI:10.1074/jbc.M110.196279
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.217
IUBMB Enzyme Nomenclature: 2.3.1.217
ExPASy - ENZYME nomenclature database: 2.3.1.217
BRENDA, the Enzyme Database: 2.3.1.217

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