KEGG   ENZYME: 2.3.1.43Help
Entry
EC 2.3.1.43                 Enzyme                                 

Name
phosphatidylcholine---sterol O-acyltransferase;
lecithin---cholesterol acyltransferase;
phospholipid---cholesterol acyltransferase;
LCAT (lecithin-cholesterol acyltransferase);
lecithin:cholesterol acyltransferase;
lysolecithin acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
phosphatidylcholine:sterol O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester [RN:R02114]
Reaction(KEGG)
Substrate
phosphatidylcholine [CPD:C00157];
sterol [CPD:C00370]
Product
1-acylglycerophosphocholine [CPD:C04230];
sterol ester [CPD:C01958]
Comment
Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.
History
EC 2.3.1.43 created 1972, modified 1976
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K00650  lecithin-cholesterol acyltransferase
Genes
HSA: 3931(LCAT)
PTR: 743056(LCAT)
PPS: 100976085(LCAT)
GGO: 109023671(LCAT)
PON: 103892697(LCAT)
NLE: 100590850(LCAT)
MCC: 701872(LCAT)
MCF: 102126888(LCAT)
CSAB: 103233251(LCAT)
RRO: 104655608(LCAT)
RBB: 108515381(LCAT)
CJC: 108587667(LCAT)
SBQ: 101036892(LCAT)
MMU: 16816(Lcat)
RNO: 24530(Lcat)
CGE: 100751451(Lcat)
NGI: 103738876(Lcat)
HGL: 101700977(Lcat)
CCAN: 109691255(Lcat)
OCU: 100008978(LCAT)
TUP: 102475836(LCAT)
CFA: 479680(LCAT)
AML: 100469078(LCAT)
UMR: 103673641(LCAT)
ORO: 101381788(LCAT)
FCA: 101083225(LCAT)
PTG: 102970547(LCAT)
AJU: 106971916(LCAT)
BTA: 510960(LCAT)
BOM: 102264672(LCAT)
BIU: 109572303(LCAT)
PHD: 102320207(LCAT)
CHX: 102189984(LCAT)
OAS: 100302343(LCAT)
SSC: 100303723(LCAT)
CFR: 102521480(LCAT)
CDK: 105088423(LCAT)
BACU: 103016695(LCAT)
LVE: 103082679(LCAT)
OOR: 101284170(LCAT)
ECB: 100053753(LCAT)
EPZ: 103549703(LCAT)
EAI: 106822471(LCAT)
MYB: 102263247(LCAT)
MYD: 102767701(LCAT)
HAI: 109389599(LCAT)
RSS: 109460701(LCAT)
PALE: 102882548(LCAT)
LAV: 100663727(LCAT)
TMU: 101354314
MDO: 100021772(LCAT)
SHR: 100916426(LCAT)
OAA: 100073500(LCAT)
GGA: 396136(LCAT)
MGP: 100539055(LCAT)
CJO: 107319111(LCAT)
APLA: 101801832(LCAT)
ACYG: 106033314(LCAT)
TGU: 100226110(LCAT)
GFR: 102045237(LCAT)
FAB: 101808995(LCAT)
PHI: 102109484(LCAT)
PMAJ: 107209690(LCAT)
CCW: 104691778(LCAT)
FPG: 101919855(LCAT)
FCH: 102054279(LCAT)
CLV: 102095422(LCAT)
EGZ: 104130251(LCAT)
AAM: 106484516(LCAT)
ASN: 102378544(LCAT)
AMJ: 102562663(LCAT)
PSS: 102457801
CMY: 102935489
CPIC: 101933197(LCAT)
ACS: 100564490(lcat)
PVT: 110081332(LCAT)
PBI: 103048717(LCAT)
GJA: 107108015(LCAT)
XLA: 447501(lcat.L)
XTR: 448241(lcat)
DRE: 793137(lcat)
SRX: 107714079
SGH: 107572072(lcat)
CCAR: 109050579(lcat)
IPU: 100528492(lcat)
AMEX: 103041308(lcat)
TRU: 101068878(lcat)
LCO: 104935935(lcat)
MZE: 101464448(lcat)
OLA: 101172491(lcat)
XMA: 102230865
PRET: 103466226(lcat)
NFU: 107389202(lcat)
KMR: 108246908
LCF: 108902284(lcat)
SDU: 111222526
HCQ: 109530510(lcat)
BPEC: 110169665(lcat)
MALB: 109962590(lcat)
OTW: 112218440(lcat)
ELS: 105018521(lcat)
SFM: 108926635(lcat)
LCM: 102355092(LCAT)
CMK: 103187891(lcat)
EHI: EHI_031360(63.t00024) EHI_136400(33.t00023)
 » show all
Taxonomy
Reference
1
  Authors
Bartlett, K., Keat, M.J. and Mercer, E.I.
  Title
Biosynthesis of sterol esters in Phycomyces blakesleeanus.
  Journal
Phytochemistry 13:1107-1113 (1974)
Reference
2  [PMID:7061477]
  Authors
Buckley JT, Halasa LN, MacIntyre S.
  Title
Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.
  Journal
J Biol Chem 257:3320-5 (1982)
Reference
3  [PMID:4868699]
  Authors
Glomset JA.
  Title
The plasma lecithins:cholesterol acyltransferase reaction.
  Journal
J Lipid Res 9:155-67 (1968)
Reference
4  [PMID:4877146]
  Authors
Vahouny GV, Treadwell CR.
  Title
Enzymatic synthesis and hydrolysis of cholesterol esters.
  Journal
Methods Biochem Anal 16:219-72 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.43
IUBMB Enzyme Nomenclature: 2.3.1.43
ExPASy - ENZYME nomenclature database: 2.3.1.43
BRENDA, the Enzyme Database: 2.3.1.43
CAS: 9031-14-5

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