KEGG   ENZYME: 2.3.1.44Help
Entry
EC 2.3.1.44                 Enzyme                                 

Name
N-acetylneuraminate 4-O-acetyltransferase;
sialate O-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate [RN:R01806]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
N-acetylneuraminate [CPD:C00270]
Product
CoA [CPD:C00010];
N-acetyl-4-O-acetylneuraminate [CPD:C04015]
Comment
Both free and glycosidically bound N-acetyl- and N-glycolyl- neuraminates can act as O-acetyl acceptors.
History
EC 2.3.1.44 created 1972
Reference
1  [PMID:5446640]
  Authors
Schauer R.
  Title
[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse]
  Journal
Hoppe Seylers Z Physiol Chem 351:595-602 (1970)
Reference
2  [PMID:5425947]
  Authors
Schauer R.
  Title
[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase]
  Journal
Hoppe Seylers Z Physiol Chem 351:749-58 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.44
IUBMB Enzyme Nomenclature: 2.3.1.44
ExPASy - ENZYME nomenclature database: 2.3.1.44
BRENDA, the Enzyme Database: 2.3.1.44
CAS: 51004-25-2

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