KEGG   ENZYME: 2.3.1.5Help
Entry
EC 2.3.1.5                  Enzyme                                 

Name
arylamine N-acetyltransferase;
arylamine acetylase;
beta-naphthylamine N-acetyltransferase;
4-aminobiphenyl N-acetyltransferase;
acetyl CoA-arylamine N-acetyltransferase;
2-naphthylamine N-acetyltransferase;
arylamine acetyltransferase;
indoleamine N-acetyltransferase;
N-acetyltransferase (ambiguous);
p-aminosalicylate N-acetyltransferase;
serotonin acetyltransferase;
serotonin N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:arylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine [RN:R02387]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
arylamine [CPD:C00292]
Product
CoA [CPD:C00010];
N-acetylarylamine [CPD:C07565]
Comment
Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.
History
EC 2.3.1.5 created 1961
Pathway
ec00232  Caffeine metabolism
ec00633  Nitrotoluene degradation
ec00983  Drug metabolism - other enzymes
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00622  arylamine N-acetyltransferase
Genes
HSA: 10(NAT2) 9(NAT1)
PTR: 464023(NAT1) 464024(NAT2)
PPS: 100990661(NAT2) 100991667(NAT1)
GGO: 101150362(NAT1) 101152545(NAT2)
PON: 100435042(NAT1) 100437283(NAT2)
NLE: 100580331(NAT1) 100580987(NAT2)
MCC: 704019(NAT1) 704357(NAT2)
MCF: 102119914(NAT1) 102121561(NAT2)
CSAB: 103215401(NAT1) 103215403(NAT2)
RRO: 104655225(NAT1) 104655226(NAT2)
CJC: 100397995(NAT1)
SBQ: 101045716(NAT1) 101047286(NAT2)
MMU: 17960(Nat1) 17961(Nat2) 17962(Nat3)
RNO: 116631(Nat1) 116632(Nat2) 290681(Nat3)
CGE: 100689282(Nat2) 100755335
OCU: 100008974(NAT2) 100328959(NAT1)
TUP: 102486411(NAT1) 102487228
AML: 100480317
UMR: 103677031
ORO: 101367643
FCA: 101095575
PTG: 102955781(NAT1)
AJU: 106976139
BTA: 512603(NAT1)
BOM: 102275700(NAT1)
BIU: 109553540
PHD: 102324364
CHX: 102169935(NAT1)
OAS: 101120889
SSC: 100511905
CFR: 102510309(NAT1)
CDK: 105086440
LVE: 103082317
OOR: 101280132
ECB: 100049837
EPZ: 103540532
EAI: 106833608
RSS: 109452793
MDO: 100027666
SHR: 100919466
OAA: 100077007
GGA: 396283(PNAT10) 396537(NAT) 415809(PNAT3)
PVT: 110090098
GJA: 107109832 107109835(NAT1)
NPR: 108786559
DRE: 445194(zgc:101040) 449801(zgc:103601) 794381(si:dkey-78a14.4)
LCO: 104920774
NCC: 104955050
XMA: 102230777(nat1)
KMR: 108243328(nat1)
CSEM: 103383261
SDU: 111217696(nat1)
HCQ: 109514002
SASA: 106562381(ARY1) 106587573(ARY1)
OTW: 112249348
ELS: 105025705
CMK: 103172656(nat1)
MTU: Rv3566c(nat)
MTC: MT3671(nhoA)
MRA: MRA_3605(nat)
MTUR: CFBS_3782(nat)
MTO: MTCTRI2_3630(nat)
MTD: UDA_3566c(nat)
MTN: ERDMAN_3911(nat)
MTUC: J113_24975
MTUE: J114_19070
MTUH: I917_25040
MTUL: TBHG_04161
MTUT: HKBT1_3767(nat)
MTUU: HKBT2_3776(nat)
MTQ: HKBS1_3779(nat)
MBO: BQ2027_MB3596C(nat)
MBB: BCG_3630c(nat)
MBT: JTY_3631(nat)
MBM: BCGMEX_3628c(nat)
MAF: MAF_35780(nat)
MMIC: RN08_3943
MCE: MCAN_35771(nat)
MCQ: BN44_110058(nat)
MCV: BN43_90064(nat)
MCX: BN42_90063(nat)
MCZ: BN45_100065(nat)
MPA: MAP_0501(nhoA)
MAO: MAP4_3366
MAVI: RC58_16695
MAVU: RE97_16730
MAV: MAV_0595
MIT: OCO_05040
MIA: OCU_05080
MID: MIP_00946
MYO: OEM_05100
MIR: OCQ_05190
MUL: MUL_4131(nat)
MMC: Mmcs_0211
MKM: Mkms_0221
MJL: Mjls_0201
MMI: MMAR_5055(nat)
MMAE: MMARE11_48700(nat)
MMM: W7S_02460
MLI: MULP_05313(nat)
MHAD: B586_04480
MSG: MSMEI_0299(nat)
MVA: Mvan_0235
MGI: Mflv_0433
MJD: JDM601_0190(nat)
BLIN: BLSMQ_0631
PSEA: WY02_03235
PSEE: FRP1_09560
 » show all
Taxonomy
Reference
1  [PMID:12980945]
  Authors
CHOU TC, LIPMANN F.
  Title
Separation of acetyl transfer enzymes in pigeon liver extract.
  Journal
J Biol Chem 196:89-103 (1952)
Reference
2  [PMID:4748369]
  Authors
Paul RC, Ratledge C.
  Title
Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes.
  Journal
Biochim Biophys Acta 320:9-15 (1973)
DOI:10.1016/0304-4165(73)90160-8
Reference
3  [PMID:13084583]
  Authors
TABOR H, MEHLER AH, STADTMAN ER.
  Title
The enzymatic acetylation of amines.
  Journal
J Biol Chem 204:127-38 (1953)
Reference
4  [PMID:14005907]
  Authors
WEISSBACH H, REDFIELD BG, AXELROD J.
  Title
The exzymic acetylation of serotonin and other naturally occurring amines.
  Journal
Biochim Biophys Acta 54:190-2 (1961)
DOI:10.1016/0006-3002(61)90954-4
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.5
IUBMB Enzyme Nomenclature: 2.3.1.5
ExPASy - ENZYME nomenclature database: 2.3.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.5
BRENDA, the Enzyme Database: 2.3.1.5
CAS: 9027-33-2

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